Abstract: Quantification of the change in shape of the dicrotic notches of so-called distal pressure pulses acquired distal to a lesioned section of a lesioned blood vessel relative to the dicrotic notches of so-called proximal pressure pulses acquired proximal thereto enable determination of values of hemodynamic parameters. The envisaged hemodynamic parameters can include so-called Pulse Transmission Coefficients, non-hyperemic substitutes to the clinically accepted Fractional Flow Reserve and Coronary Flow Reserve indices, and a RC time constant indicative of the health of the vascular bed fed by a lesioned blood vessel.