Patents by Inventor Michael Orwat

Michael Orwat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20080090807
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: December 13, 2007
    Publication date: April 17, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch
  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20070135426
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: January 16, 2007
    Publication date: June 14, 2007
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch
  • Crystalline forms of a factor Xa inhibitor
    Publication number: 20060148846
    Abstract: The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl-ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6-tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.
    Type: Application
    Filed: December 14, 2005
    Publication date: July 6, 2006
    Inventors: Michael Orwat, Mary Malley, Roxana Schlam, Steven Fabian, Bing-Shiou Yang, Victor Rosso
  • Lactam-containing compounds and derivatives thereof as factor xa inhibitors
    Publication number: 20050267097
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: August 5, 2005
    Publication date: December 1, 2005
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch
  • Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
    Publication number: 20050261287
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 ??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: June 16, 2005
    Publication date: November 24, 2005
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch
  • Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
    Publication number: 20050171085
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: October 21, 2004
    Publication date: August 4, 2005
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch
  • Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
    Publication number: 20050124602
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: October 20, 2004
    Publication date: June 9, 2005
    Inventors: Donald Pinto, Mimi Quan, Michael Orwat, Yun-Long Li, Wei Han, Jennifer Qiao, Patrick Lam, Stephanie Koch