Abstract: Seed treatment devices and methods of treating seeds are provided. One example seed treatment device includes a mixing chamber in which seeds and a treatment formulation are mixed when received therein, a body having an inner surface defining at least part of the mixing chamber, a rotor having an inner surface defining at least a lower portion of the mixing chamber and configured to rotate to thereby cause the seeds in a lower portion of the mixing chamber to flow upwards along the inner surface of the rotor and the inner surface of the body, and one or more baffles. Each baffle includes a first concave surface configured to redirect the seeds and the treatment formulation when the rotor rotates in a first direction and a second concave surface configured to redirect the seeds and the treatment formulation when the rotor rotates in a second direction opposite the first direction.

Abstract: A process for producing a pharmaceutical formulation comprises the steps of: A) suspending a pharmaceutical active substance in an aqueous solution of a polymer; B) drying the mixture obtained in step A); wherein in step A) the pharmaceutical active substance is present in the form of particles having a d90 value in the particle size distribution of ?1 ?m and before step B) the pharmaceutical active substance is further contacted with an ionic surfactant.

Abstract: The present invention provides compositions comprising a substance of a particle size between 1 ?m and 100 ?m and a solubility in water between 0.0001 g/l and 10 g/l, at least 2 wt % of at least one cellulose based polymer, at least one anionic surfactant, at least one non-ionic surfactant, wherein the non-ionic surfactant is present in an amount of non-ionic surfactant to at least one cellulose based polymer in the range of between 10:1 and 1:10, wherein the ratio of the at least one cellulose based polymer and the at least one non-ionic surfactant together to the substance is between 2:1 to 1:2, and wherein the concentration of the substance of a particle size between 1 ?m and 100 ?m and a solubility in water between 0.0001 g/l and 10 g/l is in the range of 10.1 wt % to 15 wt %. The present invention also provides methods of manufacturing the compositions.

Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.

Abstract: A process for producing a pharmaceutical formulation comprises the steps of: A) suspending a pharmaceutical active substance in an aqueous solution of a polymer; B) drying the mixture obtained in step A); wherein in step A) the pharmaceutical active substance is present in the form of particles having a d90 value in the particle size distribution of ?1 ?m and before step B) the pharmaceutical active substance is further contacted with an ionic surfactant.

Abstract: A process for producing a pharmaceutical formulation comprising the steps of: A) providing particles of a polymer, wherein particles of a pharmaceutical active substance are additionally at least partially embedded in the particles of the polymer; B) heating the particles of the polymer to a predetermined temperature for a predetermined time and C) cooling the particles of the polymer after the predetermined time to a temperature of 18° C. to 24° C., wherein the polymer is at least partially soluble in water and the active substance is at least partially soluble in the polymer. The particulate pharmaceutical active substance is present in the form of particles having a d90 value in the particle size distribution of ?1 ?m. The predetermined temperature is within a range from 10 K below the glass transition temperature (determined by DSC in accordance with DIN EN ISO 11357-2 at a heating rate of 10 K/min) of the polymer to the melting temperature of the active substance.

Abstract: The present invention relates to encapsulated active compounds (actives/active ingredients/AI) produced by different methods with minimized/eliminated negative effects on the plant/enhanced biological compatibility while efficacy against pests is maintained.

Abstract: The invention relates to a method for monitoring a winding device (10), comprising the following steps: Displaying of a schematic illustration of functional units (20) of the winding device (10) on a display device (30), Detection of at least one operating parameter (40) of at least one functional unit (20) of the winding device (10), Displaying of the at least one detected operating parameter (40) on the display device (30) next to the schematic illustration of the corresponding functional unit (20).

Abstract: The invention relates to a method for monitoring a winding device (10), comprising the following steps: Displaying of a schematic illustration of functional units (20) of the winding device (10) on a display device (30), Detection of at least one operating parameter (40) of at least one functional unit (20) of the winding device (10), Displaying of the at least one detected operating parameter (40) on the display device (30) next to the schematic illustration of the corresponding functional unit (20).