Abstract: The invention provides a compound, for use as single compound or for use as a combination of at least two compounds, for use in the prevention and/or treatment of liver fibrosis and/or liver cirrhosis, e.g. as a pharmaceutically active compound for use in the prevention or treatment of liver fibrosis, which compound is an inhibitor of hyaluronan synthetase, or an inhibitor of integrin alpha-6.

Abstract: A nickel-based alloy which includes at least the following alloy elements in wt. %: cobalt (Co) 10.3-10.7, chromium (Cr) 9.8-10.2, tungsten (W) 9.3-9.7, aluminum (Al) 5.2-5.7, hafnium (Hf) 1.8-2.2, tantalum (Ta) 1.9-2.1, molybdenum (Mo) 0.4-0.6, the remainder being nickel and impurities.

Abstract: An apparatus for supporting a first ballistic shield and a second ballistic shield is disclosed. The apparatus has a structural frame, and a wheel assembly rotatably attached to a structural connector of a base assembly of the structural frame. The structural frame is configured to removably attach to the first ballistic shield. The structural frame is configured to removably attach to the second ballistic shield. The wheel assembly includes a plurality of axles spaced away from the structural connector and configured to rotate about the structural connector when the wheel assembly rotates.

Abstract: A method for modifying a polymer carrier material for use as a stationary phase in an analytical or preparative separating method, the method comprising the steps of: providing a polymer carrier material, which is at least partly formed of aromatic hydrocarbon compounds comprising at least two vinyl or allyl substituents; producing hydroxy groups on/in the polymer carrier material by a method comprising an oxidative treatment of the polymer carrier material and a subsequent reductive or hydrolytic treatment of the reaction product; reacting the product from the previous step with a polyfunctional compound. The invention also relates to a polymer carrier material for use as a stationary phase in an analytical or preparative separating method, in particular a chromatography method, produced according to a method according to the invention.

Abstract: The present invention relates to a metal-filled resin formulation, more particularly for a 3D printing method, on the basis of layer-by-layer photopolymerization for the manufacture of a component, wherein the resin formulation contains a photopolymerizable matrix component, a dense metal filler having a specific minimum volume fraction, and a photoinitiator. A component is additively manufactured by the layer-by-layer selective curing of the metal-filled resin formulation by means of irradiation with light. The invention in particular relates to the high-precision manufacture of radiation-absorbing components on the basis of lithographic additive processes such as SLA; because of the special choice of the formulation used, wall thicknesses down to less than 100 ?m are possible while still achieving good radiation hardness and good surface quality.

Abstract: The present invention relates to mRNA medicines for use in the therapy and prevention of liver diseases like liver fibrosis, liver cirrhosis, hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or liver cancer, and more particularly to mRNA medicines of this kind which can exhibit excellent therapeutic and preventive effects with respect to liver diseases individually developed or to complications resulting from diseases of these organs. In detail, the present invention relates to an mRNA suitable for treatment or prophylaxis of liver diseases. In particular, the present invention provides mRNAs encoding hepatocyte nuclear factor 4 alpha (HNF4A), human wild type and engineered variants thereof), or a fragment or a variant of any of these peptides or proteins. The present invention concerns said mRNA as well as compositions and kits comprising the mRNA.

Abstract: Power supply for a radar sensor that periodically transmits sequences with radar signals. Prior to the commencement of the transmission of radar signals, the radar sensor can provide a trigger signal at a power supply device, whereupon the power supply device temporarily adjusts the control behavior for the supply voltage of the radar sensor.

Abstract: A method for self-monitoring of a radar sensor, which carries out object detection of an object by way of a measurement process on the basis of a measurement signal and is monitored by way of self-monitoring carried out during the measurement process using a test signal superimposed on the measurement signal. The test signal is encoded by signal encoding such that it can be differentiated from the measurement signal. A radar sensor is also described.

Abstract: At least one example embodiment relates to a method of manufacturing an applicator. The method includes providing a shaft. The shaft has a first end and a second end opposite the first end. The method further includes providing a cap, providing a base portion, and forming an applicator. The forming the applicator includes connecting the cap to the first end of the shaft and connecting the base portion to the second end of the shaft.

Abstract: A metal composition, a method for additive manufacturing using such metal composition and the use of such metal composition is provided. The components of the metal composition are selected according to ranges and typically provide a more generic applicability in additive manufacturing.

Abstract: The disclosure is based on a medical imaging apparatus with a scanner, a patient support apparatus and a housing, which is arranged on the scanner and/or on the patient support apparatus, wherein the housing comprises at least one functional housing shell, wherein the at least one functional housing shell comprises at least one sensor element for detection of a hygiene status on the at least one functional housing shell, at least one output element, which is embodied for a visual display of the hygiene status, and at least one cleaning element for cleaning a surface of the at least one functional housing shell.

Abstract: A nickel-based alloy which includes at least the following alloy elements in wt. %: cobalt (Co) 10.3-10.7, chromium (Cr) 9.8-10.2, tungsten (W) 9.3-9.7, aluminum (Al) 5.2-5.7, hafnium (Hf) 1.8-2.2, tantalum (Ta) 1.9-2.1, molybdenum (Mo) 0.4-0.6, the remainder being nickel and impurities.

Abstract: A method and device for powder bed additive manufacturing of a component includes the selective irradiation of a layer made of a powder material with a first energy beam and a second energy beam, that is different from the first, wherein the second energy beam annularly surrounds the first energy beam, and the aselective heating of the layer, wherein a large part of the layer is heated to a temperature that is at least one quarter of the temperature that the layer is heated to as a result of the selective irradiation.

Abstract: A nickel-based superalloy without titanium and a corresponding powder. A process for producing a component, wherein the alloy or the powder is used, in particular for a process for additive manufacture, especially selective laser sintering or selective laser melting. A component having an alloy or produced from the powder or produced by the process.

Abstract: A method for modifying a polymer carrier material for use as a stationary phase in an analytical or preparative separating method, the method comprising the steps of: providing a polymer carrier material, which is at least partly formed of aromatic hydrocarbon compounds comprising at least two vinyl or allyl substituents; producing hydroxy groups on/in the polymer carrier material by a method comprising an oxidative treatment of the polymer carrier material and a subsequent reductive or hydrolytic treatment of the reaction product; reacting the product from the previous step with a polyfunctional compound. The invention also relates to a polymer carrier material for use as a stationary phase in an analytical or preparative separating method, in particular a chromatography method, produced according to a method according to the invention.

Abstract: The present invention relates to a compound for use as a medicament in the treatment or prevention of acute liver failure, which acute liver failure is induced by intoxication prior to or following administration of the compound. Accordingly, the invention relates to the compound for use in the treatment of an intoxication that without treatment is expected to result in acute liver failure or that without treatment is sufficient to induce acute liver failure. The invention also provides the compound for use in the treatment, and a corresponding method for the treatment of an intoxication sufficient to induce acute liver failure.

Abstract: A metal composition, a method for additive manufacturing using such metal composition and the use of such metal composition is provided. The components of the metal composition are selected according to ranges and typically provide a more generic applicability in additive manufacturing.

Abstract: A device for generating and/or processing a signal, and a method for ascertaining an adjustment of a device for processing or generating a signal. The method includes the steps: generating a transmission signal or a test signal with the aid of a signal device of a device; separating first signals, which come to the signal device from an interface device of the device, from second signals which come to the interface device from the signal device, the interface device being coupleable or coupled to a transmitting and/or receiving antenna; and outputting the first and the second signals separately from one another.

Abstract: A method for operating a radar sensor, having the steps: sending out a transmit signal; reception, by a receive unit, of the transmit signal reflected by at least one target object; evaluation of the receive signal; and regulation of a cutoff frequency of a high-pass filter as a function of the evaluated receive signal.

Abstract: A construction platform for the additive manufacturing of a component, in particular from a superalloy, wherein the construction platform has a surface region that is produced by an additive manufacturing method, wherein the additive manufacturing method is a beam melting or beam welding method. A construction platform is used as a substrate for the additive manufacturing of a component, in particular from a superalloy. A method includes the additive manufacturing of the construction platform, wherein a surface region of the construction platform is produced by a beam melting or beam welding method.