Abstract: A wheelchair accessible autonomous vehicle with improved interoperability between the ingress/egress doors, wheelchair access device, non-ingress/egress doors, and wheelchair securement system. Safety interlocks for those components may be automatically engaged and disengaged by vehicle computing systems during ingress and egress of a wheelchair based on input from one or more perception sensors associated with the vehicle, the ingress/egress doors, the non-ingress/egress doors, the wheelchair access device, the wheelchair securement system, and the wheelchair.

Abstract: The present invention relates to mRNA medicines for use in the therapy and prevention of liver diseases like liver fibrosis, liver cirrhosis, hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or liver cancer, and more particularly to mRNA medicines of this kind which can exhibit excellent therapeutic and preventive effects with respect to liver diseases individually developed or to complications resulting from diseases of these organs. In detail, the present invention relates to an mRNA suitable for treatment or prophylaxis of liver diseases. In particular, the present invention provides mRNAs encoding hepatocyte nuclear factor 4 alpha (HNF4A), human wild type and engineered variants thereof), or a fragment or a variant of any of these peptides or proteins. The present invention concerns said mRNA as well as compositions and kits comprising the mRNA.

Abstract: Provided herein are methods and compositions useful for identifying compounds that can inhibit SARS-CoV-2 infection or the effects thereof, especially in cardiomyocytes (CMs), which are highly infectible by SARS-CoV-2 corona viruses.

Abstract: The present invention discloses access devices and methods to create an access channel for introduction of one or more working devices into an anatomical region. The access channel is created using a visualization modality that is later removed before inserting one or more working devices through the access channel. This allows the methods and devices of the present invention to be used even in small sized natural or surgically created insertion tracts leading to the anatomical region. The access channel can be made of a device such as a sheath, a guidewire, and an elongate device comprising a lumen. Examples of visualization modalities are endoscopes and body insertable ultrasound imaging devices. The working devices can be used to perform a variety of diagnostic, therapeutic, or preventive procedures. Endometrial ablation devices and procedures have been used as an example to describe various aspects of the present invention.

Abstract: A cleaning method for cleaning a filling machine for filling at least to one side open packs with products is described and illustrated, wherein the filling machine has a transport device for transporting the at least to one side open packs through the filling machine. To ensure satisfactory cleaning results repeatably in a defined and/or shorter time, it is provided that a preceding plurality of at least to one side open packs is transported at least partially through the filling machine by a transport device and is filled with products, at least one nozzle for dispensing cleaning medium is transported at least partially through the filling machine by the transport device and cleaning medium is thereby dispensed for cleaning the filling machine, and after the filling machine has been cleaned, a subsequent plurality of at least to one side open packs is transported at least partially through the filling machine by the transport device and is thereby filled with products.

Abstract: An apparatus and process for heavy hydrocarbon (e.g., oils that include ten or more carbons, C10+ hydrocarbons, etc.) removal from a natural gas feed (e.g., a feed comprised of methane and impurities such as water and heavy hydrocarbons) can include utilization of one or more coalescing filters to provide adsorption of atomized (e.g., liquid) heavy hydrocarbons that can be present within the feed prior to the feed being fed to one or more adsorbers for adsorption of heavy hydrocarbon vapor via activated carbon beds within those adsorbers. Embodiments can be provided so that the size of downstream activated carbon bed adsorbers can be significantly reduced while also allowing such beds to have a longer life before needing to be replaced.

Abstract: Power supply for a radar sensor that periodically transmits sequences with radar signals. Prior to the commencement of the transmission of radar signals, the radar sensor can provide a trigger signal at a power supply device, whereupon the power supply device temporarily adjusts the control behavior for the supply voltage of the radar sensor.

Abstract: Described herein are methods and systems for producing a liquefied natural gas (LNG) product by cooling and liquefying a natural gas stream via indirect heat exchange with a gaseous refrigerant and then flashing and separating the liquefied natural gas stream to obtain the LNG product. In particular, the gaseous refrigerant may be a refrigerant circulating in a reverse Brayton cycle. The gaseous refrigerant is warmed in the shell side first, second and third coil-wound heat exchanger sections each having a tube side and a shell side, the shell side of the first coil-wound heat exchanger section being separated from and operating at a different pressure to the shell side of the second and third coil-wound heat exchanger sections.

Abstract: Described herein are methods and systems for removing natural gas liquids from a natural gas feed stream and for liquefying the natural gas feed stream so as to produce a liquefied natural gas (LNG) stream and a natural gas liquids (NGL) stream

Abstract: Described herein are methods and systems for producing a liquefied natural gas (LNG) product by cooling and liquefying a natural gas stream via indirect heat exchange with a gaseous refrigerant and then flashing and separating the liquefied natural gas stream to obtain the LNG product. In particular, the gaseous refrigerant may be a refrigerant circulating in a reverse Brayton cycle. The gaseous refrigerant is warmed in the shell side first, second and third coil-wound heat exchanger sections each having a tube side and a shell side, the shell side of the first coil-wound heat exchanger section being separated from and operating at a different pressure to the shell side of the second and third coil-wound heat exchanger sections.

Abstract: A method for self-monitoring of a radar sensor, which carries out object detection of an object by way of a measurement process on the basis of a measurement signal and is monitored by way of self-monitoring carried out during the measurement process using a test signal superimposed on the measurement signal. The test signal is encoded by signal encoding such that it can be differentiated from the measurement signal. A radar sensor is also described.

Abstract: At least one example embodiment relates to a method of manufacturing an applicator. The method includes providing a shaft. The shaft has a first end and a second end opposite the first end. The method further includes providing a cap, providing a base portion, and forming an applicator. The forming the applicator includes connecting the cap to the first end of the shaft and connecting the base portion to the second end of the shaft.

Abstract: A metal composition, a method for additive manufacturing using such metal composition and the use of such metal composition is provided. The components of the metal composition are selected according to ranges and typically provide a more generic applicability in additive manufacturing.

Abstract: The disclosure is based on a medical imaging apparatus with a scanner, a patient support apparatus and a housing, which is arranged on the scanner and/or on the patient support apparatus, wherein the housing comprises at least one functional housing shell, wherein the at least one functional housing shell comprises at least one sensor element for detection of a hygiene status on the at least one functional housing shell, at least one output element, which is embodied for a visual display of the hygiene status, and at least one cleaning element for cleaning a surface of the at least one functional housing shell.

Abstract: In some implementations, a device may receive image data identifying images of a space with racks and objects stored on the racks. The device may receive location data identifying location coordinates associated with the images. The device may process the image data and the location data to generate a merged point cloud identifying the racks and the objects in the space. The device may process the image data to generate mask data identifying at least a first mask for the racks and a second mask for the objects. The device may process the location data, the merged point cloud, and the mask data to generate a semantic point cloud identifying the racks and the objects in the space. The device may process the semantic point cloud, with a computer vision model, to calculate utilization metrics for the space.

Abstract: A nickel-based alloy which includes at least the following alloy elements in wt. %: cobalt (Co) 10.3-10.7, chromium (Cr) 9.8-10.2, tungsten (W) 9.3-9.7, aluminum (Al) 5.2-5.7, hafnium (Hf) 1.8-2.2, tantalum (Ta) 1.9-2.1, molybdenum (Mo) 0.4-0.6, the remainder being nickel and impurities.

Abstract: A method and device for powder bed additive manufacturing of a component includes the selective irradiation of a layer made of a powder material with a first energy beam and a second energy beam, that is different from the first, wherein the second energy beam annularly surrounds the first energy beam, and the aselective heating of the layer, wherein a large part of the layer is heated to a temperature that is at least one quarter of the temperature that the layer is heated to as a result of the selective irradiation.

Abstract: A system and method for integrated heavy hydrocarbon removal in a liquefaction system having a lean natural gas source. An economizer located between a main cryogenic heat exchanger and a reflux drum is provided to cool an overhead vapor stream against a partially condensed stream. In addition, pressure of the natural gas feed stream is maintained into a scrub column. A pressure drop is provided by a valve located between the economizer and the reflux drum on a partially condensed stream withdrawn from the cold end of the warm section of the main cryogenic heat exchanger.

Abstract: Described herein are coil wound heat exchangers (CWHEs), and methods of cooling and/or liquefying streams of fluid using said CWHEs, in which one or more tube layers of the tube bundle are provided with a non-uniform tube winding angle and tube pitch in order to facilitate the equalization of radial pressure imbalances on the shell side of the CWHE, thereby reducing radial maldistribution of fluid on the shell side and improving the heat transfer efficiency of the CWHE.

Abstract: A method and system for controlling the nitrogen concentration in an LNG product and fuel from flash gas within preferred ranges. A cooled LNG stream is separated into a nitrogen-enriched vapor stream, a fuel stream, and an LNG product stream using a plurality of phase separating devices, such as flash drum or rectifying column. A portion of the vapor stream is recycled to the rectifying column as reflux. A portion of a stream having a higher concentration of nitrogen is combined with the fuel stream to maintain the fuel stream within a desired nitrogen concentration range.