Patents by Inventor Michael P. Bevilacqua

Michael P. Bevilacqua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloned genes which encode ELAM-1
    Patent number: 5081034
    Abstract: The invention relates to cloned genes, or degenerate variants thereof, which encode endothelial-leukocyte adhesion molecule-1 (ELAM-1), or fragments thereof. Such fragments may be leukocyte or complement-binding. The invention also relates to cloned genes encoding fusion proteins comprising ELAM. The invention also relates to vectors containing the cloned genes of the invention, hosts transformed with the vectors, and the protein products expressed therefrom. The invention also relates to pharmaceutical compositions comprising the expressed proteins. The invention also relates to methods for the treatment of inflammation, post reperfusion injury, bacterial infections, vasculitis, leukemia, and methods of inhibiting metastatic spread of tumor cells by administering the pharmaceutical compositions of the invention.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: January 14, 1992
    Assignee: Brigham & Women's Hospital
    Inventors: Michael P. Bevilacqua, Michael A. Gimbrone, Brian Seed, Siegfried Stengelin