Patents by Inventor Michael P. Cava

Michael P. Cava has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of (+)-4-demethoxydaunomycinone
    Patent number: 4489206
    Abstract: It has been found that stereospecific R(-)-4-demethoxy-7-deoxydaunomycinone can be synthesized from the known compound 4-demethoxy-7,9-dideoxydaunomycinone. R(-)-4-Demethoxy-7-deoxy-daunomycinone is an intermediate in the synthesis of (+)-4-demethoxydaunomycinone, the aglycone of the nonnaturally occurring and antitumor active (-)7(S)9(S)-4-demethoxydaunorubicin.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: December 18, 1984
    Assignee: Adria Laboratories, Inc.
    Inventors: Michael P. Cava, Domingo Dominguez
  • Synthesis of 4-demethoxydaunomycinone
    Patent number: 4448724
    Abstract: A synthesis of 4-demethoxydaunomycinone and its derivatives from the known compound 9-acetyl-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione. 4-Demet hoxydaunomycinone may be converted to 4-demethoxydaunorubicin which is an anthracycline derivative known to have antitumor activity.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: May 15, 1984
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Michael P. Cava, Domingo Dominguez