Abstract: Methods of designing, generating, screening, and identifying one or more of these peptides possessing multiple functionalities, for example, including (i) high binding to a cellular target (e.g., melanin pigment in the eye), (ii) high cell-penetration (e.g., to enter cells and access melanin in the melanosomes), and (ii) low cytotoxicity have been developed. Peptides or drug conjugates thereof having these multiple functionalities are particularly effective for selective delivery, prolonged residence, and sustained release of active agents to the epithelial tissues via mucosal surfaces. Methods of using these peptides are also described.

Abstract: Construction scaffolding comprising adjacent end frames with joined vertical support members is provided with movable rung members that are extendible and retractable, that engage the exterior surface of the vertical support members, and that are secured to the support members by clamp members having quick-release threaded fasteners.