Patents by Inventor Michael P. Fleming

Michael P. Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Patent number: 6858749
    Abstract: The present invention relates to a novel process for producing a ?-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-?-lactone.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: February 22, 2005
    Assignee: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Patent number: 6818789
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: November 16, 2004
    Assignee: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Patent number: 6743927
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: June 1, 2004
    Assignee: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Publication number: 20030171602
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: 1
    Type: Application
    Filed: February 10, 2003
    Publication date: September 11, 2003
    Applicant: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Rober J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Publication number: 20030158423
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: 1
    Type: Application
    Filed: February 10, 2003
    Publication date: August 21, 2003
    Applicant: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Publication number: 20030158422
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: 1
    Type: Application
    Filed: February 10, 2003
    Publication date: August 21, 2003
    Applicant: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Mitcheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
    Patent number: 6545165
    Abstract: The present invention relates to a novel process for producing a &dgr;-lactone of the formula: using an acyl halide of the formula: wherein R1, R2 R3 and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-&dgr;-lactone.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: April 8, 2003
    Assignee: Roche Colorado Corporation
    Inventors: Michael P. Fleming, Yeun-Kwei Han, Lewis M. Hodges, David A. Johnston, Roger P. Micheli, Kurt Puentener, Chris R. Roberts, Michelangelo Scalone, Mark A. Schwindt, Robert J. Topping
  • Preparation of mibefradil via an acetamide anion
    Patent number: 5808088
    Abstract: A method of preparing 2-?2-{?3-(1H-benzimidazol-2-yl)propyl!methylamino)}ethyl!-6-fluoro-1-isopr opyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate comprises contacting 6-fluoro-1-isopropyl-3,4-dihydro-1H-naphthalen-2-one with the dianion of N-?3-(1H-benzimidazol-2-yl)propyl!-N-methylacetamide to form N-?3-(1H-benzimidazol-2-yl)propyl!-2-(6-fluoro-2-hydroxy-1-isopropyl-1,2,3 ,4-tetrahydronaphthalen-2-yl)-N-methylacetamide, reducing this to 2-?2-{?3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro-1-isopro pyl-1,2,3,4-tetrahydronaphthalen-2-ol, and treating the 2-?2-{?3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro-1-isopro pyl-1,2,3,4-tetrahydronaphthalen-2-ol with methoxyacetic acid or an activated derivative of methoxyacetic acid. The invention is particularly applicable to the preparation of mibefradil, (lS,2S)-2-?2-{?3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro- 1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, and its dihydrochloride salt.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: September 15, 1998
    Assignee: Roche Colorado Corporation
    Inventors: Peter J. Harrington, Michael P. Fleming
  • Laser welding process for attaching metal to ceramic substrate
    Patent number: 5306891
    Abstract: A metal sheet is attached to a ceramic substrate utilizing a weld pad formed of tungsten layer that is preformed onto the substrate and features a faying surface coated with a gold film. The sheet is superposed onto the gold film and scanned with a laser beam to fuse the sheet and the gold, without fusing the tungsten, thereby avoiding spalling of the metal and microcracking of the ceramic.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: April 26, 1994
    Assignee: Motorola, Inc.
    Inventors: Michael P. Fleming, Celia A. Berry, Robert W. Shisler
  • Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
    Patent number: 4937368
    Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from from di(lower alkyl) 1,3-acetone-dicarboxylates.
    Type: Grant
    Filed: January 23, 1989
    Date of Patent: June 26, 1990
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Hiralal N. Khatri, Michael P. Fleming, George C. Schloemer
  • Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds
    Patent number: 4874871
    Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds of the formula, ##STR1## in which Y is OH;O.sup.- M.sup.+, wherein M is an alkali metal; orNRR', wherein R is lower alkyl and R' is lower alkyl or aryl, or NRR' is the residue of a saturated cyclic amine,are prepared from pyrrole.
    Type: Grant
    Filed: March 25, 1987
    Date of Patent: October 17, 1989
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Michael P. Fleming, George C. Schloemer, Hiralal N. Khatri
  • Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
    Patent number: 4874872
    Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetonedicarboxylates.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: October 17, 1989
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Michael P. Fleming, Hiralal N. Khatri, George C. Schloemer
  • Process for preparing (.+-.)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
    Patent number: 4849526
    Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylate intermediates of the formula, ##STR1## in which each R is independently H or lower alkyl,are prepared from di(lower alkyl) 1,3-acetonedicarboxylates.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: July 18, 1989
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Michael P. Fleming, Hiralal N. Khatri, George C. Schloemer
  • Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
    Patent number: 4835288
    Abstract: 2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetone-dicarboxylates.
    Type: Grant
    Filed: January 14, 1987
    Date of Patent: May 30, 1989
    Assignee: Syntex Inc.
    Inventors: Hiralal N. Khatri, Michael P. Fleming, George C. Schloemer
  • Process for preparing N-vinyl carbazoles
    Patent number: 4332723
    Abstract: N-Vinyl carbazoles are prepared by reacting an N-unsubstituted carbazole with a dihaloethane in the presence of a phase transfer catalyst followed by reaction with an aqueous solution containing a highly basic agent. These N-vinyl carbazoles are useful, singly or in combination with other materials, as electrical capacitors and insulators, in thermal foam insulators, as components in copolymers and in image-recording systems, and as photoconductive materials in electrophotography.
    Type: Grant
    Filed: May 20, 1981
    Date of Patent: June 1, 1982
    Assignee: Syntex (U.S.A.) Inc.
    Inventor: Michael P. Fleming