Patents by Inventor Michael P. Gamcsik

Michael P. Gamcsik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF ACTIVATION OF OXAZAPHOSPHORINES
    Publication number: 20140243294
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicant: DUKE UNIVERSITY
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • Method of activation of oxazaphosphorines
    Patent number: 8759324
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: June 24, 2014
    Assignee: Duke University
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • Method of activation of oxazaphosphorines
    Patent number: 8399434
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: March 19, 2013
    Assignee: Duke University
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • METHOD OF ACTIVATION OF OXAZAPHOSPHORINES
    Publication number: 20120077782
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Application
    Filed: November 6, 2007
    Publication date: March 29, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • METHOD OF TREATING NEUROBLASTOMA
    Publication number: 20100104628
    Abstract: The present invention relates, in general, to neuroblastoma and, in particular, to a method of treating neuroblastoma tumors, including refractory neuroblastoma tumors. The invention also relates to compounds and compositions suitable for use in such a method.
    Type: Application
    Filed: March 28, 2008
    Publication date: April 29, 2010
    Applicant: Duke University
    Inventors: Susan M. Ludeman, Michael P. Gamcsik, Timothy A. Driscoll, James B. Springer, O. Michael Colvin, David J. Adams, Karel Base
  • METHOD OF ACTIVATION OF OXAZAPHOSPHORINES
    Publication number: 20090318388
    Abstract: The present invention provides a method of hydroxylating or oxidizing a compound of interest in a subject (e.g., a cytotoxic oxazaphosphorine prodrug), by administering the compound of interest to the subject; and concurrently administering the subject a metalloporphyrin in an amount effective to hydroxylate or oxidize the compound of interest in the subject.
    Type: Application
    Filed: November 6, 2007
    Publication date: December 24, 2009
    Applicant: DUKE UNIVERSITY
    Inventors: Ivan Spasojevic, Michael O. Colvin, Ines Batinic-Haberle, Susan M. Ludeman, Michael P. Gamcsik
  • Camptothecin compounds with a thioether group
    Patent number: 6825206
    Abstract: Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: November 30, 2004
    Assignees: Research Triangle Institute, Duke University, National Institutes of Health
    Inventors: Michael P. Gamcsik, David J. Adams, O. Michael Colvin, Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Yves Pommier