Patents by Inventor Michael P. Killoran

Michael P. Killoran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPLIT MODIFIED DEHALOGENASE VARIANTS
    Publication number: 20240174992
    Abstract: Provided herein are peptide and polypeptide sequences that structurally assemble to form active, modified dehalogenase structures capable of binding to a haloalkyl ligand. In particular, provided herein are split dehalogenase variants that assemble through structural complementation into active dehalogenase complexes, and systems and methods of use thereof.
    Type: Application
    Filed: May 4, 2023
    Publication date: May 30, 2024
    Inventors: Michael P. Killoran, Evan Glasgow, Lance P. Encell, Thomas Kirkland, Rahele Esmatpour
  • MODIFIED DEHALOGENASE WITH EXTENDED SURFACE LOOP REGIONS
    Publication number: 20240132859
    Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.
    Type: Application
    Filed: May 4, 2023
    Publication date: April 25, 2024
    Inventors: Michael P. Killoran, Lance P. Encell, Thomas Kirkland, Thomas Machleidt, Rachel Friedman Ohana, Robin Hurst, Mark A. Klein, Karilyn Porter, Rahele Esmatpour, Debayan De Bakshi
  • CIRCULARLY PERMUTED DEHALOGENASE VARIANTS
    Publication number: 20240060059
    Abstract: Provided herein are circularly-permuted (cp) dehalogenase variants that are capable of covalently binding to a haloalkyl ligand. In particular cp dehalogenase variants and peptides and polypeptides comprising split versions thereof that structurally assemble to form an active dehalogenase complexes are provided.
    Type: Application
    Filed: May 4, 2023
    Publication date: February 22, 2024
    Inventors: Michael P. Killoran, Evan Glasgow, Lance P. Encell, Thomas Kirkland, Thomas Machleidt