Patents by Inventor Michael P. Kotick

Michael P. Kotick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regioselective synthesis of mono-alkyl citric acid esters
    Patent number: 5049699
    Abstract: Disclosed are 1- and 2-mono esters of citric acid and methods for preparing them in the pure form. These novel compounds are useful as surfactants.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: September 17, 1991
    Assignee: Haarmanns' Reimer Corp
    Inventor: Michael P. Kotick
  • 7.beta.-Arylalkyl-6.alpha., 7 .alpha.-oxymethylene-3-methoxy or 3-hydroxy-4, 5.alpha.-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
    Patent number: 4443605
    Abstract: Disclosed are 7.beta.-arylalkyl substituted morphinan compounds characterized by the formula: ##STR1## In the above formula, R is H or methyl, R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl and n is 2 to 5.
    Type: Grant
    Filed: July 30, 1982
    Date of Patent: April 17, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, David L. Leland
  • 7.beta.-Arylalkyl-3-methoxy or 3-hydroxy-4,5.alpha.-epoxy-6.beta.-hydroxy-7.alpha.-hydroxymethyl-17-met hyl or 17-cycloalkylmethylmorphinans
    Patent number: 4440931
    Abstract: Disclosed are 7.beta.-alkyl or arylalkyl-3-methoxy or hydroxy-4,5.alpha.-epoxy-6.beta.-hydroxy-7.alpha.-hydroxymethyl-17-methyl or cycloalkylmethylmorphinans of the formula: ##STR1## In the above formula, R is H or methyl, R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl, n is 2 to 4 and Y is H or phenyl. These compounds are useful as narcotic analgesics.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: April 3, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, David L. Leland, Joseph O. Polazzi
  • 7.beta.-Arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-methoxy or 3-hydroxy-4,5.alpha.-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
    Patent number: 4440932
    Abstract: Disclosed are 7.beta.-arylalkyl-7.alpha.-methyl-6-oxo or 6.alpha.-hydroxy-3-methoxy or 3-hydroxy-4,5.alpha.-epoxy-17-methyl or 17-cycloalkylmethyl-morphinans of the formula: ##STR1## wherein R is H or methyl, X is oxo or .alpha.-hydroxy, n is 2 to 4 and R.sub.1 is methyl, cyclopropylmethyl or cyclobutylmethyl. These compounds are useful as strong analgesics.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: April 3, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, David L. Leland
  • 17-Cyclobutylmethyl-3-hydroxy-8.beta.-methyl-6-methylene-morphinane methanesulfonate
    Patent number: 4334071
    Abstract: Disclosed is the title compound which has been found to be significantly more water soluble than other acid addition salts of the morphinane nucleus.
    Type: Grant
    Filed: February 2, 1981
    Date of Patent: June 8, 1982
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, Joseph O. Polazzi
  • 7,7-Ditosyloxymethyl-4,5.alpha.-epoxy-morphinan-6-ols
    Patent number: 4275205
    Abstract: Disclosed are 7,7-dimethyl-4,5.alpha.-epoxy-morphinan-6-one compounds characterized by the formula: ##STR1## wherein R is H or CH.sub.3, R.sub.1 is H, CH.sub.3 or CH.sub.2 CH.sub.3 and R.sub.2 is cyclopropylmethyl or cyclobutylmethyl. Particular compounds circumscribed by the foregoing formula are useful as analgesics, narcotic antagonists or mixed analgesics/narcotic antagonists.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: June 23, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, David L. Leland
  • 7,8 and 7-8 Substituted 4,5.alpha.-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
    Patent number: 4272541
    Abstract: Disclosed are 7,8 and 7-8 substituted 4,5.alpha.-epoxymorphinan-6-one compounds characterized by the structural formula: ##STR1## In the foregoing formula R.sub.1 may be H or methyl, R.sub.2 is cyclopropylmethyl, cyclobutylmethyl, allyl or tetrahydrofurfuryl, R.sub.3 is H, .beta.-methyl, .beta.-ethyl or .alpha.-ethyl and R.sub.4 is H or .alpha.-methyl. Particular compounds corresponding to the foregoing description are useful as mixed analgesics/narcotic antagonists whereas others have been found to be pure narcotic antagonists.
    Type: Grant
    Filed: July 11, 1979
    Date of Patent: June 9, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, Robert N. Schut, Joseph O. Polazzi, David L. Leland
  • 17-Cyclobutylmethyl-3-hydroxy-.beta.-methyl-6-methylene morphinane, and methods of treating pain with them
    Patent number: 4259329
    Abstract: Disclosed are 6-methylene-morphinan compounds corresponding to the formula: ##STR1## wherein R.sub.1 and R.sub.3 are H or methyl and R.sub.2 is cyclopropylmethyl or cyclobutylmethyl. These compounds are useful as mixed analgesics/narcotic antagonists.
    Type: Grant
    Filed: April 21, 1980
    Date of Patent: March 31, 1981
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, Joseph O. Polazzi
  • 7-Methyl-8.beta.-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them
    Patent number: 4230712
    Abstract: Disclosed are 7-methyl, 8.beta.-lower alkyl and 7 methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: ##STR1## Specific compounds, included within the scope of the foregoing general formula wherein R.sub.1 is H or methyl, R.sub.2 is cyclopropylmethyl or cyclobutylmethyl, R.sub.3 is H, methyl, ethyl or n-propyl and R.sub.4 is H or methyl are useful as mixed analgesics/narcotic antagonists.
    Type: Grant
    Filed: May 21, 1979
    Date of Patent: October 28, 1980
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael P. Kotick, Robert N. Schut, Joseph O. Polazzi, David L. Leland