Patents by Inventor Michael P. Maher

Michael P. Maher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANOMALY DETECTION SYSTEMS AND METHODS
    Publication number: 20240078889
    Abstract: This disclosure relates to the analysis of data generated by one or more connected systems and devices. Operational data obtained by one or more connected devices and/or systems, such as a connected thermostat and/or wind turbine system, may be used to detect and/or predict impending failures and/or suboptimal performance. By detecting and/or predicting anomalous system and device performance, various actions may be taken to improve system and device performance and mitigate failure conditions.
    Type: Application
    Filed: November 9, 2023
    Publication date: March 7, 2024
    Applicant: Intertrust Technologies Corporation
    Inventors: David P. Maher, Michael Tamir
  • Ion channel assay methods
    Patent number: 8426201
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: April 23, 2013
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Patent number: 8071318
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: December 6, 2011
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7923537
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: April 12, 2011
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7767408
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: August 3, 2010
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7695922
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: April 13, 2010
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • ION CHANNEL ASSAY METHODS
    Publication number: 20100081163
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: September 28, 2009
    Publication date: April 1, 2010
    Applicant: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7615357
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 10, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7615356
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: November 10, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7611850
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: November 3, 2009
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • ION CHANNEL ASSAY METHODS
    Publication number: 20090253159
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: May 30, 2006
    Publication date: October 8, 2009
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7399599
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: July 15, 2008
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Patent number: 7312043
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: December 25, 2007
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Patent number: 7176016
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: February 13, 2007
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Multi-well plate and electrode assemblies for ion channel assays
    Patent number: 6969449
    Abstract: Plate and electrode assemblies include configurations allowing for relatively uniform electric field production. The electrodes may comprise strips of conductive material plated onto the bottom surface of sample wells or they may comprise plate electrodes extending down into the well. In some embodiments, the electric field strength varies by less than about 10% from a mean field intensity over at least about 20% of the surface area of the bottom surface of a sample well.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: November 29, 2005
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Publication number: 20040191757
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: February 2, 2004
    Publication date: September 30, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Publication number: 20040180426
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: February 2, 2004
    Publication date: September 16, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • Ion channel assay methods
    Publication number: 20040110123
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: July 14, 2003
    Publication date: June 10, 2004
    Inventors: Michael P. Maher, Jesus E. Gonzalez
  • High throughput method and system for screening candidate compounds for activity against target ion channels
    Patent number: 6686193
    Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: February 3, 2004
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Michael P. Maher, Jesus E. Gonzalez, III
  • Ion channel assay methods
    Publication number: 20020045159
    Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
    Type: Application
    Filed: March 12, 2001
    Publication date: April 18, 2002
    Inventors: Michael P. Maher, Jesus E. Gonzalez