Patents by Inventor Michael P. Malakhov

Michael P. Malakhov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TECHNOLOGY FOR PREPARATION OF MACROMOLECULAR MICROSPHERES
    Publication number: 20150290134
    Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
    Type: Application
    Filed: April 21, 2015
    Publication date: October 15, 2015
    Inventors: Michael P. Malakhov, Fang Fang
  • Technology for the Preparation of Microparticles
    Publication number: 20150050713
    Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
    Type: Application
    Filed: July 25, 2014
    Publication date: February 19, 2015
    Inventors: Michael P. Malakhov, Fang Fang
  • Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract
    Publication number: 20150017150
    Abstract: The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.
    Type: Application
    Filed: September 17, 2014
    Publication date: January 15, 2015
    Inventors: Fang Fang, David Wurtman, Ron Moss, Michael P. Malakhov
  • TECHNOLOGY FOR PREPARATION OF MACROMOLECULAR MICROSPHERES
    Publication number: 20140134150
    Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 15, 2014
    Applicant: Ansun Biopharma, Inc.
    Inventors: Michael P. Malakhov, Fang Fang
  • Class of therapeutic protein based molecules
    Patent number: 8722869
    Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: May 13, 2014
    Assignee: Ansun Biopharma, Inc.
    Inventors: Fang Fang, Michael P. Malakhov
  • Technology for the Preparation of Microparticles
    Publication number: 20140099696
    Abstract: Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals, nutraceuticals, cosmetic products and the like of defined dimensions.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 10, 2014
    Applicant: Ansun Biopharma, Inc.
    Inventors: Michael P. Malakhov, Fang Fang
  • Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture
    Publication number: 20140099380
    Abstract: Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
    Type: Application
    Filed: June 28, 2013
    Publication date: April 10, 2014
    Inventors: Michael P. Malakhov, Tiejun Li
  • Technology for preparation of macromolecular microspheres
    Patent number: 8623419
    Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: January 7, 2014
    Assignee: Ansun Biopharma, Inc.
    Inventors: Michael P. Malakhov, Fang Fang
  • Novel Class of Therapeutic Protein Based Molecules
    Publication number: 20130337540
    Abstract: The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeutic domain that can act extracellularly to prevent infection of a target cell by a pathogen, such as a virus. The present invention also comprises therapeutic compositions having sialidase activity, including protein-based compounds having sialidase catalytic domains. Compounds of the invention can be used for treating or preventing pathogen infection, and for treating and reducing allergic and inflammatory responses. The invention also provides compositions and methods for enhancing transduction of target cells by recombinant viruses. Such compositions and methods can be used in gene therapy.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 19, 2013
    Applicant: Ansun Biopharma, Inc.
    Inventors: Fang Fang, Michael P. Malakhov
  • Methods, compounds, and compositions for treatment and prophylaxis in the respiratory tract
    Patent number: 8398971
    Abstract: The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: March 19, 2013
    Assignee: NexBio, Inc.
    Inventors: Fang Fang, David Wurtman, Ron Moss, Michael P. Malakhov
  • TECHNOLOGY FOR PREPARATION OF MACROMOLECULAR MICROSPHERES
    Publication number: 20120116062
    Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
    Type: Application
    Filed: November 4, 2011
    Publication date: May 10, 2012
    Inventors: Michael P. Malakhov, Fang Fang
  • Methods, Compounds, and Compositions for Treatment and Prophylaxis in the Respiratory Tract
    Publication number: 20110171132
    Abstract: The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes administering to the subject a compound or composition containing a therapeutically effective amount of a fusion protein comprising a sialidase or an active portion thereof and an anchoring domain. The therapeutically effective amount comprises an amount of the fusion protein that results in a reduction of the quanitity of mucus in the respiratory tract after administration of the compound or composition when compared to the quantity of mucus present prior to administration of the compound or composition.
    Type: Application
    Filed: November 5, 2010
    Publication date: July 14, 2011
    Applicant: NexBio, Inc.
    Inventors: Fang Fang, David Wurtman, Ron Moss, Michael P. Malakhov
  • Methods and compositions for protein expression and purification
    Patent number: 7820384
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: October 26, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Míchael P. Malakhov, Oxana A. Malakhova
  • Technology for Preparation of Macromolecular Microspheres
    Publication number: 20100166874
    Abstract: Microspheres are produced by contacting an aqueous solution of a protein or other macromolecule with an organic solvent and a counterion, and chilling the solution. The microspheres are useful for preparing pharmaceuticals of defined dimensions.
    Type: Application
    Filed: December 8, 2009
    Publication date: July 1, 2010
    Inventors: Michael P. Malakhov, Fang Fang
  • Methods and compositions for enhanced protein expression and purification
    Patent number: 7655413
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: June 28, 2004
    Date of Patent: February 2, 2010
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Oxana A. Malakhova, Michael P. Malakhov
  • Methods and compositions for protein expression and purification
    Patent number: 7220576
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: March 14, 2003
    Date of Patent: May 22, 2007
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for protein expression and purification
    Patent number: 7060461
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Grant
    Filed: January 7, 2003
    Date of Patent: June 13, 2006
    Assignee: Lifesensors, Inc.
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for protein expression and purification
    Publication number: 20040018591
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: March 14, 2003
    Publication date: January 29, 2004
    Inventors: Tauseef R. Butt, Stephen D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova
  • Methods and compositions for protein expression and purification
    Publication number: 20030153045
    Abstract: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.
    Type: Application
    Filed: January 7, 2003
    Publication date: August 14, 2003
    Inventors: Tauseef R. Butt, Steven D. Weeks, Hiep T. Tran, Michael P. Malakhov, Oxana A. Malakhova