Patents by Inventor Michael P. McRae

Michael P. McRae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12235272
    Abstract: The present disclosure is related to systems and methods to be used as aids in the diagnosis of risk for oral cancer, potentially malignant oral lesion (PMOL), and/or oral epithelial dysplasia (OED) by identifying cellular phenotype characteristics of cell samples, including percentage of mature squamous cells, presence or absence of nuclear actin in mature squamous cells, percentage of non-mature squamous cells, percentage of small round cells, percentage of white blood cells, and percentage of lone nuclei.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: February 25, 2025
    Assignee: New York University
    Inventors: John T. McDevitt, Michael P. McRae
  • Publication number: 20240302373
    Abstract: Aspects of the present invention relate to a method of assessing disease in a subject comprising identifying at least one cellular phenotype characteristic of one or more cells in a sample of the subject, identifying at least one clinical characteristic of the subject, using the at least one cellular phenotype characteristic and the at least one clinical characteristic to assess a presence of oral lichenoid conditions (OLC) in the subject. In some embodiments, the OLC is oral lichen planus (OLP) and oral lichenoid lesions (OLL). In some embodiments, the at least one clinical characteristic is selected from the group consisting of: lesion involvement, lesion appearance, lesion area, lesion color and lesion location.
    Type: Application
    Filed: March 11, 2024
    Publication date: September 12, 2024
    Inventors: John T. McDevitt, Michael P. McRae, Kritika S. Rajsri
  • Publication number: 20240175881
    Abstract: Simplified methods are provided for determining liver function based on a Compartmental Model (CM) method for analysis of various hepatic indices including cholate SHUNT test which closely approximates and elucidates the underlying physiology of hepatic uptake of cholate from systemic and portal circulations simultaneously.
    Type: Application
    Filed: November 2, 2023
    Publication date: May 30, 2024
    Inventors: Michael P. McRae, Steve Mark Helmke, Gregory Thomas Everson
  • Publication number: 20240062912
    Abstract: Methods are provided for determining liver function based on a Compartmental Model (CM) method for analysis of cholate SHUNT test data which closely approximates and elucidates the underlying physiology of hepatic uptake of cholate from systemic and portal circulations simultaneously.
    Type: Application
    Filed: August 8, 2023
    Publication date: February 22, 2024
    Inventors: Michael P. McRae, Steve Mark Helmke, Gregory Thomas Everson
  • Publication number: 20230375587
    Abstract: The present invention provides devices and methods that precisely control the flow of fluids. In various embodiments, the present invention relates to devices and methods configured to optically track fluid flow into and through an optically monitored region or regions and to adjust fluid flow based on parameters detected within the optically monitored region or regions. In various embodiments, the devices and methods of the present invention pertain to the control of fluids in microfluidic chip systems.
    Type: Application
    Filed: May 17, 2023
    Publication date: November 23, 2023
    Inventors: John T. McDevitt, Michael P. McRae
  • Publication number: 20220334115
    Abstract: The present disclosure is related to systems and methods to be used as aids in the diagnosis of risk for carcinoma, lesions, or dysplasia by identifying cellular phenotype characteristics of cell samples, including percentage of mature squamous cells, presence or absence of nuclear actin in mature squamous cells, percentage of non-mature squamous cells, percentage of small round cells, percentage of white blood cells, and percentage of lone nuclei.
    Type: Application
    Filed: May 4, 2022
    Publication date: October 20, 2022
    Inventors: John T. McDevitt, Michael P. McRae
  • Publication number: 20210311055
    Abstract: This disclosure describes portable bio-nano-chip assays, methods and compositions for diagnosing and assessing pathogen-mediated diseases or infections at point-of-care using biological samples. The assays, methods and compositions provide in a more convenient, less expensive, and less time-consuming sampling and analysis.
    Type: Application
    Filed: March 25, 2021
    Publication date: October 7, 2021
    Inventors: John T. McDevitt, Michael P. McRae, Nick Christodoulides, Kritika Srinivasan
  • Publication number: 20210215703
    Abstract: The present disclosure is related to systems and methods to be used as aids in the diagnosis of risk for oral cancer, potentially malignant oral lesion (PMOL), and/or oral epithelial dysplasia (OED) by identifying cellular phenotype characteristics of cell samples, including percentage of mature squamous cells, presence or absence of nuclear actin in mature squamous cells, percentage of non-mature squamous cells, percentage of small round cells, percentage of white blood cells, and percentage of lone nuclei.
    Type: Application
    Filed: January 13, 2021
    Publication date: July 15, 2021
    Inventors: John T. McDevitt, Michael P. McRae