Abstract: A package that is suitable for packaging an article for collecting or administering a pharmaceutical active substance is disclosed. The package includes a first packaging component that includes a product-contacting sealant layer that includes a first ethylene vinyl alcohol copolymer. The package includes a second packaging component that includes a product-contacting sealant layer that includes a second ethylene vinyl alcohol copolymer. The ethylene content of the second ethylene vinyl alcohol copolymer is equal to or less than about 38 percent and the ethylene content of the first ethylene vinyl alcohol copolymer is greater than the ethylene content of the second ethylene vinyl alcohol copolymer.

Abstract: A humeral head assembly is provided that includes an articular body and a coupler. The articular body includes a coupling portion disposed on a side of the articular body opposite an articular surface. The coupling portion includes a continuous zone of eccentricity adjustment. The coupler portion optionally includes one or more than one discrete position site. The coupler includes a first portion and a second portion opposite the first portion. The first portion is configured to mate with the coupling portion and the second portion is configured to mate with another member of a joint prosthesis. A coupling portion with the continuous range of eccentricity adjustment can be provided on a bone anchor and the eccentricity of another component can be selected by motion of a coupler, such as a tray for reverse humeral assemblies, along the coupling portion of the anchor.

Abstract: A valve includes at least one valve stem seal, such as a packing seal, that is included in a removable seal cartridge. The valve stem is connected to the actuator via a linkage, which can be removed to provide a linkage gap between the actuator and the valve stem. The seal cartridge can then be slid along the valve stem into the linkage gap and laterally removed from the valve, whereupon the seals within the seal cartridge can be refurbished. The valve can be a rotary or linear valve. In embodiments, the linkage gap can be increased by linear displacement of the actuator away from the valve stem. The seal cartridge can be re-installed in the valve after refurbishment, or a substantially identical replacement seal cartridge can be provided, and can be installed in the valve in replacement of the removed seal cartridge, thereby minimizing downtime of the valve.

Abstract: A valve system for controlling a corrosive process liquid flow, while avoiding corrosion due to a liquid/vapor interface of the process liquid, causes the process liquid to flow from the valve through a purge port into a vertical segment of a purge line. During valve initialization, a non-reactive gas backpressure within the purge line is controlled to establish the liquid/vapor interface at a desired height within the vertical segment, as determined by an interface level sensor, which can be ultrasonic. The vertical segment is constructed from, or lined with, a material that can withstand contact with the liquid/vapor interface. During valve operation, the non-reactive gas pressure can continue to be regulated, or a purge valve can be shut, trapping a fixed quantity of the non-reactive gas within the purge line. The valve can include a heater configured to prevent a molten process liquid from solidifying within the valve.

Abstract: A valve configured to control a flow of a process fluid includes a pair of packing seals separated by a seal gap space along a linear valve stem of the valve, and a pressurization port that can be used to apply a pressurizing fluid, such as nitrogen gas, to the seal gap at a gap pressure that is higher than the process fluid pressure, thereby ensuring that any leakage past the packing seals will be of pressurizing fluid into the process fluid and/or into the environment, and that no process fluid will escape into the environment. The pressure or flow rate of the pressurizing fluid can be monitored to detect and quantify any pressurization fluid leakage past either of the packing seals, so that a maintenance action can be applied to the valve, such as re-tightening or replacing at least one of the packing seals, or replacing the valve.

Abstract: A valve for controlling a molten liquid includes an expansion port in liquid communication with an internal volume of the valve that is filled with the molten liquid. An expansion valve can be opened during unfreezing of the valve, to allow melting process substance to expand out of the internal volume into an expansion line as it is melted. During initialization of the valve, an inert gas source, pressure regulator, and ultrasonic transition level sensor can be used to establish a liquid/gas interface at a desired height within the expansion line. The valve can include a multi-zone heater, wherein a first of the zones is adjacent the expansion port, so that during unfreezing, after the first zone has been melted, the remaining zones can be sequentially activated in an order that ensures that each zone is activated only after an adjacent zone has been melted.

Abstract: An apparatus for measuring a pressure of a corrosive or high temperature process liquid includes a pressure sensor in communication with the process liquid via a vertical tube. A buffer gas injected into the vertical tube forms a liquid/gas interface at a desired height. The buffer gas supply is then either isolated or regulated so as to cause the buffer gas pressure within the vertical tube to remain equal with the process liquid pressure. The pressure sensor indirectly measures the process liquid pressure by measuring the buffer gas pressure within the vertical tube, while remaining chemically and thermally protected from the process liquid. In embodiments, pressure measurements from a pair of gas buffered pressure sensors located upstream and downstream of a valve are combined with measurements of the process liquid temperature to determine a flow rate of the process liquid through the valve.

Abstract: A valve for controlling a molten liquid includes an expansion port in liquid communication with an internal volume of the valve that is filled with the molten liquid. An expansion valve can be opened during unfreezing of the valve, to allow melting process substance to expand out of the internal volume into an expansion line as it is melted. During initialization of the valve, an inert gas source, pressure regulator, and ultrasonic transition level sensor can be used to establish a liquid/gas interface at a desired height within the expansion line. The valve can include a multi-zone heater, wherein a first of the zones is adjacent the expansion port, so that during unfreezing, after the first zone has been melted, the remaining zones can be sequentially activated in an order that ensures that each zone is activated only after an adjacent zone has been melted.

Abstract: A valve system for controlling a corrosive process liquid flow, while avoiding corrosion due to a liquid/vapor interface of the process liquid, causes the process liquid to flow from the valve through a purge port into a vertical segment of a purge line. During valve initialization, a non-reactive gas backpressure within the purge line is controlled to establish the liquid/vapor interface at a desired height within the vertical segment, as determined by an interface level sensor, which can be ultrasonic. The vertical segment is constructed from, or lined with, a material that can withstand contact with the liquid/vapor interface. During valve operation, the non-reactive gas pressure can continue to be regulated, or a purge valve can be shut, trapping a fixed quantity of the non-reactive gas within the purge line. The valve can include a heater configured to prevent a molten process liquid from solidifying within the valve.

Abstract: A valve configured to control a flow of a process fluid includes a pair of packing seals separated by a seal gap space along a linear valve stem of the valve, and a pressurization port that can be used to apply a pressurizing fluid, such as nitrogen gas, to the seal gap at a gap pressure that is higher than the process fluid pressure, thereby ensuring that any leakage past the packing seals will be of pressurizing fluid into the process fluid and/or into the environment, and that no process fluid will escape into the environment. The pressure or flow rate of the pressurizing fluid can be monitored to detect and quantify any pressurization fluid leakage past either of the packing seals, so that a maintenance action can be applied to the valve, such as re-tightening or replacing at least one of the packing seals, or replacing the valve.

Abstract: An apparatus for measuring a pressure of a corrosive or high temperature process liquid includes a pressure sensor in communication with the process liquid via a vertical tube. A buffer gas injected into the vertical tube forms a liquid/gas interface at a desired height. The buffer gas supply is then either isolated or regulated so as to cause the buffer gas pressure within the vertical tube to remain equal with the process liquid pressure. The pressure sensor indirectly measures the process liquid pressure by measuring the buffer gas pressure within the vertical tube, while remaining chemically and thermally protected from the process liquid. In embodiments, pressure measurements from a pair of gas buffered pressure sensors located upstream and downstream of a valve are combined with measurements of the process liquid temperature to determine a flow rate of the process liquid through the valve.

Abstract: A valve includes at least one valve stem seal, such as a packing seal, that is included in a removable seal cartridge. The valve stem is connected to the actuator via a linkage, which can be removed to provide a linkage gap between the actuator and the valve stem. The seal cartridge can then be slid along the valve stem into the linkage gap and laterally removed from the valve, whereupon the seals within the seal cartridge can be refurbished. The valve can be a rotary or linear valve. In embodiments, the linkage gap can be increased by linear displacement of the actuator away from the valve stem. The seal cartridge can be re-installed in the valve after refurbishment, or a substantially identical replacement seal cartridge can be provided, and can be installed in the valve in replacement of the removed seal cartridge, thereby minimizing downtime of the valve.

Abstract: A bellows seal valve includes a pressurization port that can be used to apply a compensating pressure to the “atmosphere” side of the bellows, i.e. the side of the bellows that is opposite to the process fluid. The atmosphere side can be on the interior or exterior of the bellows. The compensating pressure can be greater than the process fluid pressure, to ensure that any leakage will be of pressurizing fluid into the process fluid or into the environment, and that no process fluid will escape into the environment. The pressure or flow rate of the pressurizing fluid can be monitored to detect bellows and packing leaks. A pressurizing fluid exit port can be provided, so that the pressurizing fluid can be circulated through the valve, thereby moderating the bellows temperature under conditions of extreme process fluid temperature.

Abstract: A pneumatically controlled flow booster includes a booster valve plug position sensor that enables control of the flow booster in a feedback loop, for example by a pneumatic valve positioner, thereby providing accurate, high speed, high flow control of both small and large actuator adjustments. Embodiments can accurately control a surge suppression valve over extended valve adjustment ranges and can fully open a surge suppression valve during a trip. The flow booster valve can include a spool and sleeve valve and/or a poppet valve. Embodiments provide bimodal flow boosting, whereby the output flow is less dependent on the valve plug position in a first position range, and more strongly dependent on the valve plug position in a second range.

Abstract: A plug assembly includes a plug stem having a plug stem base, a plug head, and a fastening mechanism for fastening the plug stem base to the plug head, the fastening mechanism comprising at least two retainer clamps that surround and provide an interference fit between the plug stem base and the plug head. A method of replacing or attaching a plug head to a plug stem includes providing a plug stem having a plug stem base, providing a plug head, providing a fastening mechanism comprising at least two retainer clamps, and coupling the fastening mechanism around the plug stem base and the plug head to provide an interference fit between the plug stem base and the plug head.

Abstract: Positioner assemblies may be configured to sense at least one position of at least a portion of a valve assembly that is moved along a first axis of movement. A movable element of the positioner assembly is configured to rotate about a second axis of movement, where the first axis of movement is substantially parallel to the second axis of movement. Valve systems and methods of sensing a position of a component of a valve system may include such a positioner assembly.

Abstract: Positioner assemblies may be configured to sense at least one position of at least a portion of a valve assembly that is moved along a first axis of movement. A movable element of the positioner assembly is configured to rotate about a second axis of movement, where the first axis of movement is substantially parallel to the second axis of movement.

Abstract: A plug assembly includes a plug stem having a plug stem base, a plug head, and a fastening mechanism for fastening the plug stem base to the plug head, the fastening mechanism comprising at least two retainer clamps that surround and provide an interference fit between the plug stem base and the plug head. A method of replacing or attaching a plug head to a plug stem includes providing a plug stem having a plug stem base, providing a plug head, providing a fastening mechanism comprising at least two retainer clamps, and coupling the fastening mechanism around the plug stem base and the plug head to provide an interference fit between the plug stem base and the plug head.

Abstract: Butterfly valves comprise a valve seat comprising a generally S-shaped cross-section and a valve seat retainer configured with appropriately shaped cooperating surfaces. Fluid control systems comprising such a butterfly valve are also disclosed.

Abstract: A plug assembly includes a plug stem having a plug stem base, a plug head, and a fastening mechanism for fastening the plug stem base to the plug head, the fastening mechanism comprising at least two retainer clamps that surround and provide an interference fit between the plug stem base and the plug head. A method of replacing or attaching a plug head to a plug stem includes providing a plug stem having a plug stem base, providing a plug head, providing a fastening mechanism comprising at least two retainer clamps, and coupling the fastening mechanism around the plug stem base and the plug head to provide an interference fit between the plug stem base and the plug head.