Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: A processing machine (10) for building an object (11) from powder (12) includes a build platform (26A); a powder supply assembly (18) that deposits the powder (12) onto the build platform (26A) to form a powder layer (13); and an energy system (22) that directs an energy beam (22D) at a portion of the powder (12) on the build platform (26A) to form a portion of the object (11). The powder supply assembly (18) can include (i) a powder container (640A) that retains the powder (12); (ii) a supply outlet (639) positioned over the build platform (26A); and (ii) a flow control assembly (642) that selectively controls the flow of the powder (12) from the supply outlet (639).

Abstract: The present disclosure relates to aerosol delivery devices, methods of producing such devices, and elements of such devices. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in a reservoir and transported to a heating element by a liquid transport element. The liquid transport element may include a porous monolith.

Abstract: A steering column assembly includes a steering column pivotably coupled to a rake bracket at a first pivot point, a rake locking mechanism including a rotatable rake bolt, and a multi-link assembly including a first member, a second member and a third member. The first member includes a first end fixedly coupled to the rotatable rake bolt and the second end rotatably coupled to a first end of the second member. The second member includes a second end rotatably coupled to a first end of a link portion of the third member. The third member includes a link coupled to a lever. A first end of the lever is coupled to a second end of the link. The lever includes a thumb pad. Rotation of the thumb pad around a second pivot point effects rotation of the rotatable rake bolt to lock or unlock the rake locking mechanism.

Abstract: A steering column assembly includes a steering column pivotably coupled to a rake bracket at a first pivot point, a rake locking mechanism including a rotatable rake bolt, and a multi-link assembly including a first member, a second member and a third member. The first member includes a first end fixedly coupled to the rotatable rake bolt and the second end rotatably coupled to a first end of the second member. The second member includes a second end rotatably coupled to a first end of a link portion of the third member. The third member includes a link coupled to a lever. A first end of the lever is coupled to a second end of the link. The lever includes a thumb pad. Rotation of the thumb pad around a second pivot point effects rotation of the rotatable rake bolt to lock or unlock the rake locking mechanism.

Abstract: An adjustable steering column assembly includes a steering column and a lever moveable between an unlocked position and a locked position. The position of the steering column is adjustable when the lever is in the unlocked position and fixed when the lever is in the locked position. An anti-unlocking device is provided to prevent the lever from moving to the unlocked position from the locked position when a first force is applied to the steering column. The anti-unlocking device prohibits adjustment of the steering column when a first force is applied to the steering column. An example anti-unlocking device may include a member defining a slot, with the lever being at least partially insertable in the slot in the unlocked and locked positions. The member includes a wall defining a ramp surface configured to abut at least one surface of the lever when the first force is applied.

Abstract: An apparatus and process for supplying ozonated rinse water in a closed loop recirculating system to a rinsing apparatus for articles is described. The apparatus provides a pressure differential bypass line for providing a constant recirculating flow of ozonated water from a venturi directly to a water storage tank, bypassing the rinsing apparatus. Also included are a supply line to the rinsing apparatus and a diverted supply line for diverting flow back to the storage tank and bypassing the rinsing apparatus. The supply line and the diverted supply line have a normally closed solenoid valve and a normally open solenoid valve, respectively, for controlling the flow of ozonated water between them and maintaining and regulating pressure and volume of water for optimizing injection of ozone into the water and for maintaining ozone in the water.