Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: Light-emitting devices including solid-state light-emitting devices, light-emitting diode (LED) devices, and LED packages with support elements for improved near-field and far-field emissions are disclosed. LED chips may be mounted to support elements in a manner that directs light through the support elements in desired emission directions. Support elements include optical structures that spread and mix light laterally within the support element. Optical structures include various light-altering layers, such as light-diffusing layers or light-reflective layers, that are arranged to effectively increase internal reflections for lateral spreading of light. Patterned arrangements of light-altering layers include portions that mask direct emissions for LED chips, thereby redistributing emissions laterally to increase near-field and/or far-field uniformity across an increased portion of emitting surfaces.

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: An internal combustion engine includes a cylinder head with an exhaust manifold configured to supply exhaust gas through a main exhaust outlet to a main exhaust aftertreatment system having a main catalytic converter, a bypass passage in fluid communication with the exhaust manifold via a bypass port, a bypass catalytic converter disposed within the bypass passage, and a dual-acting valve assembly configured to move between a first position that seals the bypass port, and a second position that seals the main exhaust outlet. During cold start, long idle, and/or low main catalytic converter temperature conditions, the dual-active valve assembly is moved to the second position to direct exhaust flow through the bypass passage and the bypass catalytic converter to reduce emissions.

Abstract: A cylinder head assembly includes a cast cylinder head and a turbocharger housing integrally cast with the cylinder head. The integrated cylinder head and turbocharger housing includes: (i) a compact low wetted area to provide an uninterrupted flow path pointed directly at a catalyst face to facilitate achieving cold start emissions targets, (ii) a casting core assembly with specific core geometry and steps for assembly to enable core assembly while meeting all cylinder head and integrated turbine housing functional requirements, (iii) an oxygen sensor disposed pre-turbine in an integrated exhaust manifold, and (iv) a fully integrated PCV make-up air system.

Abstract: A cylinder head assembly for an internal combustion engine includes a cast cylinder head, a turbocharger housing including a compressor housing and turbine housing integrally cast with the cylinder head, and a turbocharger cartridge assembly configured to be inserted into the turbocharger housing and including a shaft coupled between a compressor wheel and a turbine wheel. A compressor cover is configured to couple to the compressor housing and define a compressor inlet and at least partially define a compressor diffuser passage. The cartridge assembly includes a housing having a diffuser flange extending outwardly therefrom, the diffuser flange including a front surface and an opposite contoured volute surface. The compressor diffuser passage is at least partially defined by the compressor cover and the diffuser flange front surface. A compressor volute is at least partially defined by the diffuser flange contoured volute surface and a contoured inner surface of the compressor housing.

Abstract: A cylinder head assembly for an internal combustion engine includes a cast cylinder head and a turbocharger housing integrally cast with the cylinder head and having an integrally cast wastegate housing. The turbocharger housing is configured to receive a turbocharger cartridge rotatably supporting a shaft coupled between a compressor wheel and a turbine wheel. The integrally cast wastegate housing defines a wastegate chamber configured to receive a wastegate valve, a flow of exhaust gas from the turbine wheel, and a flow of wastegate exhaust gas.

Abstract: An electronic component bonding machine is provided. The electronic component bonding machine includes: a support structure for supporting a substrate; a bond head assembly for holding an electronic component, and for bonding the electronic component to the substrate; and a measuring system for measuring a distance between (i) an upper target on the electronic component bonding machine and (ii) a lower target on the electronic component bonding machine, the upper target including at least one of a portion of the bond head assembly and the electronic component, the lower target including at least one of a portion of the support structure and the substrate.

Abstract: A cylinder head assembly for an internal combustion engine includes a cast cylinder head having at least one oil gallery, a turbocharger housing integrally cast with the cylinder head, and a turbocharger cartridge assembly configured to be inserted into the turbocharger housing and including at least one bearing rotatably supporting a shaft coupled between a compressor wheel and a turbine wheel. A lubricant passage is formed within the turbocharger housing and configured to supply oil from the at least one oil gallery to the turbocharger cartridge assembly to lubricate the at least one bearing. A seal assembly is disposed at least partially within the turbocharger housing to receive lubricant from the lubricant passage and includes a sealing end configured to seal against the turbocharger cartridge assembly.

Abstract: A cylinder head assembly includes a cast cylinder head and a turbocharger housing integrally cast with the cylinder head. The integrated cylinder head and turbocharger housing includes: (i) a compact low wetted area to provide an uninterrupted flow path pointed directly at a catalyst face to facilitate achieving cold start emissions targets, (ii) a casting core assembly with specific core geometry and steps for assembly to enable core assembly while meeting all cylinder head and integrated turbine housing functional requirements, (iii) an oxygen sensor disposed pre-turbine in an integrated exhaust manifold, and (iv) a fully integrated PCV make-up air system.

Abstract: An air induction system for a vehicle includes a turbocharger having a compressor side inlet and a bifurcated clean air intake system having a bifurcated conduit. The bifurcated conduit includes an upstream end configured to receive intake air, a downstream end configured to supply intake air to the compressor side inlet, an inner passage configured to supply intake air to the downstream end, and an outer passage disposed about the inner passage and separated from the inner passage by an inner wall, the outer passage configured to selectively receive recirculation backflow from the compressor side inlet. A port is fluidly coupled between the outer passage and another location of the vehicle. The port is configured to selectively evacuate at least a portion of the recirculation backflow to the another location the vehicle.

Abstract: A cylinder head assembly for an internal combustion engine includes a cast cylinder head having at least one oil gallery, a turbocharger housing integrally cast with the cylinder head, and a turbocharger cartridge assembly configured to be inserted into the turbocharger housing and including at least one bearing rotatably supporting a shaft coupled between a compressor wheel and a turbine wheel. A lubricant passage is formed within the turbocharger housing and configured to supply oil from the at least one oil gallery to the turbocharger cartridge assembly to lubricate the at least one bearing. A seal assembly is disposed at least partially within the turbocharger housing to receive lubricant from the lubricant passage and includes a sealing end configured to seal against the turbocharger cartridge assembly.

Abstract: An air induction system for a vehicle includes a turbocharger having a compressor side inlet and a bifurcated clean air intake system having a bifurcated conduit. The bifurcated conduit includes an upstream end configured to receive intake air, a downstream end configured to supply intake air to the compressor side inlet, an inner passage configured to supply intake air to the downstream end, and an outer passage disposed about the inner passage and separated from the inner passage by an inner wall, the outer passage configured to selectively receive recirculation backflow from the compressor side inlet. A port is fluidly coupled between the outer passage and another location of the vehicle. The port is configured to selectively evacuate at least a portion of the recirculation backflow to the another location the vehicle.

Abstract: A cylinder head assembly for an internal combustion engine includes a cast cylinder head having at least one oil gallery, a turbocharger housing integrally cast with the cylinder head, and a turbocharger cartridge assembly configured to be inserted into the turbocharger housing and including at least one bearing rotatably supporting a shaft coupled between a compressor wheel and a turbine wheel. A lubricant supply system having a lubricant passage formed within the turbocharger housing is configured to supply oil from the at least one oil gallery to the turbocharger cartridge assembly to lubricate the at least one bearing.