Patents by Inventor Michael P. Thelen

Michael P. Thelen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered microorganisms having resistance to ionic liquids
    Patent number: 10370418
    Abstract: The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids using a yeast Major Facilitator Superfamily (MFS), or a Salmonella MFS SmvA Pump or SmvR Regulator, a Small Multidrug Resistance Family (SMR), or Saccharomyces cerevisiae YDR090C, polypeptide, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: August 6, 2019
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Michael P. Thelen, Douglas A. Higgins, Thomas L. Ruegg
  • Engineered Microorganisms Having Resistance to Ionic Liquids
    Publication number: 20160090405
    Abstract: The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids using a yeast Major Facilitator Superfamily (MFS), or a Salmonella MFS SmvA Pump or SmvR Regulator, a Small Multidrug Resistance Family (SMR), or Saccharomyces cerevisiae YDR090C, polypeptide, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
    Type: Application
    Filed: May 20, 2015
    Publication date: March 31, 2016
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: Michael P. Thelen, Douglas A. Higgins, Thomas L. Ruegg
  • Engineered microorganisms having resistance to ionic liquids
    Patent number: 9290768
    Abstract: The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: March 22, 2016
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Thomas Lawrence Ruegg, Michael P. Thelen
  • ENGINEERED MICROORGANISMS HAVING RESISTANCE TO IONIC LIQUIDS
    Publication number: 20140038848
    Abstract: The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
    Type: Application
    Filed: July 3, 2013
    Publication date: February 6, 2014
    Applicant: Lawrence Livermore National Security, LLC
    Inventors: Thomas Lawrence Ruegg, Michael P. Thelen
  • Functionalized apertures for the detection of chemical and biological materials
    Patent number: 7851203
    Abstract: Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: December 14, 2010
    Assignee: Lawrence Livermore National Security, LLC
    Inventors: Sonia E. Létant, Anthony W. van Buuren, Louis J. Terminello, Michael P. Thelen, Louisa J. Hope-Weeks, Bradley R. Hart
  • Mars exploration rover athena
    Patent number: D487715
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: March 23, 2004
    Assignee: California Institute of Technology
    Inventors: Randel Lindemann, Richard A. Rainen, John Cardone, Richard G. Webster, Christopher Voorhees, James Stone, Joseph P. Melko, Paul Karlmann, Kobie Boykins, Brian Harrington, Lawrence Lee, Jason Suchman, Satish Krishnan, Keith Novak, Lori Shiraishi, Mary E. Reaves, Michael P. Thelen, Annette K. Nasif, Joseph Vacchione, Kevin Burke
  • Mars exploration rover Athena
    Patent number: D488093
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: April 6, 2004
    Assignee: California Institute of Technology
    Inventors: Randel Lindemann, Richard A. Rainen, Christopher Voorhees, James Stone, Joseph P. Melko, Paul Karlmann, Kobie Boykins, Brian Harrington, Lawrence Lee, Jason Suchman, Satish Krishnan, Lori Shiraishi, Michael P. Thelen, Annette K. Nasif, Joseph Vacchione, Kevin Burke