Patents by Inventor Michael Pack

Michael Pack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
    Publication number: 20020162124
    Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism. The present invention is a mutant fish containing a metabolic defect affecting phospholipid and cholesterol processing. The mutant fish is useful for studying phospholipid and cholesterol metabolism and for screening compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.
    Type: Application
    Filed: January 30, 2002
    Publication date: October 31, 2002
    Inventors: Steven Farber, Michael Pack
  • High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
    Publication number: 20020049986
    Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.
    Type: Application
    Filed: October 10, 2001
    Publication date: April 25, 2002
    Inventors: Steven Farber, Michael Pack, Marnie Halpern
  • Compositions and methods for detecting altered COL1A1 gene sequences
    Patent number: 6265157
    Abstract: Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the existence in a subject of a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided, wherein such pathological conditions include diseases and disorders which are known to be associated with an altered gene encoding a Type I or Type IX collagen protein chain. Primers, probes, and methods of detecting a genetic predisposition of a subject for a pathological condition associated with an altered gene encoding a Type I or Type IX collagen protein chain are provided.
    Type: Grant
    Filed: October 3, 1997
    Date of Patent: July 24, 2001
    Assignees: Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu
    Inventors: Darwin J. Prockop, Loretta D. Spotila, Constantinos D. Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala-Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta