Abstract: The present application relates to conjugates comprising an amatoxin, a target-binding moiety wherein the target is CD37, i.e., a CD37-binding moiety, and optionally a linker linking said amatoxin and said CD37-binding moiety. The invention further relates to the synthesis of said conjugates. In addition, the invention relates to a pharmaceutical composition comprising such conjugate for use in the treatment of immune cell, particularly B-cell and/or lymphoma associated diseases and/or malignancies (FIG. 1).

Abstract: A massage device for massaging by means of pressure waves includes a housing having a handle segment and a massage segment and at least one chamber comprising an opening leading outward in the massage segment. The chamber includes an end wall segment, a first circumferential wall segment, and a second circumferential wall segment, the first circumferential wall segment being disposed between the end wall segment and the second circumferential wall segment, and the second circumferential wall segment defining the opening with the end wall segment being at least partially displaceable. The massage device further includes a drive device for inducing a predetermined vibration in the end wall segment, with the first circumferential wall segment being substantially rigid and the second circumferential wall segment being substantially flexible.

Abstract: A massage device for massaging by means of pressure waves includes a housing having a handle segment and a massage segment and at least one chamber comprising an opening leading outward in the massage segment. The chamber includes an end wall segment, a first circumferential wall segment, and a second circumferential wall segment, the first circumferential wall segment being disposed between the end wall segment and the second circumferential wall segment, and the second circumferential wall segment defining the opening with the end wall segment being at least partially displaceable. The massage device further includes a drive device for inducing a predetermined vibration in the end wall segment, with the first circumferential wall segment being substantially rigid and the second circumferential wall segment being substantially flexible.

Abstract: The invention relates to a massage device (1) for massage by means of pressure waves, comprising a housing (2) having a grip section (4) and a massage section (6), at least one first chamber (8, 10) having an opening (12) in the massage section, leading towards the outside, and a drive means (30) for changing the volume (V1) of the first chamber (8), wherein the drive means (30) has at least one coil element (32, 34) and at least one movably guided magnetic core (38) arranged parallel to the coil element (32, 34) for acting on the first chamber (8).