Abstract: In a certain aspect, some embodiment provides apparatus and methods to facilitate the launching or throwing of streamer rolls, consisting of various paper, plastic and/or other materials, including in particular rolled paper or other material. Various embodiments provide such an apparatus that is safe and easy to use, durable, and/or economical to manufacture.

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I.

Abstract: The present invention relates to the use of compounds of general formula (I): (I) for the preparation of medicaments that act against mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as mitochondrial diseases.

Abstract: The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inhibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YY1, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN).

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: Disclosed are methods of treating infectious diseases comprising administering to an animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: The embodiments that are described herein provide random access to individual data storage locations of a group of buffers, which may be scattered in the memory. These embodiments provide a virtual memory interface that applies virtual addresses in a flat memory linear addressing space as indices into the physical memory addresses that are ordered into a sequence in accordance with the group of buffers. In this way, these embodiments enable a device (e.g., a processor) to directly and sequentially access all of the scattered physical memory locations of a fragmented data item, such as a packet, without having to perform any memory segmentation or paging processes. In some embodiments, these accesses include both read and write accesses to the scattered data storage locations.

Abstract: Disclosed are methods of treating cancer, inflammatory conditions, and/or infectious disease in an animal comprising: administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

Abstract: A block of contiguous data storage locations of a memory is divided into pools of memory chunks. The memory chunks in same ones of the pools have equal chunk sizes. The memory chunks in different ones of the pools have different chunk sizes. In each of the pools, the memory chunks are addressable by respective chunk base physical addresses in a respective linear contiguous sequence that starts from a respective pool base physical address. The physical addresses of the memory chunks are translated into corresponding internal handles and vice versa, where each of the internal handles is smaller in size than its corresponding physical address. For each of the pools, an associated pool queue comprising respective ones of the internal handles to allocatable ones of the memory chunks in the pool is maintained.

Abstract: Disclosed are methods of treating infectious diseases comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a human or a rodent.

Abstract: The present invention relates to methods and compositions for treating and evaluating metastatic conditions.

Abstract: The embodiments that are described herein provide random access to individual data storage locations of a group of buffers, which may be scattered in the memory. These embodiments provide a virtual memory interface that applies virtual addresses in a flat memory linear addressing space as indices into the physical memory addresses that are ordered into a sequence in accordance with the group of buffers. In this way, these embodiments enable a device (e.g., a processor) to directly and sequentially access all of the scattered physical memory locations of a fragmented data item, such as a packet, without having to perform any memory segmentation or paging processes. In some embodiments, these accesses include both read and write accesses to the scattered data storage locations.

Abstract: A block of contiguous data storage locations of a memory is divided into pools of memory chunks. The memory chunks in same ones of the pools have equal chunk sizes. The memory chunks in different ones of the pools have different chunk sizes. In each of the pools, the memory chunks are addressable by respective chunk base physical addresses in a respective linear contiguous sequence that starts from a respective pool base physical address. The physical addresses of the memory chunks are translated into corresponding internal handles and vice versa, where each of the internal handles is smaller in size than its corresponding physical address. For each of the pools, an associated pool queue comprising respective ones of the internal handles to allocatable ones of the memory chunks in the pool is maintained.

Abstract: Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.

Abstract: A wireless (such as Wi-Fi or similar) access point is included in or attached to a device, such as a cellular phone, WiMAX device, other mobile device, etc. One or more wireless units wirelessly access a communication network (and in some cases the Internet) through the wireless access point device. Additionally, such a wireless access point device can receive a transmission from a wireless tag that has been attached to an object to be monitored and can forward information from the wireless tag to a target device along with location information.

Abstract: Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.