Patents by Inventor Michael Parnham

Michael Parnham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • B7-H1 fusion polypeptides for treating and preventing organ failure
    Patent number: 11679142
    Abstract: The present invention pertains to a fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis, said fusion polypeptide comprises at least (i) a first portion being a Fc portion of an immunoglobulin and (ii) a second portion comprising the extracellular portion of the human B7-H1 polypeptide or a variant thereof. Moreover, also encompassed by the invention is a polynucleotide encoding said fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: June 20, 2023
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Andreas Von Knethen, Michael Parnham, Lisa Katharina Sha
  • COMBINATION THERAPY FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20220257755
    Abstract: The present invention pertains to compounds and their combination for use in the prevention or therapy of a subject suffering from an autoimmune disease such as diabetes type 1. Provided are antagonists of T-cells that are used in combination with antagonists of the cytokine CXCL10, sequentially or concomitantly, in a subject suffering from an autoimmune disease, in particular diabetes type 1.
    Type: Application
    Filed: December 27, 2021
    Publication date: August 18, 2022
    Inventors: URS CHRISTEN, STANLEY LASCH, MICHAEL PARNHAM
  • Composition comprising a biocompatible and biodegradable polymer, nanocarriers and a drug and methods of making and using the same
    Patent number: 10953103
    Abstract: The present invention pertains to a composition comprising at least one biocompatible and biodegradable polymer, the polymer further comprising nanocarriers wherein the nanocarriers comprise a drug. Moreover, also encompassed by the invention is the use of the composition in the treatment of a disease and a method for manufacturing the composition.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: March 23, 2021
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V
    Inventors: Matthias Wacker, Susanne Beyer, Michael Parnham, Werner Mäntele, Li Xie, Vitali Vogel
  • B7-H1 FUSION POLYPEPTIDES FOR TREATING AND PREVENTING ORGAN FAILURE
    Publication number: 20200215159
    Abstract: The present invention pertains to a fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis, said fusion polypeptide comprises at least (i) a first portion being a Fc portion of an immunoglobulin and (ii) a second portion comprising the extracellular portion of the human B7-H1 polypeptide or a variant thereof. Moreover, also encompassed by the invention is a polynucleotide encoding said fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis.
    Type: Application
    Filed: March 18, 2020
    Publication date: July 9, 2020
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Andreas VON KNETHEN, Michael PARNHAM, Lisa Katharina SHA
  • B7-H1 fusion polypeptides for treating and preventing organ failure
    Patent number: 10632174
    Abstract: The present invention pertains to a fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis, said fusion polypeptide comprises at least (i) a first portion being a Fc portion of an immunoglobulin and (ii) a second portion comprising the extracellular portion of the human B7-H1 polypeptide or a variant thereof. Moreover, also encompassed by the invention is a polynucleotide encoding said fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: April 28, 2020
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V
    Inventors: Andreas Von Knethen, Michael Parnham, Lisa Katharina Sha
  • COMBINATION THERAPY FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20190351056
    Abstract: The present invention pertains to compounds and their combination for use in the prevention or therapy of a subject suffering from an autoimmune disease such as diabetes type 1. Provided are antagonists of T-cells that are used in combination with antagonists of the cytokine CXCL10, sequentially or concomitantly, in a subject suffering from an autoimmune disease, in particular diabetes type 1.
    Type: Application
    Filed: August 2, 2019
    Publication date: November 21, 2019
    Inventors: URS CHRISTEN, STANLEY LASCH, MICHAEL PARNHAM
  • Combination therapy for the treatment of autoimmune diseases
    Patent number: 10413605
    Abstract: The present invention pertains to compounds and their combination for use in the prevention or therapy of a subject suffering from an autoimmune disease such as diabetes type 1. Provided are antagonists of T-cells that are used in combination with antagonists of the cytokine CXCL10, sequentially or concomitantly, in a subject suffering from an autoimmune disease, in particular diabetes type 1.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: September 17, 2019
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Urs Christen, Stanley Lasch, Michael Parnham
  • Composition Comprising a Biocompatible and Biodegradable Polymer, Nanocarriers and a Drug and Methods of Making and Using the Same
    Publication number: 20180318433
    Abstract: The present invention pertains to a composition comprising at least one biocompatible and biodegradable polymer, said polymer further comprising nanocarriers wherein said nanocarriers comprise a drug. Moreover, also encompassed by the invention is the use of said composition in the treatment of a disease and a method for manufacturing said composition.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Matthias WACKER, Susanne BEYER, Michael PARNHAM, Werner MÄNTELE, Li XIE, Vitali VOGEL
  • B7-H1 Fusion Polypeptides for Treating and Preventing Organ Failure
    Publication number: 20180243372
    Abstract: The present invention pertains to a fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis, said fusion polypeptide comprises at least (i) a first portion being a Fc portion of an immunoglobulin and (ii) a second portion comprising the extracellular portion of the human B7-H1 polypeptide or a variant thereof. Moreover, also encompassed by the invention is a polynucleotide encoding said fusion polypeptide for use in treating and/or preventing organ failure in a subject suffering from sepsis.
    Type: Application
    Filed: August 19, 2016
    Publication date: August 30, 2018
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Andreas VON KNETHEN, Michael PARNHAM, Lisa Katharina SHA
  • COMBINATION THERAPY FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20170021018
    Abstract: The present invention pertains to compounds and their combination for use in the prevention or therapy of a subject suffering from an autoimmune disease such as diabetes type 1. Provided are antagonists of T-cells that are used in combination with antagonists of the cytokine CXCL10, sequentially or concomitantly, in a subject suffering from an autoimmune disease, in particular diabetes type 1.
    Type: Application
    Filed: April 8, 2014
    Publication date: January 26, 2017
    Inventors: Urs CHRISTEN, Stanley LASCH, Michael PARNHAM
  • Novel therapeutic indication of azithromycin for treatment of non-infective inflamatory diseases
    Publication number: 20050054587
    Abstract: The invention relates to the use of 9-deoxo-9-dihydro-9a-methyl-9a-homoerythromycin. A (generic name: azithromycin) for the therapy of neutrophil-dominated non-infective inflammatory diseases, pharmaceutical compositions containing azithromycin for enteral or parenteral administration and methods for the production of these pharmaceutical compositions.
    Type: Application
    Filed: April 10, 2002
    Publication date: March 10, 2005
    Inventors: Ognjen Culic, Michael Parnham, Vesna Erakovic
  • Anti-inflammatory picolyselenobenzamides and salts thereof
    Patent number: 5126357
    Abstract: A compound or a pharmaceutically acceptable salt thereof, having anti-inflammatory activity, is disclosed according to the Formula (I) ##STR1## wherein R is hydrogen, methyl or ethyl,R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group or is phenyl, chlorophenyl or fluorophenyl,R.sub.2 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group,R.sub.3 and R.sub.4 are identical or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano or nitro or, taken together, are methylenedioxy, and n is 0 or 1.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: June 30, 1992
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Michel Evers, Michael Parnham, Axel Romer, Hartmut Fischer, Norbert Dereu
  • S-(carbamoyl-phenylselenyl) derivatives of glutathione and of aminomercaptocarboxylic acids
    Patent number: 4618669
    Abstract: The present invention relates to new S-(carbamoylphenylselenyl) derivatives of glutathione and of .alpha.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: October 21, 1986
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Norbert Dereu, Andre Welter, Albrecht Wendel, Sigurd Leyck, Michael Parnham, Erich Graf, Helmut Sies, Hans Betzing, Hartmut Fischer