Abstract: A computer-implemented method for maintaining or improving a user's state of wellbeing, the method comprising: collecting passive data from the user; identifying a cognitive marker within the data and determining a score for the identified marker; predicting the user's state of wellbeing by inputting the score into a statistical predictive model; and generating an output configured to maintain or improve the user's state of wellbeing, wherein the output is based on the user's predicted state of wellbeing.

Abstract: A delivery device for a collapsible prosthetic heart valve, the delivery device including an inner shaft, a distal sheath disposed about a portion of the inner shaft and forming a compartment with the inner shaft, the compartment being adapted to receive the prosthetic heart valve, the inner shaft and the distal sheath being movable relative to one another, and a handle including a frame having a longitudinal axis, a proximal end and a distal end, the handle further including a deployment actuator and a hub, each of the deployment actuator and the hub being independently capable of opening and closing the compartment, the hub further including a hub actuator coupled to the inner shaft.

Abstract: A scupper valve includes a frame and a rigid flapper coupled to the frame. The rigid flapper is configured to swing relative to the rigid frame between an open and closed position. A flexible annular seal defines a centrally-disposed circular opening and a first annular projection that surrounds the centrally-disposed opening. The rigid flapper, in the closed position, contacts a distal edge of the first annular projection to create a circular line contact that restricts or prevents fluid flow through the centrally-disposed circular opening in the flexible annular seal. A rigid annular backplate is adjacent to and in direct physical contact with an annular surface of the flexible seal on a side of the flexible seal opposite the rigid flapper.

Abstract: A scupper valve includes a frame and a rigid flapper coupled to the frame. The rigid flapper is configured to swing relative to the rigid frame between an open and closed position. A flexible annular seal defines a centrally-disposed circular opening and a first annular projection that surrounds the centrally-disposed opening. The rigid flapper, in the closed position, contacts a distal edge of the first annular projection to create a circular line contact that restricts or prevents fluid flow through the centrally-disposed circular opening in the flexible annular seal. A rigid annular backplate is adjacent to and in direct physical contact with an annular surface of the flexible seal on a side of the flexible seal opposite the rigid flapper.