Abstract: A highly effective synthetic route to produce donor-acceptor azetines through the highly enantioselective [3+1]-cycloaddition of silyl-protected enoldiazoacetates with aza-ylides using chiral copper(I) catalysis is provided. In one embodiment, the 2-azetidine cycloaddition products undergo generation of 3-azetidinones by reactions with nucleophiles that produce a broad spectrum of peptide products by the retro-Claisen reaction provided by facile strain with high efficacy and complete retention of enantiopurity. This ring opening reaction uncovers a new methodology for the attachment of chiral peptide units to a variety of amines and alcohols, and tolerates a broad scope of nucleophiles including naturally occurring amines, alcohols, amino acids, and other nitrogen based nucleophiles.

Abstract: A highly effective synthetic route to produce donor-acceptor azetines through the highly enantioselective [3+1]-cycloaddition of silyl-protected enoldiazoacetates with aza-ylides using chiral copper(I) catalysis is provided. In one embodiment, the 2-azetidine cycloaddition products undergo generation of 3-azetidinones by reactions with nucleophiles that produce a broad spectrum of peptide products by the retro-Claisen reaction provided by facile strain with high efficacy and complete retention of enantiopurity. This ring opening reaction uncovers a new methodology for the attachment of chiral peptide units to a variety of amines and alcohols, and tolerates a broad scope of nucleophiles including naturally occurring amines, alcohols, amino acids, and other nitrogen based nucleophiles.

Abstract: A system and method for dynamic generation of procedures is disclosed. The method comprises: (a) storing asset types defining attributes; asset instances, inheriting attributes of one of the asset types and having attribute-values; procedure statements being associated to conditional rule(s) to be applied to an attribute-value of an asset instance; and procedure templates, each defining a unique combination of asset type and a group of said procedure statements. The method further comprises (b) for a given asset instance and a given procedure template: (i) iteratively reading each of the procedure statements of the group of procedure statements being associated to the given procedure template; and (ii) presenting, on a user interface, each one of the procedure statements where a condition is met when the corresponding conditional rule(s) is applied to the attribute-values of the given asset instance, in order to dynamically generate an asset specific procedure.

Abstract: A system and method for dynamic generation of procedures is disclosed. The method comprises: (a) storing asset types defining attributes; asset instances, inheriting attributes of one of the asset types and having attribute-values; procedure statements being associated to conditional rule(s) to be applied to an attribute-value of an asset instance; and procedure templates, each defining a unique combination of asset type and a group of said procedure statements. The method further comprises (b) for a given asset instance and a given procedure template: (i) iteratively reading each of the procedure statements of the group of procedure statements being associated to the given procedure template; and (ii) presenting, on a user interface, each one of the procedure statements where a condition is met when the corresponding conditional rule(s) is applied to the attribute-values of the given asset instance, in order to dynamically generate an asset specific procedure.

Abstract: The present disclosure encompasses compositions comprising a surfactant, and an acid such as, but not limited to, levulinic acid, that together have a synergistic effect in reducing the viability of a virus population compared to the efficacy of the individual compounds. This synergy allows the formulation of compositions where the active agents (including an acid and a surfactant) are present at concentrations effective to inactivate viruses on surfaces, including human skin. The viricidal compositions disclosed herein are efficacious without damaging the surface to which they may be applied, or even altering the organoleptic properties of a treated food substance. The viricidal compositions and wipes containing such compositions are suitable for sanitizing any surface suspected of having a viral load thereon, or where it is desirable to ensure that a viral load is as low as possible.

Abstract: Antimicrobial compositions are provided comprising a pharmaceutically acceptable organic acid and a pharmaceutically acceptable surfactant. This synergistic combination allows compositions to be formulated at low concentrations that have efficacy in reducing bacterial counts by greater than 3 log within 5 minutes of contact while preserving the organoleptic properties of treated foods, including fresh produce. As shown in FIG. 1C the efficacy of six different compositions (A. 3% levulinic acid plus 2% SDS; B. 2% levulinic acid plus 1% SDS; C. 0.5% levulinic acid plus 0.05% SDS; D. 3% levulinic acid; E. 2% SDS and F. water) were tested for their ability to kill spores of Bacillus anthracis Sterne after 45 minutes of contact.

Abstract: A method for increasing the rate of thermal inactivation of a pathogen in a nutriment by contacting the nutriment with an acidulant. A method for extending case shelf-life of a nutriment by contacting the nutriment with an acidulant. The acidulant can be: (a) an acidic, or low pH, solution of sparingly-soluble Group IIA complexes (“AGIIS”); (b) a highly acidic metalated mixture of inorganic acid (“HAMMIA”); (c) a highly acidic metalated organic acid (“HAMO”); (d) a mixture of the above; or (e) an adduct of each of the above. The nutriment can be an animal product, a plant product, a beverage, or a mixture thereof.