Patents by Inventor Michael Paul Fleming

Michael Paul Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR ISOLATING THERAPEUTIC PEPTIDES
    Publication number: 20100261877
    Abstract: Disclosed are methods of isolating linaclotide, a cyclized 14-amino-acid peptide with three disulfide bonds. The sequence consists of Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr with disulfide bridges between the cysteine residues at positions 1 and 6, 2 and 10, and 5 and 13. The drug acts as a GCC superagonist, elevating intracellular cGMP composition for treating various disorders, including gastrointestinal disorders, obesity, congestive heart failure and benign prostatic hyperplasia.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 14, 2010
    Inventors: Michael Paul Fleming, Raymond Dennis Petersen