Patents by Inventor Michael Paulista

Michael Paulista has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Growth/differentiation factor of the TGF-? family
    Patent number: 7642237
    Abstract: The invention concerns a protein of the TGF-? family, the DNA coding therefor and a pharmaceutical composition containing the protein.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: January 5, 2010
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hoetten, Helge Neidhardt, Michael Paulista
  • Use of MP52 or MP121 for the treatment and prevention of diseases of the nervous system
    Patent number: 7632808
    Abstract: The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: December 15, 2009
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka
    Inventors: Gertrud Hötten, Jens Pohl, Rolf Bechtold, Michael Paulista, Klaus Unsicker
  • Use of cytokines of the TGF-? superfamily for the treatment, inhibition and/or diagnosis of skin related disorders
    Patent number: 7479279
    Abstract: The present invention relates to the use of cytokines of the TGF-?-superfamily as well as nucleic acids encoding said cytokines for the treatment and diagnosis of skin related disorders, including hair and gland related disorders in mammals.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: January 20, 2009
    Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka
    Inventors: Michael Paulista, Jens Pohl
  • Compounds with improved cartilage-inducing and/or bone-inducing activity
    Patent number: 7365051
    Abstract: The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-? superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: April 29, 2008
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Michael Paulista, Jens Pohl, Joachim Pabst, Helmut Heide
  • Antibodies to a growth/differentiation factor of the TGF-? family
    Patent number: 7129054
    Abstract: The invention relates to an antibody or antibody fragment which specifically binds to a protein of the TGF-? family. The invention also relates to a kit for detecting a protein of the TGF-? family which comprises the antibody or antibody fragment. Finally, the invention relates to method for detecting a protein of the TGF-? family which uses the antibody or antibody fragment.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: October 31, 2006
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hötten, Helge Neidhardt, Rolf Bechtold, Jens Pohl, Michael Paulista
  • MP121, a growth/differentiation factor of the TGF-? family
    Patent number: 7025959
    Abstract: The invention concerns a protein of the TGF-? family, the DNA coding therefor and a pharmaceutical composition containing such protein.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: April 11, 2006
    Assignee: Biopharm Gesellschaft Zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hötten, Helge Neidhardt, Rolf Bechtold, Jens Pohl, Michael Paulista
  • Growth/differentiation factor of the TGF-beta family
    Publication number: 20050220794
    Abstract: The invention relates to an antibody or antibody fragment which specifically binds to a protein of the TGF-? family. The invention also relates to a kit for detecting a protein of the TGF-? family which comprises the antibody or antibody fragment. Finally, the invention relates to method for detecting a protein of the TGF-? family which uses the antibody or antibody fragment.
    Type: Application
    Filed: May 19, 2005
    Publication date: October 6, 2005
    Applicant: Biopharm Gesellschaft zur
    Inventors: Gertrud Hotten, Helge Neidhardt, Rolf Bechtold, Jens Pohl, Michael Paulista
  • Compounds with improved cartilage-inducing and/or bone-inducing activity
    Publication number: 20050169965
    Abstract: The present invention concerns a bioactive implant material having a cartilage-inducing and/or bone-inducing activity composed of two components A and B, of which A is a bone-inducing and/or cartilage-inducing protein or protein mixture and preferably one or several proteins from the TGF-? superfamily, preferably MP52 or a DNA sequence coding therefor and B is a carrier matrix composed of calcium phosphate ceramics with an interconnecting microporosity which already alone has bone-inducing properties. The invention additionally concerns the production of these compounds and their use for the treatment of diseases which affect cartilage and/or bones as well as to treat damage to cartilage and/or bone tissue.
    Type: Application
    Filed: March 16, 2005
    Publication date: August 4, 2005
    Applicant: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Michael Paulista, Jens Pohl, Joachim Pabst, Helmut Heide
  • Cytokines having neurotrophic activity
    Patent number: 6790824
    Abstract: The present invention relates to a pharmaceutical composition having neurotrophic activity, comprising a biologically active amount of at least two cytokines, wherein at least one of said cytokines is BMP, GDF, TGF-&bgr; or GDNF.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 14, 2004
    Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Klaus Unsicker, Jens Pohl, Michael Paulista, Rolf Bechtold
  • Growth/differentiation factor of the TGF-beta family
    Publication number: 20040146979
    Abstract: The invention concerns a protein of the TGF-&bgr; family, the DNA coding therefor and a pharmaceutical composition containing the protein.
    Type: Application
    Filed: March 16, 2004
    Publication date: July 29, 2004
    Applicant: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hotten, Helge Neidhardt, Michael Paulista
  • Growth/differential factor of the TGF-B family
    Patent number: 6764994
    Abstract: The invention concerns a protein of the TGF-&bgr; family, the DNA coding therefor and a pharmaceutical composition containing the protein.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: July 20, 2004
    Assignee: Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hötten, Helge Neidhardt, Michael Paulista
  • Use of cytokines of the tgg-beta superfamily for the treatment and diagnosis of skin related disorders
    Publication number: 20040097456
    Abstract: The present invention relates to the use of cytokines of the TGF-&bgr;-superfamily as well as nucleic acids encoding said cytokines for the treatment and diagnosis of skin related disorders, including hair and gland related disorders in mammals.
    Type: Application
    Filed: September 23, 2003
    Publication date: May 20, 2004
    Inventors: Michael Paulista, Jens Pohl
  • Use of MP52 or MP121 for the treatment and prevention of diseases of the nervous system
    Publication number: 20030220248
    Abstract: The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.
    Type: Application
    Filed: February 3, 2003
    Publication date: November 27, 2003
    Inventors: Gertrud Hotten, Jens Pohl, Rolf Bechtold, Michael Paulista, Klaus Unsicker
  • Use of GDNF for treating corneal defects
    Publication number: 20030166537
    Abstract: The present invention relates to the use of a glial cell line-derived growth factor (GDNF) or a functionally active derivative or part thereof and/or an agonist which substitutes the functional activity of GDNF, and/or a nucleic acid containing at least a nucleotide sequence encoding the primary amino acid sequence of GDNF or the functionally active derivative or part thereof and/or of the agonist for the manufacture of a pharmaceutical composition for epidermal and stromal wound healing.
    Type: Application
    Filed: April 24, 2002
    Publication date: September 4, 2003
    Applicant: Biopharm Gesellschaft Zur Biotechnologischen Entwicklung von Pharmaka MBH
    Inventors: Michael Hanke, Friedrich Kruse, Michael Paulista, Jens Pohl
  • Use of MP52 or MP121 for treating and preventing diseases of the nervous system
    Patent number: 6531450
    Abstract: The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: March 11, 2003
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka
    Inventors: Gertrud Hötten, Jens Pohl, Rolf Bechtold, Michael Paulista, Klaus Unsicker
  • USE OF MP52 0R MP121 FOR TREATING AND PREVENTING DISEASES OF THE NERVOUS SYSTEM
    Publication number: 20020045568
    Abstract: The present invention concerns the use of biologically active MP52 or/and MP121 for the treatment and prevention of diseases of the nervous system or/and for the treatment of neuropathological situations which are caused by ageing of the nervous system. A pharmaceutical agent according to the invention for the treatment and prevention of diseases of the nervous system or/and for treating neuropathological situations which are caused by ageing of the nervous system therefore contains biologically active MP52 or/and MP121 as the active substance.
    Type: Application
    Filed: May 18, 1998
    Publication date: April 18, 2002
    Inventors: GERTRUD HOTTEN, JENS POHL, ROLF BECHTOLD, MICHAEL PAULISTA, KLAUS UNSICKER
  • Method of treatment with growth/differentiation factors of the TGF-&bgr; family
    Patent number: 6171584
    Abstract: The invention concerns a protein of the TGF-&bgr; family, the DNA coding therefor and a pharmaceutical composition containing such protein.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: January 9, 2001
    Assignee: Biopharm Gesellschaft zur Biotechnologischen Entwicklung von Pharmaka mbH
    Inventors: Gertrud Hötten, Helge Neidhardt, Rolf Bechtold, Jens Pohl, Michael Paulista
  • Growth/differentiation factor of the TGF-.beta. family
    Patent number: 5994094
    Abstract: The invention concerns a protein of the TGF-.beta. family, the DNA coding therefor and a pharmaceutical composition containing the protein.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: November 30, 1999
    Assignee: Biopharm Gesellschaft Zur Biotechnologischen
    Inventors: Gertrud Hotten, Helge Neidhardt, Michael Paulista