Abstract: Methods and systems provided herein address current limitations of bisulfite-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: Methods and systems provided herein address current limitations of bisulfite-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: Methods and systems provided herein address current limitations of bisulfite-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: The present disclosure provides methods and systems for preparing and using contrived nucleic acid samples for process validation and control. The contrived nucleic acid samples have prescribed specific physical and chemical characteristics, and are present in quantities sufficient to validate and confirm large-scale sequencing processes. Method validation may require known samples to confirm expected outcomes of the processes being validated. The inherent biological variability of biological samples obtained from individuals may not be suitable for the rigid requirements of process validation. The contrived biological samples described herein may approximate the complexity and biological features of a biological sample in a known and defined manner that may be controlled accordingly for the processes being validated.

Abstract: Systems, devices and methods to measure a haze value of a lens using a light proof box housing a stand, a light source and a camera. The stand has an orientation to position the lens to be flat, adjacent to the light source, and have the lens edge facing the light source. The light source is configured to emit a blue light into a lens edge of the lens. The camera is oriented to face a top surface of the lens, the camera is configured to measure blue light emitted from the top surface of the lens. A computing device coupled with the camera is configured to calculate the haze value of the lens based on the measured blue light.

Abstract: Methods and systems provided herein address current limitations of bisulfite-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: Provided herein is a method for determination of the frequency of a genetic rearrangement within the combined DNA from a population, and for determination of the fraction or amount of any physical or chemical property correlated with a genetic rearrangement in a population.

Abstract: Methods and systems provided herein address current limitations of bisulfate-based methylation sequencing by improving the quality and accuracy of nucleic acid methylation sequencing and uses thereof for detection of disease. Methods that include minimally-destructive conversion methods for methylation sequencing as well as specialized UMI adapters provide for improved quality of sequencing libraries and sequencing information. Greater accuracy and more complete methylation-state information permits higher quality feature generation for use in machine learning models and classifier generation.

Abstract: A phone comprising: a phone body, at least one sensor on the phone body for measuring a vital sign of a user when the phone is held in use; means for converting the vital sign measurement into a voice-frequency band signal; and means for transmitting the voice-frequency band signal for use in monitoring the health of the user.

Abstract: A phone comprising: a phone body, at least one sensor on the phone body for measuring a vital sign of a user when the phone is held in use; means for converting the vital sign measurement into a voice-frequency band signal; and means for transmitting the voice-frequency band signal for use in monitoring the health of the user.

Abstract: A pinch bar for a pinch valve is comprised of a coil spring coupled to one end of an actuating rod. An opposite end of the rod is formed with, or is coupled to a device or surface, which applies a pinch force. The actuating rod slides through a fixed-in-place rod actuator. The rod actuator, spring and actuating rod thus provide a mechanism that applies a closing force inwardly, into or directed toward a cabinet attached to which is a valve body for the pinch bar and against which the pinch bar could exert a tube-closing force.

Abstract: A pinch bar for a pinch valve is comprised of a coil spring coupled to one end of an actuating rod. An opposite end of the rod is formed with, or is coupled to a device or surface, which applies a pinch force. The actuating rod slides through a fixed-in-place rod actuator. The rod actuator, spring and actuating rod thus provide a mechanism that applies a closing force inwardly, into or directed toward a cabinet attached to which is a valve body for the pinch bar and against which the pinch bar could exert a tube-closing force.

Abstract: The invention disclosed is directed to a method and apparatus which allows a “rolling shutter” type of read out sequence in a pixel array that is read using a double sampling technique by having the rows of pixels reset a second time in each of their cycles for a second sampling while the rows are being accessed for reading. In this way, each pixel is sampled to compare its voltage level after integration to its voltage level as it is reset. In accordance with the present invention, the row access signal or a signal that is used to generate the row access signal, is used to generate a second reset signal at the correct time while the row is being accessed. The invention is particularly applicable to image sensors having light sensitive elements that are CMOS pixels, and in particular three transistor pixels.

Abstract: The present invention implements an automated blank time function, which calculates a horizontal and/or a vertical blank time for a desired integration time and window size. Input data and control signals for predetermined integration time and window size are provided to a register interface, which generates configuration signals. The configuration signals are applied to machines, which generate reset control signals and read control signals from the configuration signals for controlling the imager.

Abstract: An athletic game ball purse having the look and feel of a game ball and a method of making the athletic game ball purse with the athletic game ball purse comprising an athletic game ball shell having an interior compartment, a pouch housing located within the interior compartment of the game ball shell for receiving articles to be carried therein, an elongated aperture located on and extending across the game ball shell to allow a user to place the user's hand through the elongated aperture and into the pouch housing, a tape for supporting the pouch housing in the interior compartment of the game ball shell, a fastener located on the tape for moving the game ball shell between an open condition and a closed condition, and at least one holding strap secured to the athletic game ball shell for facilitating the handling of the game ball shell as a purse.

Abstract: The invention disclosed is directed to a method and apparatus which allows a “rolling shutter” type of read out sequence in a pixel array that is read using a double sampling technique by having the rows of pixels reset a second time in each of their cycles for a second sampling while the rows are being accessed for reading. In this way, each pixel is sampled to compare its voltage level after integration to its voltage level as it is reset. In accordance with the present invention, the row access signal or a signal that is used to generate the row access signal, is used to generate a second reset signal at the correct time while the row is being accessed. The invention is particularly applicable to image sensors having light sensitive elements that are CMOS pixels, and in particular three transistor pixels.