Patents by Inventor Michael Pesachovich

Michael Pesachovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated valacyclovir impurity, process for the preparation of valacyclovir impurity and use as a reference standard
    Patent number: 7629461
    Abstract: The present invention provides an isolated N-formyl valacyclovir, its preparation and its use as a reference marker and/or reference standard.
    Type: Grant
    Filed: September 6, 2005
    Date of Patent: December 8, 2009
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Amihai Eisenstadt, Michael Pesachovich
  • Methods of stabilizing azithromycin
    Publication number: 20080149521
    Abstract: A method of packaging of azithromycin which provides improved stability of azithromycin upon storage. Additionally, compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Application
    Filed: September 13, 2006
    Publication date: June 26, 2008
    Inventors: Michael Pesachovich, Sarah Isaacs, Claude Singer, Eduard Schwartz, Edit Berger, Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan
  • Methods of stabilizing azithromycin
    Publication number: 20070199856
    Abstract: A method of packaging of azithromycin which provides improved stability of azithromycin upon storage. Additionally, compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Application
    Filed: September 14, 2006
    Publication date: August 30, 2007
    Inventors: Michael Pesachovich, Sarah Isaacs, Claude Singer, Eduard Schwartz, Edit Berger, Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan
  • Stable micronized candesartan cilexetil and methods for preparing thereof
    Publication number: 20070082055
    Abstract: The invention encompasses sable candesartan cilexetil of fine particle size, wherein desethyl-candesartan (desethyl-CNS) within the stable candesartan cilexetil does not increase to more than about 0.1% w/w by HPLC relative to the initial amount of candesartan cilexetil, when the stable candesartan cilexetil is maintained at a temperature of about 55° C. for at least 2 weeks, methods of making the same and pharmaceutical compositions thereof.
    Type: Application
    Filed: May 10, 2006
    Publication date: April 12, 2007
    Inventors: Ziv Kurgan, Michael Pesachovich
  • Hydrogenation of precursors to thiazolidinedione antihyperglycemics
    Publication number: 20060252803
    Abstract: Provided is pioglitazone having a low level of impurities, especially a low level of the precursor PIE. Also provided is a method for making pioglitazone having a low level of impurities.
    Type: Application
    Filed: January 26, 2006
    Publication date: November 9, 2006
    Inventors: Ben-Zion Dolitzky, Michael Pesachovich
  • Stable gabapentin having pH within a controlled range
    Publication number: 20060122271
    Abstract: A pharmaceutical composition containing substantially pure and stable gabapentin are disclosed wherein gabapentin has a pH of between 6.8 to 7.3.
    Type: Application
    Filed: January 20, 2006
    Publication date: June 8, 2006
    Inventors: Claude Singer, Gideon Pilarski, Michael Pesachovich, Eduard Schwartz
  • Isolated valacyclovir impurity, process for the preparation of valacyclovir impurity and use as a reference standard
    Publication number: 20060084668
    Abstract: The present invention provides an isolated N-formyl valacyclovir, its preaparation and its use as a reference marker and/or reference standard.
    Type: Application
    Filed: September 6, 2005
    Publication date: April 20, 2006
    Inventors: Amihai Eisenstadt, Michael Pesachovich
  • Process for the preparation of valacyclovir hydrochloride
    Publication number: 20050192296
    Abstract: Provided are HPLC methods for analyzing BOC-L-alanine in BOC-L-valine and alanine analogues in valacyclovir hydrochloride and a use and method of selecting valacyclovir compositions.
    Type: Application
    Filed: January 21, 2005
    Publication date: September 1, 2005
    Inventors: Zvi Harel, Michael Pesachovich
  • Stabilized azithromycin compositions
    Publication number: 20050106239
    Abstract: Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Application
    Filed: September 7, 2004
    Publication date: May 19, 2005
    Inventors: Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan, Claude Singer, Michael Pesachovich
  • Degradation products of azithromycin, and methods for their indentification
    Publication number: 20040266997
    Abstract: The invention is directed to degradation products of azithromycin, methods for the preparation and identification of the degradation products which may be produced during storage and/or synthesis of azithromycin.
    Type: Application
    Filed: March 25, 2004
    Publication date: December 30, 2004
    Inventors: Michael Pesachovich, Sarah Isaacs, Claude Singer, Eduard Schwartz, Edit Berger
  • Method of stabilizing azithromycin
    Publication number: 20040226852
    Abstract: A method of packaging of azithromycin which provides improved stability of azithromycin upon storage.
    Type: Application
    Filed: February 19, 2004
    Publication date: November 18, 2004
    Inventors: Michael Pesachovich, Sarah Isaacs, Claude Singer, Eduard Schwartz, Edit Berger
  • Stabilized azithromycin compositions
    Publication number: 20040192622
    Abstract: Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Application
    Filed: April 13, 2004
    Publication date: September 30, 2004
    Inventors: Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan, Claude Singer, Michael Pesachovich
  • Stable gabapentin having pH within a controlled range
    Publication number: 20040147607
    Abstract: A pharmaceutical composition containing substantially pure and stable gabapentin are disclosed wherein gabapentin has a pH of between 6.8 to 7.3.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 29, 2004
    Inventors: Claude Singer, Gideon Pilarski, Michael Pesachovich, Eduard Schwartz
  • Stabilized azithromycin compositions
    Patent number: 6764997
    Abstract: Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: July 20, 2004
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan, Claude Singer, Michael Pesachovich
  • Stabilized azithromycin compositions
    Publication number: 20030176369
    Abstract: Compositions and methods of stabilizing azithromycin compositions are described. Stabilized azithromycin compositions comprise an intimate admixture of azithromycin and a stabilizing-effective amount of an antioxidant to improve the resistance of the azithromycin to degradation. Coprecipitation or co-milling of azithromycin and an antioxidant are particularly preferred means of achieving an intimate admixture. Pharmaceutical formulations comprising a stabilized azithromycin composition and methods of making such formulations are also described.
    Type: Application
    Filed: October 18, 2002
    Publication date: September 18, 2003
    Inventors: Ruth Tenengauzer, Joseph Schwarz, Julia Hrakovsky, Tania Lessen, Lev Khondo, Mathi Mathivanan, Claude Singer, Michael Pesachovich
  • Preparation method of azithromycin hydrates
    Patent number: 6586576
    Abstract: This invention relates to a method for preparing azithromycin dihydrate from crude azithromycin by the gradual crystallization of azithromycin from acetone by the addition of a minimal amount of water to effect crystal formation is disclosed. This invention also relates to a method of making azithromycin from desmethyl-azithromycin by dissolving desmethyl-azithromycin in acetone, adding activated carbon, adding formaldehyde, adding formic acid; refluxing the desmethyl-azithromycin acetone solution, adding sodium hydroxide to induce precipitation of azithromycin, and isolating azithromycin.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: July 1, 2003
    Assignee: Teva Pharmaceutical Industries LTD
    Inventors: Judith Aronhime, Claude Singer, Michael Pesachovich
  • Stable gabapentin having pH within a controlled range
    Publication number: 20030055109
    Abstract: A pharmaceutical composition containing substantially pure and stable gabapentin are disclosed wherein gabapentin has a pH of between 6.8 to 7.3.
    Type: Application
    Filed: August 26, 2002
    Publication date: March 20, 2003
    Inventors: Claude Singer, Gideon Pilarski, Michael Pesachovich
  • Stable gabapentin containing more than 20 ppm of chlorine ion
    Patent number: 6531509
    Abstract: Pharmaceutical compositions containing substantially pure and stable gabapentin are disclosed wherein gabapentin contains an anion of a mineral acid, such as chloride, in amounts greater than 20 ppm.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: March 11, 2003
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Claude Singer, Gideon Pilarski, Michael Pesachovich, Edward Schwartz
  • Stable gabapentin containing more than 20 ppm of chlorine ion
    Publication number: 20020061931
    Abstract: Pharmaceutical compositions containing substantially pure and stable gabapentin are disclosed wherein gabapentin contains an anion of a mineral acid, such as chloride, in amounts greater than 20 ppm.
    Type: Application
    Filed: June 15, 2001
    Publication date: May 23, 2002
    Inventors: Claude Singer, Gideon Pilarsky, Michael Pesachovich
  • Stable gabapentin having pH within a controlled range
    Publication number: 20020045662
    Abstract: A pharmaceutical composition containing substantially pure and stable gabapentin are disclosed wherein gabapentin has a pH of between 6.8 to 7.3.
    Type: Application
    Filed: June 15, 2001
    Publication date: April 18, 2002
    Inventors: Claude Singer, Gideon Pilarski, Michael Pesachovich