Patents by Inventor Michael Pfeil

Michael Pfeil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8489270
    Abstract: The invention relates to a method and corresponding device for diagnosing the dynamics of an exhaust gas sensor, which is disposed in an exhaust gas duct of an internal combustion engine in the direction of flow of the exhaust gas upstream or downstream of a catalytic converter and with which the air/fuel ratio of the gas mixture supplied to the internal combustion engine is controlled via a control circuit. During diagnosis, provision is made for at least one actuator intervention to be specified by means of a control algorithm of a diagnostic controller specifically m the direction of an asymmetric behavior, which is achieved by an extension of one of the two ramps, until the actuator intervention is compensated by an asymmetric dynamic error of the exhaust gas sensor, a reaction to said actuator intervention being used as criterion for assessing an asymmetric dynamic error of said exhaust gas sensor.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: July 16, 2013
    Assignee: Robert Bosch GmbH
    Inventors: Kersten Wehmeier, Michael Pfeil, Siyun Chu, Albrecht Clement
  • Publication number: 20120142024
    Abstract: The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed (active) neurotoxin polypeptides in a solution comprising processed neurotoxin polypeptides and partially processed or unprocessed neurotoxin polypeptides. The present invention further relates to a device for determining the amount of neurotoxin polypeptides and a kit adapted to carry out the method of the present invention.
    Type: Application
    Filed: April 23, 2010
    Publication date: June 7, 2012
    Inventors: Michael Pfeil, Josef Friedrich
  • Publication number: 20120130372
    Abstract: The medial compartment is realigned by adjusting the angle of the ulna so that the head end thereof is properly aligned with the humerus. The angle of the ulna is adjusted by cutting the ulna below the head. A plate is attached to the ulna to set the new angle. The plate has two parts; one part is straight, the other is angled. Different plates have parts with different angles. A plate with a desired angle is selected to achieve the necessary angle on the ulna. The plate may be attached to the medial side or lateral side of the ulna.
    Type: Application
    Filed: April 18, 2010
    Publication date: May 24, 2012
    Applicant: KYON PHARMA, INC
    Inventor: Ingo Michael Pfeil
  • Publication number: 20120004179
    Abstract: The present invention relates to an antibody which specifically binds to unprocessed and/or partially processed neurotoxin polypeptide or an antibody which specifically binds an epitope consisting of a peptide having an amino acid sequence as shown in any one of SEQ ID NOs: 1 to 16 and to methods for the manufacture of such antibodies. Moreover, the present invention relates to a composition comprising processed neurotoxin polypeptide free of unprocessed or partially processed neurotoxin polypeptide and a method for manufacturing said neurotoxin polypeptide based on the antibodies of the invention. The present invention also relates to the use of the aforementioned antibody for separating processed neurotoxin polypeptides from unprocessed or partially processed neurotoxin polypeptides or for determining unprocessed or partially processed neurotoxin polypeptides. The present invention relates to a method for the manufacture of a medicament.
    Type: Application
    Filed: February 17, 2010
    Publication date: January 5, 2012
    Applicant: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Michael Pfeil, Josef Friedrich, Harold Victor Taylor, Karl-Heinz Eisele, Cornelia Brunn
  • Publication number: 20110314892
    Abstract: A method for the dynamic monitoring of a first lambda probe arranged in an exhaust-gas duct of an internal combustion engine upstream of an exhaust-gas purification system. A period of an output signal of the first lambda probe is determined in a controller of the internal combustion engine, and a lambda regulating signal is determined from an output signal of a second lambda probe connected downstream of the exhaust-gas purification system. A first threshold value for a lengthening of the period of the output signal of the first lambda probe is predefined, in that a characteristic signal (46) is derived from the lambda regulating signal, in that a second threshold value for an inadmissible deviation of the characteristic signal (46) is predefined, and in that an inadmissible asymmetric delay of the first lambda probe is inferred if the lengthening of the period exceeds the first threshold value and the characteristic signal (46) deviates from the second threshold value outside predetermined limits.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Applicant: ROBERT BOSCH GMBH
    Inventors: Kersten Wehmeier, Michael Pfeil, Siyun Chu, Albrecht Clement
  • Patent number: 7954361
    Abstract: Method and apparatus for detecting tank leaks, in which a gas pressure acts on a fluid which is situated in a tank, and in which the gas pressure in the tank or tank system is changed, wherein a tank leak is detected by evaluation of a temporal profile of a sum pressure of the fluid which is situated in the tank.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: June 7, 2011
    Assignee: Robert Bosch GmbH
    Inventors: Peter Schelhas, Manfred Franz, Andreas Posselt, Andreas Baumann, Martin Streib, Michael Pfeil, Marko Lorenz, Silke Haag
  • Patent number: 7927836
    Abstract: The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is located within a working chamber or is adjacent to it. A pressure gradient in relation to ambient pressure prevails in both the insulator and in the working chamber.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: April 19, 2011
    Assignee: Merz Pharma GmbH & Co. KGaA
    Inventors: Bernd Doelle, Michael Pfeil
  • Publication number: 20110082622
    Abstract: The invention relates to a method for diagnosing the dynamics of an exhaust gas sensor embodied as a lambda probe, which is disposed in an exhaust gas duct of an internal combustion engine in the direction of flow of the exhaust gas upstream or downstream of a catalytic converter and with which the air/fuel ratio of the gas mixture supplied to the internal combustion engine is controlled via a control circuit. During the diagnosis, provision is made in the method according to the invention for at least one actuator intervention to be specified by means of a control algorithm of a diagnostic controller specifically in the direction of an asymmetric behavior, which is achieved by an extension of one of the two ramps, until the actuator intervention is compensated by a possible asymmetric dynamic error of the exhaust gas sensor, a reaction to said actuator intervention being used as the criterion for assessing an asymmetric dynamic error of said exhaust gas sensor.
    Type: Application
    Filed: September 28, 2010
    Publication date: April 7, 2011
    Applicant: Robert Bosch GMBH
    Inventors: Kersten Wehmeier, Michael Pfeil, Siyun Chu, Albrecht Clement
  • Patent number: 7584651
    Abstract: A method of diagnosing a fuel tank leak in a fuel tank ventilation system, comprising a fuel tank, an accumulator for fuel vapors and a fuel tank ventilation valve opening out into an intake manifold of an internal combustion engine, wherein the fuel tank, the accumulator and the fuel tank ventilation valve are connected by way of a system of lines and wherein the accumulator has an aeration line with a check valve, the method comprising: immediately before turning off the internal combustion engine, closing the check valve and opening the fuel tank ventilation valve to generate a vacuum in the fuel tank ventilation system; acquiring a vacuum degradation at specifiable points in time when the fuel tank ventilation valve is closed; opening of the check valve in order to bring about a pressure equilibrium with the ambient pressure; renewed closing of the check valve; acquiring a pressure increase emerging over at least a specifiable time interval and determination of a compensation variable; and inference ab
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: September 8, 2009
    Assignee: Robert Bosch GmbH
    Inventors: Martin Streib, Karl-Bernhard Lederle, Michael Pfeil
  • Publication number: 20090211560
    Abstract: The invention relates to a method for operating a tank system, in particularly of a motor vehicle, comprising a tank. According to the invention, said tank system has an adsorption filter for capturing the volatile substances exiting the tank. The loading of the adsorption filter suggests that the tank is being filled.
    Type: Application
    Filed: August 4, 2006
    Publication date: August 27, 2009
    Applicant: ROBERT BOSCH GMBH
    Inventors: Karl-Bernhard Lederle, Michael Pfeil, Silke Haag
  • Publication number: 20080196482
    Abstract: Method and apparatus for detecting tank leaks, in which a gas pressure acts on a fluid which is situated in a tank, and in which the gas pressure in the tank or tank system is changed, wherein a tank leak is detected by evaluation of a temporal profile of a sum pressure of the fluid which is situated in the tank.
    Type: Application
    Filed: November 13, 2006
    Publication date: August 21, 2008
    Applicant: Robert Bosch GmbH
    Inventors: Peter Schelhas, Manfred Franz, Andreas Posselt, Andreas Baumann, Martin Streib, Michael Pfeil, Marko Lorenz, Silke Haag
  • Publication number: 20080187967
    Abstract: The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is located within a working chamber or is adjacent to it. A pressure gradient in relation to ambient pressure prevails in both the insulator and in the working chamber.
    Type: Application
    Filed: December 13, 2007
    Publication date: August 7, 2008
    Applicant: MERZ PHARMA GMBH & CO. KGAA
    Inventors: Bernd Doelle, Michael Pfeil
  • Publication number: 20080034843
    Abstract: A method of diagnosing a fuel tank leak in a fuel tank ventilation system, comprising a fuel tank, an accumulator for fuel vapors and a fuel tank ventilation valve opening out into an intake manifold of an internal combustion engine, wherein the fuel tank, the accumulator and the fuel tank ventilation valve are connected by way of a system of lines and wherein the accumulator has an aeration line with a check valve, the method comprising: immediately before turning off the internal combustion engine, closing the check valve and opening the fuel tank ventilation valve to generate a vacuum in the fuel tank ventilation system; acquiring a vacuum degradation at specifiable points in time when the fuel tank ventilation valve is closed; opening of the check valve in order to bring about a pressure equilibrium with the ambient pressure; renewed closing of the check valve; acquiring a pressure increase emerging over at least a specifiable time interval and determination of a compensation variable; and inference about
    Type: Application
    Filed: July 23, 2007
    Publication date: February 14, 2008
    Applicant: Robert Bosch GmbH
    Inventors: Martin Streib, Karl-Bernhard Lederle, Michael Pfeil
  • Publication number: 20070262549
    Abstract: A hydraulic system incorporated into a vehicle is provided. The system includes a plurality of actuators for providing a desired configuration of a vehicle. A valve system is operatively coupled to the plurality of actuators for controlling a flow of pressurized fluid to the plurality of actuators to energize the actuators to produce, responsive to the desired configuration of the vehicle, a first configuration of a plurality of first configurations of the vehicle corresponding to the desired configuration of the vehicle, or a second configuration of a plurality of second configurations of the vehicle corresponding to the desired configuration of the vehicle.
    Type: Application
    Filed: May 12, 2006
    Publication date: November 15, 2007
    Inventors: Timothy Haerr, Gary Fulks, Michael Pfeil
  • Publication number: 20070079650
    Abstract: A method of and an apparatus for checking the tightness of a tank system of an internal combustion engine of a motor vehicle by means of overpressure or underpressure, in which a first controllable valve is disposed in a connection between the tank system and an overpressure or underpressure source, and a second controllable valve is disposed in a connection of the tank system with the ambient air in which the leak testing is performed at the end of a phase of operation of the engine, in particular at the end of a travel mode, of a motor vehicle that has the engine, and a demand for shutoff of the engine is executed with a time delay, and at least the steps of the leak testing that generate the overpressure or underpressure are performed within the delay time.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 12, 2007
    Inventors: Martin Streib, Karl-Bernhard Lederle, Michael Pfeil
  • Publication number: 20060255550
    Abstract: An auxiliary lean control system is provided for controlling a lean angle of at least a portion of a vehicle. The auxiliary lean control system includes an energy storage device for storing energy to actuate the lean control system, a stabilizing mechanism coupled to the energy storage device and to the at least a portion of the vehicle for applying energy received from the energy storage device to the at least a portion of the vehicle to adjust the lean angle of the at least a portion of a vehicle, and a linkage coupled to the energy storage device and to the stabilizing mechanism for transferring energy from the energy storage device to the stabilizing mechanism. The auxiliary lean control system controls the lean angle of the portion of the vehicle in an absence of control of the lean angle by a primary lean control system.
    Type: Application
    Filed: May 12, 2006
    Publication date: November 16, 2006
    Inventors: Michael Pfeil, Gary Fulks, Timothy Haerr, Scott Saiki, Andrew Roth
  • Patent number: 7073376
    Abstract: A method for testing the functionality of a tank system of a motor vehicle having an internal combustion engine, including a controllable tank venting valve connected to an intake manifold and at least one pressure source for testing the tightness of the tank venting system using overpressure or underpressure, the functionality of the tank venting valve being tested via its activation in an opening and/or closing manner during pressurizing the tank system using overpressure or underpressure and by registering and evaluating at least one operating variable of the pressure source. The tank system is pressurized with overpressure or underpressure and the at least one operating variable of the pressure source is registered and evaluated during operation of the engine.
    Type: Grant
    Filed: January 18, 2005
    Date of Patent: July 11, 2006
    Assignee: Robert Bosch GmbH
    Inventors: Armin Hassdenteufel, Karl-Bernhard Lederle, Michael Pfeil, Andreas Mueller
  • Publication number: 20060089777
    Abstract: A method for balancing brake force is disclosed. The method includes determining whether a deceleration value reaches a first deceleration threshold in response to a braking event and determining brake condition and vehicle motion. Based on brake condition and vehicle motion determination and the first deceleration threshold determination, the method determines whether the deceleration value reaches a second deceleration threshold, and applies threshold balancing when the second deceleration threshold is reached.
    Type: Application
    Filed: October 22, 2004
    Publication date: April 27, 2006
    Inventors: Bryan Riddiford, Michael Pfeil, Richard Thomas
  • Patent number: 6988494
    Abstract: A method for operating an internal combustion engine, permitting a differentiation between an air error and a fuel error as part of mixture adaptation. In at least one operating state of the internal combustion engine a deviation in an air-fuel mixture ratio from a setpoint value is corrected. For this correction in the at least one operating state the particular deviation in the air-fuel mixture ratio is determined for at least two setpoint values. From these deviations an air error and/or a fuel error is determined.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: January 24, 2006
    Assignee: Robert Bosch GmbH
    Inventors: Armin Hassdenteufel, Michael Pfeil
  • Patent number: 6970775
    Abstract: A method of tank leak diagnosis in a tank ventilation device including a fuel tank which is connected at least indirectly through a storage and tank ventilation valve with a suction pipe of an internal combustion engine of the vehicle, with the storage having an aeration conduit with a check valve, includes performing a tank leak diagnosis by a negative pressure after turning off of the internal combustion engine; and producing the negative pressure in the fuel tank immediately before the turning off of the internal combustion engine.
    Type: Grant
    Filed: February 25, 2004
    Date of Patent: November 29, 2005
    Assignee: Robert Bosch GmbH
    Inventors: Karl-Bernhard Lederle, Michael Pfeil, Nicolas Perrot