Abstract: The disclosure relates to an aluminum alloy plate having a final thickness of 3 inch or more, and a method for manufacturing same. In the method, an aluminum alloy with a chemical composition of in weight percent: Mg 4.0 to 5.2, Mn 0.4 to 1.0, Zn?0.3, Zr?0.3, Cr?0.3, Ti?0.3, Fe<0.50, Si<0.45, Cu<0.25, other elements and unavoidable impurities each <0.05 total <0.20 balance aluminum, is cast, preheated and/or homogenized, hot rolled, cold rolled with a cold rolling reduction of 3 to 10%, and stretched directly after cold rolling with a permanent elongation of 0.7 to 5% in the direction of stretching.

Abstract: The disclosure relates to an aluminum alloy plate having a final thickness of 3 inch or more, and a method for manufacturing same. In the method, an aluminum alloy with a chemical composition of in weight percent: Mg 4.0 to 5.2, Mn 0.4 to 1.0, Zn?0.3, Zr?0.3, Cr?0.3, Ti?0.3, Fe<0.50, Si<0.45, Cu<0.25, other elements and unavoidable impurities each <0.05 total <0.20 balance aluminum, is cast, preheated and/or homogenized, hot rolled, cold rolled with a cold rolling reduction of 3 to 10%, and stretched directly after cold rolling with a permanent elongation of 0.7 to 5% in the direction of stretching.

Abstract: A non-invasive injectable composition that contains type I collagen, an osteogenic growth factor (OSF), such as a bone morphogenetic protein and a reverse thermo-sensitive biodegradable polymer such as Poloxamer 407 in an aqueous vehicle. The formulation can be administered non-invasively, e.g., by injection, thus circumventing limitations of many currently marketed bone-inducing products. The injectable osteogenic formulation effectively induces bone formation at the desired locale. This injectable suspension could be used with bioresorbable bone mineral composites (e.g., Hydroxyapatite, Tri-calcium phosphate) and/or glycosaminolycans (e.g., Hyaluronic acid, Heparin sulfate) to mold as putty and/slab as bone graft substitute implants to induce new bone formation in fracture healing and spine fusion procedures.

Abstract: A non-invasive injectable composition that contains type I collagen, an osteogenic growth factor (OSF), such as a bone morphogenetic protein and a reverse thermo-sensitive biodegradable polymer such as Poloxamer 407 in an aqueous vehicle. The formulation can be administered non-invasively, e.g., by injection, thus circumventing limitations of many currently marketed bone-inducing products. The injectable osteogenic formulation effectively induces bone formation at the desired locale. This injectable suspension could be used with bioresorbable bone mineral composites (e.g., Hydroxyapatite, Tri-calcium phosphate) and/or glycosaminoglycans (e.g., Hyaluronic acid, Heparin sulfate) to mold as putty and/slab as bone graft substitute implants to induce new bone formation in fracture healing and spine fusion procedures.

Abstract: The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.

Abstract: This invention relates to compositions, methods of preparation thereof, and use thereof for cartilage repair.

Abstract: The invention relates to a method for manufacturing a product comprising an AlCu alloy comprising (weight per cent): Cu: 3.8-5.5 Mg: 0.2-0.8 Mn: 0.2-0.6 Ag 0.2-0.5 Si<0.15 Fe<0.20 Zn<0.25 Cr<0.05 Zr<0.10, Ti<0.15 others <0.05, remainder aluminium. In an embodiment the method comprises naturally aging the product forming in at least one process, such as stretch forming, drawing, flow spinning, and/or bending and artificial aging at a temperature from 280 to 340° F. (138 to 171° C.) for a duration from 6 to 36 hours. The method is particularly useful to make armor products.

Abstract: This invention relates to compositions, methods of preparation thereof, and use thereof for cartilage repair.

Abstract: The present invention relates to a heparin-derivatized collagen matrix comprising a fragment of heparin covalently linked to a collagen scaffold, wherein the fragment of heparin has molecular weight of less than about 15 kDa, and at least one heparin-binding growth factor (HBGF) or heparin-binding adeno-associated virus (HB-AAV) or a combination thereof and methods for promoting bone growth, bone repair, cartilage repair, bone development, neo-angiogensis, wound healing, tissue engraftment and muscle tissue regeneration and/or tissue augmentation comprising administering a heparin-derivatized collagen matrix that includes at least one heparin-binding growth factor or heparin-binding adeno-associated virus or a combination thereof.