Patents by Inventor Michael Piatak
Michael Piatak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6084073Abstract: DNA sequences encoding full length precursor proteins, which proteins contain both A and B portions of two ricin isotoxins and ricin agglutinin, as well as the linker regions have been determined. These DNAs or portions or modifications thereof are expressed in recombinant hosts to obtain the desired proteins or proteins which can readily converted thereto. One of the ricin isotoxins may be related to ricin E.Type: GrantFiled: June 5, 1995Date of Patent: July 4, 2000Assignee: Chiron CorporationInventor: Michael Piatak, Jr.
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Patent number: 6022953Abstract: Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are also described. These multifunctional M-CSF proteins have increased therapeutic potential.Type: GrantFiled: April 27, 1995Date of Patent: February 8, 2000Assignee: Chiron CorporationInventors: Peter Ralph, George Martin, Michael Piatak, James W. Larrick
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Patent number: 5858734Abstract: Recombinant vectors and methods for constructing ricin B are disclosed. The coding sequence for ricin B was cloned, disposed in suitable expression vectors and produced free of components normally accompanying this peptide. In addition, a novel means of reconstructing missing portions of coding sequence, and certain improvements in messenger RNA purification are disclosed.Type: GrantFiled: June 5, 1995Date of Patent: January 12, 1999Assignee: Chiron CorporationInventors: Glenn Thomas Horn, Michael Piatak, Jr.
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Patent number: 5840522Abstract: DNA sequences encoding full length precursor proteins, which proteins contain both A and B portions of two ricin isotoxins and ricin agglutinin, as well as the linker regions have been determined. These DNAs or portions or modifications thereof are expressed in recombinant hosts to obtain the desired proteins or proteins which can readily converted thereto. One of the ricin isotoxins may be related to ricin E.Type: GrantFiled: May 9, 1995Date of Patent: November 24, 1998Assignee: Chiron CorporationInventor: Michael Piatak, Jr.
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Patent number: 5567611Abstract: Multifunctional proteins having M-CSF activity and at least one other bioactivity not found together in a single naturally occuring molecule are described. These multifunctional M-CSF proteins can be produced by the expression of fused genes which are also described. These multifunctional M-CSF proteins have increased therapeutic potential.Type: GrantFiled: December 12, 1994Date of Patent: October 22, 1996Assignee: Cetus Onocology CorporationInventors: Peter Ralph, George Martin, Michael Piatak, James W. Larrick
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Patent number: 5538868Abstract: Recombinant vectors and methods for constructing ricin B are disclosed. The coding sequence for ricin B was cloned, disposed in suitable expression vectors and produced free of components normally accompanying this peptide. In addition, a novel means of reconstructing missing portions of coding sequence, and certain improvements in messenger RNA purification are disclosed.Type: GrantFiled: January 23, 1995Date of Patent: July 23, 1996Assignee: Cetus Oncology CorporationInventors: Glenn T. Horn, Michael Piatak, Jr.
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Patent number: 5166056Abstract: Disclosed are the entire coding sequence for unprocessed and mature trichosanthin from Trichosanthes kirilowii, and primers derived from this coding sequence for use in obtaining the coding sequences of ribosome inactivating proteins which have regions of amino acid sequence identical to those of trichosanthin. Also disclosed is a recombinant trichosanthin protein produced from the coding sequence, and the mature protein with amino-terminal and/or carboxy-terminal extensions.Type: GrantFiled: December 9, 1991Date of Patent: November 24, 1992Assignee: Genelabs IncorporatedInventors: Michael Piatak, Jr., Theresa P. Chow
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Patent number: 5128460Abstract: Disclosed are the entire protein and nucleic acid coding sequences for unprocessed and mature trichosanthin protein from Trichosanthes kirilowii. A recombinant trichosanthin protein produced from the coding sequence, and the trichosanthin protein with amino-terminal and/or carboxy-terminal extensions are also described. Primers derived from the coding sequence are disclosed for use in obtaining the coding sequences of ribosome-inactivating-proteins which have regions of amino acid sequence identical to those of trichosanthin. Further, a multigene family of ribosome-inactivating-protein encoding genes of Trichosanthes kirilowii is also described.Type: GrantFiled: April 4, 1990Date of Patent: July 7, 1992Assignee: Genelabs IncorporatedInventors: Michael Piatak, Jr., Theresa P. Chow, Kirk Fry
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Patent number: 5101025Abstract: Disclosed are the entire coding sequence for unprocessed and mature trichosanthin from Trichosanthes kirilowii, and primers derived from this coding sequence for use in obtaining the coding sequences of ribosome inactivating proteins which have regions of amino acid sequence identical to those of trichosanthin. Also disclosed is a recombinant trichosanthin protein produced from the coding sequence, and the mature protein with amino-terminal and/or carboxy-terminal extensions.Type: GrantFiled: September 7, 1989Date of Patent: March 31, 1992Assignee: Genelabs IncorporatedInventors: Michael Piatak, Jr., Theresa P. Chow
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Patent number: 5079163Abstract: Ricin B muteins, ricin and ricin precursors having at least one amino acid of at least one galactoside binding site altered to decrease the binding of ricin B to galactosides are claimed. DNA sequences encoding the ricin B muteins, ricin and ricin precursor in which the B chain thereof is the ricin B mutein are claimed. Recombinant expression vectors effective in expressing the DNA sequences of the ricin B muteins, ricin and ricin precursors are claimed. Host cells transformed with the foregoing expression vectors are also claimed. Conjugates comprising binding moieties such as antibodies, hormones, and lymphokines bound to the ricin B mutein and ricin wherein the B chain thereof is the mutein is also claimed.Type: GrantFiled: March 12, 1987Date of Patent: January 7, 1992Assignee: Cetus CorporationInventors: Michael Piatak, Jr., L. L. Houston, Anne W. Emerick
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Patent number: 4948729Abstract: A system for expression of coding sequences for desired heterologous proteins in procaryotic hosts whereby the protein is produced intracellularly in soluble, biologically active form, is disclosed. The expression is obtained by ligation of the coding sequence downstream of, and proximally to, but out of reading frame with, the terminated leader encoding sequence for a secreted bacterial protein, such as alkaline phosphatase. The resultant proteins are influenced by the leader sequence codons to effect the desired three-dimensional conformation, but not to effect secretion.Type: GrantFiled: March 17, 1988Date of Patent: August 14, 1990Assignee: Cetus CorporationInventors: Michael Piatak, Jr., Walter J. Laird, Julie A. Lane