Abstract: Embodiments of the invention provide a medical implant, and method for deploying the same, configured for placement in a body lumen such as a coronary sinus, as may be desired to treat a regurgitant mitral valve. The implant includes a proximal anchor, a distal anchor, and an elongate bridge extending between the proximal and distal anchors. The anchors are configured to be delivered to a desired deployment site within the body lumen in a collapsed or contracted condition and then expanded to engage the walls of the body lumen. The bridge is preferably a shape-changing member configured to contract after delivery into the coronary sinus for applying a compressive force to the annulus of the mitral valve. The proximal and distal anchoring mechanisms preferably overlap the proximal and distal end portions of the bridge, thereby providing the implant with a longer bridge having greater contraction.

Abstract: The present invention relates to the use of extracts from Cimicifuga racemosa, and of tectorigenin as an estrogen-type, organoselective medicament for the selective treatment and/or prophylaxis of cardiovascular diseases, atherosclerosis, osteoporosis and climacteric disorders, e.g. for preventing or alleviating hot flushes. Uterotrophic effects are practically not observed.

Abstract: The present invention relates to the use of phytoestrogen-containing extracts that selectively modulate estrogen receptor beta (ER-beta) without producing any uterotropic effect, for the treatment of clinical situations and pathophysiological conditions that are selected from the group consisting of: Obesity and thereby to possibly influence the metabolic syndrome, particularly hypertension, asterosclerosis, cardiac infarct, hyperandrogenemia; Menopausal continence disorders; Menopausal heat surges associated with hyperstimulation of the hypothalamic gonadotropin releasing hormone pulse generator; steroid hormonal synthesis disorder, particularly that of progesterone synthesis of the human corpus luteum, resulting in luteal insuffeciency; Alzheimer's disease associated with elevated expression of estrogen receptor beta in hippocampal neurons.

Abstract: The present invention relates to the use of extracts from Iridaceae and from Cimicifuga racemosa, and of tectorigenin as an estrogen-type, organoselective medicament for the selective treatment and/or prophylaxis of cardiovascular diseases, in particular atherosclerose, osteoporose and climacteric disorders, e.g. for preventing or alleviating hot flushes. Uterotrophic effects are practically not observed.

Abstract: The present invention relates to extracts from the lridaceae plant Belamcanda chinensis for producing a ready-formulated medicament suited for the selective treatment and/or prophylaxis of sexual hormone-related disorders of the uro-genital tract. The inventive extracts are moreover suited for the treatment and/or prophylaxis of post-menopausal bladder infections and of urinary incontinence. The are moreover indicated for the treatment of benign and malignant prostate hyperplasies. It was moreover found that the ingredient tectorigenin as well as its glycosides, isolated from Belamcanda chinensis, essentially has the same effects as the whole extract.

Abstract: The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane type.

Abstract: The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane or clerodane type: wherein R1=H, C1 to C3 alkyl or C1 to C3 acyl.

Abstract: Cooling of engine walls with fuel, wherein the walls have a structure which has an inner wall, to which hot gas is admitted during the operation, a colder outer wall, as well as a plurality of webs which connect the walls and divide the hollow space present there into a plurality of cooling ducts.The fuel is introduced in the cold state into the wall structure, is delivered through the cooling ducts while absorbing heat via the inner wall, and is subsequently used to generate thrust.A hot fluid flow taken from the engine is admitted during the operation from the outside to the "cold" outer wall of the wall structure, through which fuel flows, and this "cold" outer wall thermally expands as a result, or its thermal contraction is reduced.