Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.

Abstract: Methods and systems are provided for predictive shoulder kinematics via immersive virtual reality. In one example, a system comprises an immersive virtual reality (iVR) system, the iVR system including a headset and a hand-held controller, and machine readable instructions executable to: predict joint kinematics using a machine learning model based on motion data received from the iVR system during gameplay of a virtual reality-guided exercise with the iVR system. In this way, physical rehabilitation may be performed remotely with increased evaluation accuracy.

Abstract: The present injection apparatus is designed for replenishing embedded foundation preservation wraps with preservative whilst avoiding spillage. The injection apparatus comprises an injection bayonet having a lumen fluidly interfacing a plurality of preservative outlet nozzles along the injection bayonet and a preservative inlet fluidly interfacing the lumen. A portable preservative containing tank may be attached to the inlet via a flexible hose. The apparatus further comprises a syringe operating between the preservative inlet and the lumen. When replenishing the preservation wrap, the injection bayonet is inserted between the preservation wrap and the foundation so that preservative is configured to be supplied via the preservative inlet to flow out from the nozzles via the lumen to replenish the preservation wrap with the preservative. After replenishment, the lumen is purged of residual preservative using the syringe.

Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.

Abstract: Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.

Abstract: Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.

Abstract: The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.

Abstract: Semi-submersible wind turbine platforms capable of floating on a body of water and supporting wind turbines, and a method of manufacturing the semi-submersible wind turbine platforms from advanced cementitious composite material are provided. The method includes determining at a first iteration topological outputs of the wind turbine platform including a plurality of modular sections consisting of an advanced cementitious composite (ACC) material, obtaining a second iteration from the topological outputs, the second iteration including a second model platform and a second model tower of the wind turbine platform, and obtaining addition iterations via simulation to attain a final model platform and a final model tower, the final model platform and the final model tower including a layout of the plurality of modular sections and connections for a platform and a tower of the wind turbine platform.

Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.

Abstract: Semi-submersible wind turbine platforms capable of floating on a body of water and supporting wind turbines, and a method of manufacturing the semi-submersible wind turbine platforms from advanced cementitious composite material are provided. The method includes determining at a first iteration topological outputs of the wind turbine platform including a plurality of modular sections consisting of an advanced cementitious composite (ACC) material, obtaining a second iteration from the topological outputs, the second iteration including a second model platform and a second model tower of the wind turbine platform, and obtaining addition iterations via simulation to attain a final model platform and a final model tower, the final model platform and the final model tower including a layout of the plurality of modular sections and connections for a platform and a tower of the wind turbine platform.

Abstract: Semi-submersible wind turbine platforms capable of floating on a body of water and supporting wind turbines, and a method of manufacturing the semi-submersible wind turbine platforms from advanced cementitious composite material are provided. The method includes determining at a first iteration topological outputs of the wind turbine platform including a plurality of modular sections consisting of an advanced cementitious composite (ACC) material, obtaining a second iteration from the topological outputs, the second iteration including a second model platform and a second model tower of the wind turbine platform, and obtaining addition iterations via simulation to attain a final model platform and a final model tower, the final model platform and the final model tower including a layout of the plurality of modular sections and connections for a platform and a tower of the wind turbine platform.

Abstract: The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.

Abstract: Semi-submersible wind turbine platforms capable of floating on a body of water and supporting wind turbines, and a method of manufacturing the semi-submersible wind turbine platforms from advanced cementitious composite material are provided. The method includes determining at a first iteration topological outputs of the wind turbine platform including a plurality of modular sections consisting of an advanced cementitious composite (ACC) material, obtaining a second iteration from the topological outputs, the second iteration including a second model platform and a second model tower of the wind turbine platform, and obtaining addition iterations via simulation to attain a final model platform and a final model tower, the final model platform and the final model tower including a layout of the plurality of modular sections and connections for a platform and a tower of the wind turbine platform.

Abstract: A motor vehicle having a vehicle body, an engine compartment (10) housing an engine (12) and a bonnet seal arrangement (30, 34). The bonnet seal arrangement defines an opening (35) and is configured to deflect ram air received at the front of the motor vehicle (2) in use past the opening (35) to define a first air flow path, and draw air from the first air flow path through the opening (35) to define a second air flow path for supplying air to the intake duct orifice (42), the second air flow path being angled in a horizontal plane to the first air flow path.

Abstract: In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.

Abstract: The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.

Abstract: A method of manufacturing a mat is provided. The method involves securing a first layer formed of a polymer within a base die, positioning an intermediate cushion layer on top of the first layer, securing a second layer formed of the polymer to the base die, and securing a perimeter of the first layer to a perimeter of the second layer by radio-frequency welding, so as to envelop the intermediate cushion layer within the first and second layers and thereby form the mat. The first layer has a first surface and an opposing second surface in contact with the base die. The intermediate cushion layer has a first surface and an opposing second surface in contact with the first surface of the first layer. The second layer has a first surface and an opposing second surface in contact with the first surface of the intermediate cushion layer.

Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.

Abstract: The present application relates to a compositions and methods comprising or expressing a HEVAR or MOMO30 protein derived from Momordica balsamina. The HEVAR or MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for treating or preventing viral infections, particularly those caused by coronaviruses, such as SARS-CoV-2.

Abstract: The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.