Patents by Inventor Michael Puhl

Michael Puhl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11685759
    Abstract: The present invention relates to a method for obtaining crystalline 2?-fucosyllactose from a 2?-FL raw material, which contains 2?-FL as a main constituent and at least 0.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: June 27, 2023
    Assignee: BASF SE
    Inventors: Michael Puhl, Sebastian Wloch, Peter Oedman, Anne-Catrin Letzel, Hartwig Schroeder, Jacek Malisz, Daniel Seibert-Ludwig, Emiel Jan Kappert, Chung Huan Wong, Michael Barros Gross, Martin Viertelhaus
  • Patent number: 11673874
    Abstract: The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R1, R2 and R3 independently of each other are selected from hydrogen and methyl, R4 is selected from C-1-C6-alkyl, and X is selected from C1-C20-alkyl and C2-C20-alkenyl.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: June 13, 2023
    Assignee: BASF SE
    Inventors: Melanie Weingarten, Wolfgang Siegel, Michael Puhl
  • Publication number: 20220259580
    Abstract: The present disclosure relates to methods for producing human milk oligosaccharide (HMO) core structures using glycosidases from family GH20 hexosaminidases. In particular, the present disclosure provides methods for producing lacto-N-triose II (LNT II) and/or lacto-N-tetraose (LNT) by reacting glucosamine-oxazoline and/or lacto-N-biose-oxazoline with lactose catalysed by an enzyme of the glycoside hydrolase family 20 (GH20) according to the classification of the Carbohydrate-Active-Enzymes (CAZy) database. Specific optimized enzymes are identified to catalyse the reactions.
    Type: Application
    Filed: December 9, 2019
    Publication date: August 18, 2022
    Inventors: Kai-Uwe Baldenius, Michael Breuer, Corinna Ruffer, Melanie Weingarten, Reinhard Zschoche, Stefan Seemayer, Bernd Nidetzky, Katharina Schmoelzer, Michael Puhl
  • Patent number: 11414449
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: August 16, 2022
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Publication number: 20220041638
    Abstract: The present invention relates to a method for separating biomass from a solution comprising biomass and at least one oligosaccharide.comprising providing the solution comprising biomass and oligosaccharides.lowering the pH value of the solution below 7 by adding at least one acid to the solution comprising biomass and the at least one oligosaccharide. adding an adsorbing agent to the solution comprising biomass and oligosaccharides. and carrying out first membrane filtration so as to separate the biomass from the solution comprising the at least one oligosaccharide.
    Type: Application
    Filed: December 17, 2019
    Publication date: February 10, 2022
    Inventors: Jacek MALISZ, Daniel SEIBERT-LUDWIG, Peter OEDMAN, Michael PUHL
  • Publication number: 20210388014
    Abstract: The present invention relates to a method for obtaining crystalline 2?-fucosyllactose from a 2?-FL raw material, which contains 2?-FL as a main constituent and at least 0.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 16, 2021
    Inventors: Michael PUHL, Sebastian WLOCH, Peter OEDMAN, Anne-Catrin LETZEL, Hartwing SCHROEDER, Jacek MALISZ, Daniel SEIBERT-LUDWIG, Emiel Jan KAPPERT, Chung Huan WONG, Michael BARROS GROSS, Martin VIERTELHAUS
  • Publication number: 20210309626
    Abstract: The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R1, R2 and R3 independently of each other are selected from hydrogen and methyl, R4 is selected from hydrogen and C1-C6-alkanoyl, and X is selected from C1-C20-alkyl and C2-C20-alkenyl.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 7, 2021
    Inventors: Melanie WEINGARTEN, Wolfgang SIEGEL, Michael PUHL
  • Publication number: 20210309627
    Abstract: The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R1, R2 and R3 independently of each other are selected from hydrogen and methyl, R4 is selected from C-1-C6-alkyl, and X is selected from C1-C20-alkyl and C2-C20-alkenyl.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 7, 2021
    Inventors: Melanie WEINGARTEN, Wolfgang SIEGEL, Michael PUHL
  • Patent number: 11098075
    Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose, the 2?-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(?O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: August 24, 2021
    Assignee: BASF SE
    Inventors: Michael Puhl, Klaus Ditrich, Andreas Keller, Pepa Dimitrova, Melanie Weingarten, Wolfgang Siegel
  • Publication number: 20210171489
    Abstract: The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.
    Type: Application
    Filed: August 16, 2019
    Publication date: June 10, 2021
    Inventors: Melanie WEINGARTEN, Wolfgang SIEGEL, Michael PUHL
  • Publication number: 20210130384
    Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose, the intermediates obtainable by this method and the use of these intermediates. The preparation comprises the reaction of a protected fucose of the general formula (I) with a tri(C1-C6-alkyl)silyl iodide to give a protected 1-iodofucose followed by the reaction of the protected 1-iodofucose with a compound of the general formula (II), in the presence of at least one base and deprotecting the resulting coupling product to afford 2?-O-fucosyllactose.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 6, 2021
    Inventors: MICHAEL PUHL, Wolfgfang SIEGEL, Stephanie RENZ, Andreas WÖLFERT
  • Patent number: 10988499
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: April 27, 2021
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Patent number: 10851128
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-0-ficosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: December 1, 2020
    Assignee: BASF SE
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Publication number: 20200048295
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-O-fucosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2 H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Publication number: 20200048294
    Abstract: This invention describes new hydrated and anhydrous polymorphs of 2?-0-ficosyllactose (2?FL): Polymorph A 2?FL-3/2H2O, Polymorph B 2TL-5/2H2O and anhydrous Polymorph C. There is also a description of the methods for obtaining them, and of a new method for preparing Polymorph I already known in the literature.
    Type: Application
    Filed: April 24, 2019
    Publication date: February 13, 2020
    Inventors: Giovanni Cipolletti, Gessica Laudati, Liana Salsini, Michael Puhl
  • Patent number: 10428361
    Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: October 1, 2019
    Assignee: BASF SE
    Inventors: Vaidotas Navickas, Michael Breuer, Michael Puhl, Melanie Weingarten, Kai-Uwe Baldenius, Wolfgang Siegel
  • Publication number: 20190100547
    Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose and to the protected fucosyl donor of the formula (I) used in this method. The method comprises reacting the fucose derivative of the formula (I) below with the compound of the general formula (II), in the presence of an activating reagent.
    Type: Application
    Filed: March 8, 2017
    Publication date: April 4, 2019
    Inventors: MICHAEL PUHL, Stephanie RENZ, Andreas WOELFERT
  • Publication number: 20180230176
    Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose, the 2?-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(?O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.
    Type: Application
    Filed: September 11, 2015
    Publication date: August 16, 2018
    Inventors: MICHAEL PUHL, Klaus DITRICH, Andreas KELLER, Pepa DIMITROVA, Melanie WEINGARTEN, Wolfgang SIEGEL
  • Publication number: 20180073047
    Abstract: The present invention relates to biocatalytic methods, comprising purely enzymatic, mixed enzymatic-fermentative and purely fermentative methods, for the direct single-step conversion of L-fucitol to L-fucose, in order to easily obtain L-fucose at high amounts and levels of purity. Suitable recombinant microorganisms and fungi are further disclosed and also the use thereof in said method for the single-step conversion to L-fucose.
    Type: Application
    Filed: February 19, 2016
    Publication date: March 15, 2018
    Inventors: Vaidotas NAVICKAS, Michael BREUER, Michael PUHL, Melanie WEINGARTEN, Kai-Uwe BALDENIUS, Wofgang SIEGEL
  • Publication number: 20170015649
    Abstract: N-Thio-anthranilamid compounds of formula (I) wherein A is A1 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.
    Type: Application
    Filed: June 13, 2016
    Publication date: January 19, 2017
    Inventors: Thomas SCHMIDT, Michael PUHL, Joachim DICKHAUT, Henricus Maria Martinus BASTIAANS, Michael RACK, Deborah L. CULBERTSON, Douglas D. ANSPAUGH, Franz-Josef BRAUN, Toni BUCCI, Henry Van Tuyl COTTER, David G. KUHN, Hassan OLOUMI-SADEGHI