Patents by Inventor Michael R. Barbachyn

Michael R. Barbachyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5547950
    Abstract: A compound of structural Formula I: ##STR1## or pharmaceutically acceptable salts thereof wherein: each n is independently 1 to 3; Y is chosen from a-n as defined herein; wherein each occurrence of said C.sub.1-6 alkyl may be substituted with one or more F, Cl, Br, I, OR.sup.1, CO.sub.2 R.sup.1, CN, SR.sup.1, or R.sup.1 (where R.sup.1 is a hydrogen or C.sub.1-4 alkyl); X and Z are independently C.sub.1-6 alkyl, C.sub.3-12 cycloalkyl or hydrogen, or X and Z form a C.sub.0-3 bridging group, preferably X and Z are hydrogen; U, V and W are independently C.sub.1-6 alkyl, F, Cl, Br, hydrogen or a C.sub.1-6 alkyl substituted with one or more of F, Cl, Br or I, preferably U and V are F and W is hydrogen; R is hydrogen, C.sub.1-12 alkyl, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkyl substituted with one or more F, Cl, Br, I or OH; and q is 0 to 4 inclusive.
    Type: Grant
    Filed: October 31, 1994
    Date of Patent: August 20, 1996
    Assignee: The Upjohn Company
    Inventors: Douglas K. Hutchinson, Michael R. Barbachyn, Steven J. Brickner, Ronald B. Gammill, Mahesh V. Patel
  • Patent number: 5523403
    Abstract: A novel class of phenyloxazolidinone antibacterial agents which have, as their salient structural feature, an appended substituted tropone moiety, are described. Intermediates and processes for the preparation of these antibiotics are also disclosed. These compounds are useful antibacterial agents to eradicate or control susceptible organisms. ##STR1## wherein R.sup.4 is oxygen substituted heptatrienyl and R.sup.1, R.sup.2, and R.sup.3 are as defined herein.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: June 4, 1996
    Assignee: The Upjohn Company
    Inventor: Michael R. Barbachyn
  • Patent number: 5385906
    Abstract: A quinolone compound of Formula (I) ##STR1## as defined herein having antibacteria properties, pharmaceutical compositions containing the quinoline compound and method for treating bacterial infections in animals including humans.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: January 31, 1995
    Assignee: The Upjohn Company
    Inventors: Ronald B. Gammill, Sharon N. Bisaha, Joseph M. Timko, Thomas M. Judge, Michael R. Barbachyn, Kyoung S. Kim
  • Patent number: 5262417
    Abstract: A quinolone compound of Formula (I) ##STR1## as defined herein having antibacteria properties, pharmaceutical compositions containing the quinoline compound and method for treating bacterial infections in animals including humans.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: November 16, 1993
    Assignee: The Upjohn Company
    Inventors: Ronald B. Gammill, Sharon N. Bisaha, Joseph M. Timko, Thomas M. Judge, Michael R. Barbachyn, Kyoung S. Kim
  • Patent number: 5006650
    Abstract: This invention presents novel 2-azetidinone compounds of the formula ##STR1## wherein R.sub.10 and R.sub.15 are the same or different and are (a) hydrogen, (b) (C.sub.1 -C.sub.12) alkyl, (c) (C.sub.2 -C.sub.8) alkenyl, (d) (C.sub.2 -C.sub.8) alkynyl, (e) --CH.sub.2 OCOCH.sub.2 NHR.sub.4, (f) --CH.sub.2 OCO.sub.2 R.sub.30, (g) --CH.sub.2 F, or (h) --CHF.sub.2 ; wherein R.sub.4 is hydrogen or --COH; wherein R.sub.30 is (C.sub.1 -C.sub.8)alkyl; wherein R.sub.20 is an acyl group derived from a carboxylic acid; wherein A is oxygen or sulfur; and wherein R.sub.70 is (a) hydrogen, (b) (C.sub.1 -C.sub.8) alkyl, (c) phenyl, (d) --OH, or (e) --SH; where each member of b or c may optionally be substituted by 1 to 2 substituents selected from the group consisting of halogen, hydroxy, and amino.These compounds are useful as antibacterial agents to eradicate or control susceptible microbes. Intermediates and processes for making these compounds are also disclosed.
    Type: Grant
    Filed: August 7, 1989
    Date of Patent: April 9, 1991
    Assignee: The Upjohn Company
    Inventor: Michael R. Barbachyn
  • Patent number: 4975538
    Abstract: This invention presents novel 2-azetidinone compounds which are useful as antibacterial agents to eradicate or control susceptible microbes of the formula ##STR1## wherein R.sub.401 and R.sub.402 are the same or different and are (a) hydrogen, (b) (C.sub.1 -C.sub.12) alkyl (c) (C.sub.2 -C.sub.8) alkenyl, (d) (C.sub.2 -C.sub.8) alkynyl, (e) (C.sub.3 -C.sub.10) cycloalkyl, (f) phenyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C.sub.1 -C.sub.4) alkyl, and (C.sub.1 -C.sub.4) alkoxy, (g) benzyl optionally substituted with from one to 3 substituents selected from the group consisting of halogen, hydroxy, amino, nitro, (C.sub.1 -C.sub.4) alkyl, and (C.sub.1 -C.sub.4) alkoxy, (h) --CH.sub.2 --O--CO--CH.sub.2 --NHR.sub.420, (i) --CH.sub.2 --O--CO.sub.2 --R.sub.430, (j) --CH.sub.2 F, or (k) --CHF.sub.2 ; wherein R.sub.420 is (a) hydrogen, (b) --COH, or (c) --CO--O--C(CH.sub.3).sub.3 ; wherein R.sub.430 is (C.sub.1 -C.sub.8) alkyl, --(CH.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: December 4, 1990
    Assignee: The Upjohn Company
    Inventors: Michael R. Barbachyn, Steven J. Brickner, Richard C. Thomas