Patents by Inventor Michael R. Boyd

Michael R. Boyd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
    Patent number: 5571919
    Abstract: The present invention provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: November 5, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gerhard Bringmann, Sven Harmsen, Michael R. Boyd
  • Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
    Patent number: 5552550
    Abstract: The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The invention also provides new, medically useful naphthylisoquinoline compounds and derivatives thereof.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: September 3, 1996
    Assignee: The United States of America, as represented by the Department of Health and Human Services
    Inventors: Gerhard Bringmann, Roland G otz, Michael R. Boyd
  • Michellamine antiviral agents, compositions, and treatment methods
    Patent number: 5455251
    Abstract: The present invention provides new antiviral compounds, i.e., michellamines and derivatives and pharmacologically acceptable salts thereof, methods for isolating such antiviral compounds from a plant species of the genus Ancistrocladus, antiviral compositions containing such antiviral compounds, and methods of using such antiviral compounds for treating patients with viral infections. The antiviral compounds of the present invention inhibit the reproduction and cytopathicity of human acquired immunodeficiency viruses.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: October 3, 1995
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael R. Boyd, John H. Cardellina, II, Kirk P. Manfredi, John W. Blunt, Lewis K. Pannell, James B. McMahon, Robert J. Gulakowski, Gordon M. Cragg, Gerhard Bringmann, Duncan Thomas, Johnson Jato
  • Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
    Patent number: 5409938
    Abstract: The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: April 25, 1995
    Assignee: The United States of America as represented by the Secretary, Department of Health and Human Services
    Inventors: Michael R. Boyd, Guido Francois, Gerhard Bringmann, Yaii F. Hallock, Kirk P. Manfredi, John H. Cardellina, II
  • Antitumor compound, compositions and method of use
    Patent number: 5283383
    Abstract: The present invention relates to a new antitumor compound, a method for isolating same from a red alga, antitumor compositions containing same and methods of using same for treating patients with cancer. The compound of the present invention is 6(R)-bromo-3(S)-bromomethyl-7-methyl-2,3,7-trichloro-1-octene.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: February 1, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael R. Boyd, John H. Cardellina, II, Richard W. Fuller, Kenneth M. Snader, Jon Clardy