Patents by Inventor Michael R. Briggs

Michael R. Briggs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human peroxisome proliferator activated receptor gamma (ppar?) gene regulatory sequences and uses therefor
    Patent number: 7098025
    Abstract: This invention relates to the isolation and cloning of the promoter and other control regions of human PPAR? gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of the PPAR? gene. These agents interact directly or indirectly with the promoter or other control regions of the PPAR? gene.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: August 29, 2006
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Johan Auwerx, Lluis Fajas, Michael R. Briggs, Regis Saladin
  • Modulators of ob gene and screening methods therefor
    Patent number: 6068976
    Abstract: This invention relates to the isolation and cloning of the promoter and other control regions of a human ob gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level of expression of an ob gene. These agents interact directly or indirectly with the promoter or other control regions of the ob gene. A PPAR.gamma. agonist, BRL49653, has been identified to be useful in treating anorexia, cachexia, and other diseases characterized by insufficient food intake or body weight loss. Modulators of ob gene expression may be used to treat other diseases such as obesity, diabetes, hypertension, cardiovascular diseases and infertility.
    Type: Grant
    Filed: March 19, 1996
    Date of Patent: May 30, 2000
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Michael R. Briggs, Johan Auwerx, Piet de Vos, Bart Staels, Glenn E. Croston, Stephen G. Miller
  • Methods relating tosterol regulatory element binding proteins
    Patent number: 5891631
    Abstract: A sterol regulatory element (SRE) binding protein (SREBP) which activates transcription from SREs, such as SRE-1 of the low intensity lipoprotein (LDL) receptor gene, is disclosed, as are DNA segments encoding SREBPs such as an SREBP-1 or SREBP-2. Also described are methods for using SREBP to promote SRE-mediated transcription and LDL receptor production in the presence of sterols, and screening assay for the identification of further agents with such properties. The SREBP and other agents may be used to reduce plasma cholesterol levels and to treat various medical problems associated with hypercholesterolemia.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: April 6, 1999
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joseph L. Goldstein, Michael S. Brown, Michael R. Briggs, Xiaodong Wang
  • Methods and compositions relating to sterol regulatory element binding proteins
    Patent number: 5527690
    Abstract: A sterol regulatory element (SRE) binding protein (SREBP) which activates transcription from SREs, such as SRE-1 of the low density lipoprotein (LDL) receptor gene, is disclosed, as are DNA segments encoding SREBPs such as an SREBP-1 or SREBP-2. Also described are methods for using SREBP to promote SRE-mediated transcription and LDL receptor production in the presence of sterols, and screening assay for the identification of further agents with such properties. The SREBP and other agents may be used to reduce plasma cholesterol levels and to treat various medical problems associated with hypercholesterolemia.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: June 18, 1996
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joseph L. Goldstein, Michael S. Brown, Michael R. Briggs, Xiaodong Wang
  • Sterol regulatory element binding proteins and their use in screening assays
    Patent number: 5498696
    Abstract: A nuclear protein which binds sterol regulatory elements (SREs), such as SRE-1 of the low density lipoprotein (LDL) receptor gene, and mediates sterol-regulated transcription of the LDL receptor gene is disclosed. Also described are screening assay and methods for the identification of agents capable of promoting LDL receptor gene transcription for use in reducing plasma cholesterol and treating the various medical problems associated therewith.
    Type: Grant
    Filed: May 13, 1993
    Date of Patent: March 12, 1996
    Assignee: Board of Regents, The University of Texas System
    Inventors: Michael R. Briggs, Michael S. Brown, Joseph L. Goldstein, Xiaodong Wang