Patents by Inventor Michael R. De Felippis

Michael R. De Felippis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monomeric insulin analog formulations
    Patent number: 5952297
    Abstract: The present invention discloses various parenteral pharmaceutical formulations having a protracted effect, which comprise: a sterile aqueous suspension of about 20 U/mL to about 500 U/mL insulin analog, about 5 mg/mL to about 10 mg/mL sodium chloride, about 0.2 to about 2.0 mg/mL physiologically acceptable buffer, a zinc ion content of about 0.07 mg/mL to about 0.1 mg/mL, and a physiologically acceptable preservative at a pH of about 6.5 to about 7.8; such that less than 5% of the analog present in the suspension is in the dissolved state.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: September 14, 1999
    Assignee: Eli Lilly and Company
    Inventors: Michael R. De Felippis, Bruce H. Frank
  • Monomeric insulin analog formulations
    Patent number: 5747642
    Abstract: The present invention discloses various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analog, zinc, protamine, and phenolic derivative. The analog formulations provide a prolonged duration of action. A process for preparing insulin analog-protamine formulations is also described.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: May 5, 1998
    Assignee: Eli Lilly and Company
    Inventor: Michael R. De Felippis
  • Monomeric insulin analog formulations
    Patent number: 5650486
    Abstract: The present invention discloses various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analog, zinc, protamine, and phenolic derivative. The analog formulations provide a prolonged duration of action. A process for preparing insulin analog-protamine formulations is also described.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: July 22, 1997
    Assignee: Eli Lilly and Company
    Inventor: Michael R. De Felippis
  • Insulin analog formulations
    Patent number: 5547929
    Abstract: The present invention discloses various parenteral pharmaceutical formulations, which comprise a mixture of a monomeric insulin analog and insulin-NPH. The analog formulations provide a rapid onset and a prolonged duration of action.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: August 20, 1996
    Assignee: Eli Lilly and Company
    Inventors: James H. Anderson, Jr., Michael R. De Felippis, Bruce H. Frank, Henry A. Havel
  • Monomeric insulin analog formulations
    Patent number: 5461031
    Abstract: The present invention discloses various parenteral pharmaceutical formulations, which comprise: a monomeric insulin analog, zinc, protamine, and phenolic derivative. The analog formulations provide a prolonged duration of action. A process for preparing insulin analog-protamine formulations is also described.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: October 24, 1995
    Assignee: Eli Lilly and Company
    Inventor: Michael R. De Felippis