Patents by Inventor Michael R. Farzan

Michael R. Farzan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID ENCODING FUSION POLYPEPTIDES THAT PREVENT OR INHIBIT HIV INFECTION
    Publication number: 20110305670
    Abstract: The present invention is directed to an isolated nucleic acid molecule encoding a fusion polypeptide the expression of which in cells is capable of blocking the entry of HIV-1 into host cells and methods of using the nucleic acid molecule.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 15, 2011
    Applicant: President and Fellows of Harvard College
    Inventor: Michael R. Farzan
  • Polypeptides derived from anti-HIV-1 gp120 antibodies that abrogate gp120 binding to CCR5
    Patent number: 7488481
    Abstract: The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain.
    Type: Grant
    Filed: February 5, 2004
    Date of Patent: February 10, 2009
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Michael R. Farzan, Tatyana K. Dorfman
  • Peptides binding gp120 of HIV-1
    Publication number: 20040192609
    Abstract: The present invention is directed to peptides that are capable of blocking the entry of HIV-1 into host cells by means of the CCR5 receptor. The affinity of the peptides for gp120 on the HIV viral surface may be increased by sulfating tyrosine residues. In addition, the invention is directed to a method for increasing the affinity of antibodies for their antigens by sulfating tyrosine residues in the antibody amino acid chain.
    Type: Application
    Filed: February 5, 2004
    Publication date: September 30, 2004
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Michael R. Farzan, Tatyana K. Dorfman