Patents by Inventor Michael R. Green

Michael R. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11963975
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: April 23, 2024
    Assignee: University of Massachusetts
    Inventors: Peter L. Jones, Michael R. Green
  • Patent number: 11873494
    Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: January 16, 2024
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Minggang Fang
  • Publication number: 20230416779
    Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
    Type: Application
    Filed: May 3, 2023
    Publication date: December 28, 2023
    Applicant: University of Massachusetts
    Inventors: Miguel Sena Esteves, Guangping Gao, Michael R. Green, Dan Wang, Tessa Mercedes Simone
  • Patent number: 11819554
    Abstract: The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene. In some aspects, methods described by the disclosure are useful for treating a FMR1-inactivation-associated disorder (e.g., fragile X syndrome).
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: November 21, 2023
    Assignees: UNIVERSITY OF MASSACHUSETTS, FULCRUM THERAPEUTICS, INC.
    Inventors: Michael R. Green, Minggang Fang, Walter Kowtoniuk
  • Patent number: 11680275
    Abstract: In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: June 20, 2023
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Guangping Gao, Michael R. Green, Dan Wang, Tessa Mercedes Simone
  • Patent number: 11478529
    Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: October 25, 2022
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Guangping Gao, Manas Kumar Santra, Sanchita Bhatnagar
  • Publication number: 20220259654
    Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
    Type: Application
    Filed: January 27, 2022
    Publication date: August 18, 2022
    Applicant: University of Massachusetts
    Inventors: Michael R. Green, Sanchita Bhatnagar
  • Publication number: 20220226364
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
    Type: Application
    Filed: April 6, 2022
    Publication date: July 21, 2022
    Applicant: University of Massachusetts
    Inventors: Peter L. Jones, Michael R. Green
  • Publication number: 20220186227
    Abstract: Compositions and methods for treating cancers containing an oncogenic KRAS mutant.
    Type: Application
    Filed: March 28, 2020
    Publication date: June 16, 2022
    Inventors: Michael R. Green, Dong-Hwan Kim
  • Publication number: 20220152083
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
    Type: Application
    Filed: September 30, 2021
    Publication date: May 19, 2022
    Applicant: University of Massachusetts
    Inventors: Peter L. Jones, Michael R. Green
  • Patent number: 11268150
    Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: March 8, 2022
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Sanchita Bhatnagar
  • Publication number: 20220042023
    Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).
    Type: Application
    Filed: August 19, 2021
    Publication date: February 10, 2022
    Inventors: Michael R. Green, Minggang Fang
  • Patent number: 11189119
    Abstract: Aspects of the invention are directed towards method system and devices assisting a user in providing seamless access to a user through an access point of the access system. The invention describes estimating various factors such as time, distance, and signal strength enabling frictionless access to the user. The invention describes adjusting the time interval and the signal strength according to the needs of the user. Various other embodiments of the invention describes estimating a threshold signal strength and time interval based on a distance of the user from the access point.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: November 30, 2021
    Assignee: CARRIER CORPORATION
    Inventors: Krishnakanth Jarugumilli, Mahesh Dhumpeti, Gokul Ellanki, Anil Kumar Varturi, Rajesh Krishna Etikela, Sriram Narasimha Murthy Dulam, Michael R. Green, Kishore Maroju, Ashley Kennedy-Foster
  • Patent number: 11160823
    Abstract: The disclosure relates to methods and compositions for regulating expression of DUX4. In some aspects, methods described by the disclosure are useful for treating a disease associated with aberrant DUX4 expression (e.g., facioscapulohumeral muscular dystrophy).
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: November 2, 2021
    Assignee: University of Massachusetts
    Inventors: Peter L. Jones, Michael R. Green
  • Publication number: 20210317529
    Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
    Type: Application
    Filed: June 10, 2020
    Publication date: October 14, 2021
    Applicant: University of Massachusetts
    Inventors: Michael R. Green, Sanchita Bhatnagar
  • Publication number: 20210292766
    Abstract: Methods that include inhibition of ROCK1/2 and other protein kinases to treat Friedreich Ataxia.
    Type: Application
    Filed: August 29, 2019
    Publication date: September 23, 2021
    Inventors: Michael R. Green, Minggang Fang
  • Patent number: 11124795
    Abstract: Methods of treating subjects having disorders associated with mutations in the FXN gene and/or having reduced expression of frataxin protein, e.g., Friedreich ataxia (FA). Generally, the methods include administering a therapeutically effective amount of an agent that increases expression of frataxin protein as described herein, e.g., an inhibitor of a FXN Repressing Factor (FXN-RF).
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: September 21, 2021
    Assignee: University of Massachusetts
    Inventors: Michael R. Green, Minggang Fang
  • Publication number: 20210019966
    Abstract: Aspects of the invention are directed towards method system and devices assisting a user in providing seamless access to a user through an access point of the access system. The invention describes estimating various factors such as time, distance, and signal strength enabling frictionless access to the user. The invention describes adjusting the time interval and the signal strength according to the needs of the user. Various other embodiments of the invention describes estimating a threshold signal strength and time interval based on a distance of the user from the access point.
    Type: Application
    Filed: July 10, 2020
    Publication date: January 21, 2021
    Inventors: Krishnakanth Jarugumilli, Mahesh Dhumpeti, Gokul Ellanki, Anil Kumar Varturi, Rajesh Krishna Etikela, Sriram Narasimha Murthy Dulam, Michael R. Green, Kishore Maroju, Ashley Kennedy-Foster
  • Publication number: 20200377952
    Abstract: In some aspects, the disclosure relates to the reactivation of inactive X chromosomes (Xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive X chromosomes. In some embodiments, the compositions and methods described by the disclosure may be useful for the treatment of dominant X-linked diseases.
    Type: Application
    Filed: June 10, 2020
    Publication date: December 3, 2020
    Applicant: University of Massachusetts
    Inventors: Michael R. Green, Sanchita Bhatnagar
  • Publication number: 20200276266
    Abstract: Methods of treating a tumor in a subject include identifying a subject having, at risk for, or suspected of having a tumor, and administering to the subject an effective amount of an SRPX.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 3, 2020
    Inventors: Michael R. Green, Guangping Gao, Manas Kumar Santra, Sanchita Bhatnagar