Abstract: Disclosed herein are compact systems for performing targeted temperature management including one or more thermal pad assemblies, each or which includes a thermoelectric device. The thermoelectric device heats or cools a thermal exchange fluid circulating within the thermal contact pad to warm or cool a patient. The thermoelectric device may be included in a temperature control module directly attached to the pad. A modularized temperature control module may selectively include one or more thermoelectric devices coupled with a heat exchanger. Logic stored in memory may, via execution of one or more processors, control the temperature of the thermal exchange fluid by defining a polarity and magnitude of an electrical power supplied to the thermoelectric device. The temperature control module may be selectively attached to and detached from the pad. A pre-use unassembled state of the thermal pad assembly include the pad having the thermal exchanged fluid sealed therein.

Abstract: Disclosed herein are medical systems, pads, and methods for exchanging thermal energy between a circulating fluid and a patient. Some pads are configured multiple uses on the same patient or across multiple different patients. Some pads include multiple layers of hydrogel disposed on one or both sides a fluid compartment. Removable hydrogel layers expose other hydrogel layers for subsequent uses of the pad. Removable storage liners encapsulate one or multiple hydrogel layers. Separation liners between adjacent hydrogel layers isolate the adjacent hydrogels from each other and removal of the separation liner extends the operational life a hydrogel layer. Adhesive patches secure the pads to the patient including adhesive patches extending through openings of a pad. Some pads are configured for disinfection, sterilization and/or laundering. In an embodiment, the fluid is air and a vacuum within a compartment of the pad secures the pad to the patient.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 cal/hr-cm-° C.

Abstract: Disclosed herein are systems and methods for providing targeted temperature management (TTM) therapy to a patient. Systems included herein provide an airflow to the patient in additional to a liquid flow that define a thermal energy exchange with the patient. Various systems may provide air at a defined TTM temperature to a thermal contact pad, a mattress or a ventilator that delivers the TTM air to the patient via the ventilation therapy. Also disclosed herein are systems, devices, and methods for preventing, managing, and/or removing perspiration moisture from between the thermal contact pad and the patient. Disclosed herein is a thermal contact pad includes a wicking material to draw moisture away from the patient. Disclosed herein also is a thermal contact pad including airflow that draws moisture away from the patient.

Abstract: Disclosed herein is a medical pad for exchanging thermal energy between a targeted temperature management (TTM) fluid and a patient. The medical pad includes a fluid containing layer configured for circulation of a TTM fluid therein. The pad is configured to expand together with an expansion of the patient's skin. A fluid containing layer of the pad includes openings extending therethrough to facilitate expansion. The pad further includes tabs extending away from a perimeter edge, so that a clinician may apply a lifting force to the tab to separate a proximate portion of the pad away from the patient. The pad further includes a hydrogel layer formed of an ultraviolet light-cured composition.

Abstract: Disclosed herein a blanket apparatus and systems and methods pertaining to the same. The blanket includes a body portion formed of fabric, wherein the fabric is elastomer or elastomer-based and a first pocket within the body portion and surrounded by the fabric, wherein the first pocket is an enclosed area filled with an insulative material, and wherein the blanket is configured to be placed on at least a first thermal pad of a targeted temperature management (TTM) system, wherein the first pocket is configured to provide a weight on top of the first thermal pad. The insulative material may be an insulative gel, paste or granular material. In some instances, a length of the first pocket is substantially an entirety of a length of the blanket. Additionally, in some instances, a width of the first pocket is substantially an entirety of a width of the blanket.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca/hr-cm-° C.

Abstract: Disclosed are systems, pads, and methods for targeted temperature management. For example, a pad can include a multilayered pad body, a pad inlet connector, and a pad outlet connector. The pad body can include a conduit layer and a patient-interfacing layer over the conduit layer. The conduit layer can include one or more conduits configured to convey a temperature-controlled fluid as a supply fluid from a hydraulic system and a return fluid back to the hydraulic system. The patient-interfacing layer can be configured for placement on a portion of a patient's body. The patient-interfacing layer can have a patient-facing side including a plurality of wells configured to hold a thermally conductive medium. The pad inlet connector can include a pad inlet configured for charging the conduit layer with the supply fluid. The pad outlet connector can include a pad outlet configured for discharging the return fluid from the conduit layer.

Abstract: Disclosed are systems and methods for hyperthermic cancer treatment. For example, a system can include a heat exchanger, a control module, a primary fluid delivery line (“FDL”), an intravenous catheter, and a peristaltic pump. The control module can include at least a hydraulic system configured to provide a temperature-controlled fluid. The primary FDL can be configured to convey the temperature-controlled fluid to the heat exchanger as a supply fluid and back to the hydraulic system as a return fluid. The intravenous catheter can include a primary lumen configured to convey blood of the patient to the heat exchanger as well as a secondary lumen configured to convey the blood back to the patient using the peristaltic pump. The catheter can also include a thermistor for determining a core body temperature of the patient to ensure the patient is in a hyperthermic state before administering a cancer treatment to the patient.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca/hr-cm-° C.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca//hr-cm-° C.

Abstract: A medical pad for exchanging thermal energy between a targeted temperature management (TTM) fluid and a patient. The medical pad includes a fluid containing layer configured for circulation of a TTM fluid therein. The pad may further include a bistable stiffening structure configured to transition between a first stable shape and a second stable shape. The pad may further include a thermally-conductive compressible foam layer disposed between the fluid containing layer and a patient contact side of the pad. a self-adhering stretchable band configured to secure the pad to the patient. The pad may further include a semi-permeable layer disposed between an underside of the fluid containing layer and a hydrogel layer so that the TTM fluid may migrate from the fluid containing layer to the hydrogel layer.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca//hr-cm-° C.

Abstract: Disclosed herein are systems, pads, and methods for targeted temperature management. For example, a pad can include a multilayered pad body, a pad inlet connector, and a pad outlet connector. The pad body can include a conduit layer and a non-adhesive, thermally conductive layer over the conduit layer. The conduit layer can include one or more conduits configured to convey a temperature-controlled fluid as a supply fluid from a hydraulic system of a control module. The one-or-more conduits can also configured to convey the temperature-controlled fluid as a return fluid back to the hydraulic system. The conductive layer can be configured for placement on a portion of a patient's body. The pad inlet connector can include a pad inlet configured for charging the conduit layer with the supply fluid. The pad outlet connector can include a pad outlet configured for discharging the return fluid from the conduit layer.

Abstract: Disclosed herein are targeted temperature management (“TTM”) systems, pads, and methods thereof for treating burn wounds. A method of a system for TTM can include a pad-connecting step, a pad-placing step, and a fluid-circulating step. The pad-connecting step can include connecting an inlet and an outlet of a pad to a hydraulic system of a control module. The pad can include a multilayered pad body having a conduit layer configured to convey a temperature-controlled fluid provided by the control module. The pad-placing step can include placing the pad on a wounded portion of a patient's body with a sterile, thermally conductive wound-healing layer of the pad body in contact with a burn wound of the wounded portion of the patient's body. The fluid-circulating step can include circulating the temperature-controlled fluid through the conduit layer to cool the wounded portion of the patient's body, thereby treating the wound to promote healing.

Abstract: Disclosed herein are systems, pads, and methods thereof for targeted temperature management. In an example, a pad for targeted temperature management can include a pad body, a conduit system, one or more inlets, and one or more outlets. The pad body can be of a conformable material configured to conform to a body of a patient on the pad. The conduit system can be disposed in the pad body or an overlayer configured for placement over the pad body. The conduit system can include one or more conduits configured to convey a fluid through the pad body or the overlayer. The one-or-more inlets can be configured for charging the conduit system with the fluid, while the one-or-more outlets can be configured for discharging the fluid from the conduit system. Methods of the systems and pads can include methods of use. In another example, a deformable pad can be configured for receiving a neonatal patient.

Abstract: Disclosed herein are systems, pads, and methods thereof for targeted temperature management. A first pad can include a multilayered pad body and an inflatable cuff around the pad body. The pad body can include a conformable layer, a conduit layer over the conformable layer, and an insulation layer over the conduit layer. The conformable layer can include a conformable material configured to conform around a limb of a patient. The conduit layer can include one or more conduits configured to convey a fluid through the conduit layer. The insulation layer can be configured to insulate the conduit layer from an ambient temperature of an environment around the patient. The inflatable cuff can be configured to press the pad body against the limb of the patient when the inflatable cuff is inflated. Methods of the systems and pads can include methods of use.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer can include an ultraviolet light-cured composition with a cross-linking copolymer, water, and glycerol. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 ca//hr-cm-° C.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer comprises an ultra violet light-cured composition that includes a cross-linking copolymer in an amount of between about 15% to 30% by weight of the composition, water in an amount of between about 15% to 40% by weight of the composition, and glycerol in an amount of between about 25% to 35% by weight of the composition. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 cal/hr-cm-° C.

Abstract: An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer comprises an ultra violet light-cured composition that includes a cross-linking copolymer in an amount of between about 15% to 30% by weight of the composition, water in an amount of between about 15% to 40% by weight of the composition, and glycerol in an amount of between about 25% to 35% by weight of the composition. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 cal/hr-cm-° C.