Patents by Inventor Michael R. Holbrook

Michael R. Holbrook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6958151
    Abstract: Disclosed are polypeptides which include an amino acid sequence corresponding to CCXXXCKEGXXC (SEQ ID NO:1). Also disclosed are methods for inhibiting the activity of a flavivirus or other virus by contacting the virus with a miniprotein ligand under conditions effective for the miniprotein ligand to bind to the virus. Methods for detecting a flavivirus or other virus in a sample by contacting the sample with a miniprotein ligand and determining whether the miniprotein ligand is bound to a flavivirus or other virus as also disclosed, as are methods of assessing a compound's usefulness in inhibiting the activity of a flavivirus or other virus.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: October 25, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Robert O. Fox, Alan D. Barrett, Xiuzhen Fan, Michael R. Holbrook
  • Publication number: 20040002582
    Abstract: Disclosed are polypeptides which include an amino acid sequence corresponding to CCXXXCKEGXXC (SEQ ID NO:1). Also disclosed are methods for inhibiting the activity of a flavivirus or other virus by contacting the virus with a miniprotein ligand under conditions effective for the miniprotein ligand to bind to the virus. Methods for detecting a flavivirus or other virus in a sample by contacting the sample with a miniprotein ligand and determining whether the miniprotein ligand is bound to a flavivirus or other virus as also disclosed, as are methods of assessing a compound's usefulness in inhibiting the activity of a flavivirus or other virus.
    Type: Application
    Filed: March 17, 2003
    Publication date: January 1, 2004
    Inventors: Robert O. Fox, Alan D. Barrett, Xiuzhen Fan, Michael R. Holbrook
  • Patent number: 4431374
    Abstract: The present invention is an improvement in radial diffusers employed in a turbine engine having a centrifugal compressor. The walls of the diffuser define at least one flow passage through the diffuser having a first portion with a first cross-sectional area and a second portion having a larger, second cross-sectional area. The first wall section is spaced apart from the second wall section so as to define a bleed aperture therebetween. A vortex fence extends outwardly from the wall surface at the leading edge of the second wall portion. Preferably, the bleed aperture and the vortex fence are disposed on the suction surface of each vane in a vaned radial diffuser.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: February 14, 1984
    Assignee: Teledyne Industries, Inc.
    Inventors: Eli H. Benstein, Gerald D. Stringham, Michael R. Holbrook
  • Patent number: 4131389
    Abstract: The subject compressor is of the centrifugal type having a rotatable impeller with hub and shroud sides and a diffuser surrounding the impeller, the diffuser having spaced side walls with vanes spaced around the impeller to provide passages for receiving fluid discharged from the impeller, the diffuser also having chambers formed on the hub and shroud sides and restricted openings along lines of static pressure in the diffuser passages establishing communication between the chambers and the diffuser passages near the inlet ends thereof whereby the pressures at such passage inlet ends will be equalized during the operation of the compressor and the tendency of the compressor to stall prematurely thereby reduced. Suitable communication between the chambers on the hub and shroud sides may be provided.
    Type: Grant
    Filed: April 25, 1977
    Date of Patent: December 26, 1978
    Assignee: The Garrett Corporation
    Inventors: George L. Perrone, Robert W. Boorman, Michael R. Holbrook, Eugene A. Zanelli