Patents by Inventor Michael R. Kerns

Michael R. Kerns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for growth of intestinal cells in microfluidic devices
    Patent number: 11952592
    Abstract: Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: April 9, 2024
    Assignee: EMULATE, INC.
    Inventors: S. Jordan Kerns, Norman Wen, Carol Lucchesi, Christopher David Hinojosa, Jacob Fraser, Jefferson Puerta, Geraldine Hamilton, Robert Barrett, Clive Svendsen, Daniel Levner, Stephen R Targan, Michael Workman, Dhruv Sareen, Uthra Rajamani, Magdalena Kasendra
  • Methods of creating drought tolerant corn plants using markers linked to cold shock domain-containing proteins and compositions thereof
    Patent number: 11032986
    Abstract: The present invention is in the field of plant breeding and drought tolerance. More specifically, the invention includes a method for breeding corn plants containing one or more markers that are associated with tolerance to low water conditions. Markers provided herein include markers genetically linked to proteins comprising cold shock domains, such as the CSD1 and CSD2 proteins. The invention further includes germplasm and the use of germplasm containing at least one marker associated with drought tolerance for introgression into elite germplasm in a breeding program, thus producing drought resistant germplasm. Other embodiments of this invention include transgenic drought tolerant corn plants and corn plant cells, and methods of detecting drought tolerance genes and chromosome regions associated with drought tolerance in a plant genome.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: June 15, 2021
    Assignee: Monsanto Technology LLC
    Inventors: Paul S. Chomet, Nancy M. Houmard, Hongwu Jia, Michael R. Kerns, Mark E. Leibman
  • Methods and compositions for Goss' Wilt resistance in corn
    Patent number: 10844399
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: November 24, 2020
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods and compositions for gray leaf spot resistance in corn
    Patent number: 10760095
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: September 1, 2020
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • METHODS OF CREATING DROUGHT TOLERANT CORN PLANTS USING MARKERS LINKED TO COLD SHOCK DOMAIN-CONTAINING PROTEINS AND COMPOSITIONS THEREOF
    Publication number: 20200015444
    Abstract: The present invention is in the field of plant breeding and drought tolerance. More specifically, the invention includes a method for breeding corn plants containing one or more markers that are associated with tolerance to low water conditions. The invention further includes germplasm and the use of germplasm containing at least one marker associated with drought tolerance for introgression into elite germplasm in a breeding program, thus producing drought resistant germplasm. Other embodiments of this invention include transgenic drought tolerant corn plants and corn plant cells, and methods of detecting drought tolerance genes and chromosome regions associated with drought tolerance in a plant genome.
    Type: Application
    Filed: June 18, 2019
    Publication date: January 16, 2020
    Inventors: Paul S. Chomet, Nancy M. Houmard, Hongwu Jia, Michael R. Kerns, Mark E. Leibman
  • Methods and Compositions for Gray Leaf Spot Resistance in Corn
    Publication number: 20190316146
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 17, 2019
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and Compositions for Goss' Wilt Resistance in Corn
    Publication number: 20190276839
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Application
    Filed: May 23, 2019
    Publication date: September 12, 2019
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods of creating drought tolerant corn plants using markers linked to cold shock domain-containing proteins and compositions thereof
    Patent number: 10383295
    Abstract: The present invention is in the field of plant breeding and drought tolerance. More specifically, the invention includes a method for breeding corn plants containing one or more markers that are associated with tolerance to low water conditions. Markers provided herein include markers genetically linked to proteins comprising cold shock domains, such as the CSD1 and CSD2 proteins. The invention further includes germplasm and the use of germplasm containing at least one marker associated with drought tolerance for introgression into elite germplasm in a breeding program, thus producing drought resistant germplasm. Other embodiments of this invention include transgenic drought tolerant corn plants and corn plant cells, and methods of detecting drought tolerance genes and chromosome regions associated with drought tolerance in a plant genome.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: August 20, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Paul S. Chomet, Nancy M. Houmard, Hongwu Jia, Michael R. Kerns, Mark E. Leibman
  • Methods and compositions for gray leaf spot resistance in corn
    Patent number: 10323255
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: June 18, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and compositions for Goss' Wilt resistance in corn
    Patent number: 10301644
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 28, 2019
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods and Compositions for Gray Leaf Spot Resistance in Corn
    Publication number: 20180080040
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 22, 2018
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and Compositions for Goss' Wilt Resistance in Corn
    Publication number: 20180044697
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Application
    Filed: October 24, 2017
    Publication date: February 15, 2018
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods and compositions for gray leaf spot resistance in corn
    Patent number: 9862966
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: January 9, 2018
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and compositions for Goss' Wilt resistance in corn
    Patent number: 9828610
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 28, 2017
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • METHODS AND COMPOSITIONS FOR GRAY LEAF SPOT RESISTANCE IN CORN
    Publication number: 20160024519
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 28, 2016
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and Compositions for Goss' Wilt Resistance in Corn
    Publication number: 20150322536
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 12, 2015
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods and compositions for Goss' Wilt resistance in corn
    Patent number: 9119365
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: September 1, 2015
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters
  • Methods and compositions for gray leaf spot resistance in corn
    Patent number: 9095113
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 4, 2015
    Assignee: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and Compositions for Gray Leaf Spot Resistance in Corn
    Publication number: 20140298531
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Gray Leaf Spot, a fungal disease associated with Cercospora spp.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Gilberto Pozar, Kevin Cook, Scott Walker, Gregory Holland
  • Methods and Compositions for Goss' Wilt Resistance in Corn
    Publication number: 20140283222
    Abstract: The present invention relates to the field of plant breeding. More specifically, the present invention includes a method of using haploid plants for genetic mapping of traits of interest such as disease resistance. Further, the invention includes a method for breeding corn plants containing quantitative trait loci (QTL) that are associated with resistance to Goss' Wilt, a bacterial disease associated with Clavibacter michiganense spp.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 18, 2014
    Applicant: Monsanto Technology LLC
    Inventors: Michael R. Kerns, Hongwu Jia, David Butruille, Travis J. Frey, Kevin Cook, Laron Peters