Patents by Inventor Michael R. Krout

Michael R. Krout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Steroid compounds as RORyt modulators and uses thereof
    Patent number: 9505798
    Abstract: Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: November 29, 2016
    Assignees: New York University, Memorial Sloan-Kettering Cancer Center
    Inventors: Dan R. Littman, Jun R. Huh, Nicolas Gabriel Albert Manel, Daniel A. Ryan, David Y. Gin, Mary S. Gin, Michael R. Krout
  • STEROID COMPOUNDS AS RORyt MODULATORS AND USES THEREOF
    Publication number: 20140066391
    Abstract: Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
    Type: Application
    Filed: November 28, 2011
    Publication date: March 6, 2014
    Inventors: Dan R. Littman, Jun R. Huh, Nicolas Gabriel Albert Manel, Michael R. Krout, Daniel A. Ryan
  • N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
    Patent number: 7763659
    Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: July 27, 2010
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Barbara Hanney, Yuntae Kim, Michael R. Krout, Robert S. Meissner, Helen J. Mitchell, Jeffrey Musselman, James J. Perkins, Jiabing Wang
  • -(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
    Patent number: 7629367
    Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: December 8, 2009
    Assignee: Merck & Co., Inc.
    Inventors: Barbara Hanney, Yuntae Kim, Michael R. Krout, Robert S. Meissner, Helen J. Mitchell, Jeffrey Musselman, James J. Perkins, Jiabing Wang
  • N-(2-Benzyl)-2-Phenylbutanamides As Androgen Receptor Modulators
    Publication number: 20080139630
    Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.
    Type: Application
    Filed: June 3, 2005
    Publication date: June 12, 2008
    Inventors: Barbara Hanney, Yuntae Kim, Michael R. Krout, Robert S. Meissner, Helen J. Mitchell, Jeffrey Musselman, James J. Perkins, Jiabing Wang
  • N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
    Patent number: 7268153
    Abstract: Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: September 11, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Barbara Hanney, Yuntae Kim, Michael R. Krout, Robert S. Meissner, Helen J. Mitchell, Jeffrey Musselman, James J. Perkins, Jiabing Wang