Patent number: 6376472
Abstract: A compound of the formula
wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl
where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and n and p are independently 0, 1, 2, or 3, provided that n+p is at least 1;
T is hydrogen, alkyl, alkylcarbonyl, alkylthiocarbonyl, halo, carboxyl,
A and B are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR′;
or a pharmaceutically acceptable salt thereof, a pharmaceutic-ally acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.
Type:
Grant
Filed:
October 16, 1998
Date of Patent:
April 23, 2002
Assignee:
Aventis Pharmaceuticals, Inc.
Inventors:
Michael R. Myers, Martin P. Maguire, Alfred P. Spada, William R. Ewing, Henry W. Pauls, Yong Mi Choi-Sledeski