Patents by Inventor Michael R. Olin

Michael R. Olin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Annexin II variant compositions and methods
    Patent number: 10206986
    Abstract: This disclosure describes polypeptides fragments of annexin II, variants thereof, compositions that includes such fragments and/or variants, and methods of using such frag and/or variants.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 19, 2019
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: John R. Ohlfest, Michael R. Olin
  • Annexin II compositions
    Patent number: 10117928
    Abstract: The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: November 6, 2018
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: John R. Ohlfest, Michael R. Olin
  • ANNEXIN II COMPOSITIONS AND METHODS
    Publication number: 20170128570
    Abstract: The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.
    Type: Application
    Filed: December 27, 2016
    Publication date: May 11, 2017
    Inventors: John R. Ohlfest, Michael R. Olin
  • Annexin II compositions
    Patent number: 9555074
    Abstract: The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 31, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: John R. Ohlfest, Michael R. Olin
  • ANNEXIN II VARIANT COMPOSITIONS AND METHODS
    Publication number: 20160279212
    Abstract: This disclosure describes polypeptides fragments of annexin II, variants thereof, compositions that includes such fragments and/or variants, and methods of using such frag and/or variants.
    Type: Application
    Filed: November 13, 2014
    Publication date: September 29, 2016
    Inventors: John R. Ohlfest, Michael R. Olin
  • ANNEXIN II COMPOSITIONS AND METHODS
    Publication number: 20130331546
    Abstract: The present invention provides compositions and methods that involve the 36 kDa annexin II monomer, which has been identified as having immunostimulatory properties. Accordingly, in one aspect, the invention provides compositions that include at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that include administering to a subject a composition that includes at least one 36 kDa annexin II monomer or an immunomodulatory fragment thereof. In another aspect, the invention provides methods that induce an in situ increase in the 36 kDa annexin II monomer by administering to a subject an amount of composition effective to induce localized hypoxia sufficient to cause a localized increase in annexin II.
    Type: Application
    Filed: October 7, 2011
    Publication date: December 12, 2013
    Inventors: John R. Ohlfest, Michael R. Olin