Abstract: The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: Disclosed are antibodies and antibody drug conjugates having an Fc region with substitutions resulting in essentially a silent Fc region. The antibodies and antibody drug conjugates described herein are useful for the depletion of cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting, e.g., a population of CD45+ or CD117+ cancer cells or CD45+ autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: An EV charging system includes an enclosure and an EV charger disposed therein. The enclosure includes a frame having four frame rails, a top bracket and a bottom bracket, upper and lower covers supported in the frame, a front panel supported in the frame and having an opening with an access for accessing an interior portion of the enclosure, a component box supported in the frame, and a hanger assembly for mounting the enclosure to a preexisting structure. The charger includes an EV charging unit, a connector accessible through the access door of the front panel, a cable for delivering charging current from the EV charging unit to the connector, and a cable retraction mechanism for retracting the cable into the interior. The access door is prevented from opening unless proper credentials are presented.

Abstract: An LED luminaire includes an LED engine system that drives a plurality of interchangeable LED modules. The LED engine system may be arranged in a luminaire housing. The LED engine system includes a power plate assembly and a plurality of LED modules that are removable and interchangeable with respect to the power plate assembly. The LED engine system is customizable or modifiable to vary the light output therefrom, in that various types of LED modules may be utilizable therewith and one or more of the LED modules may be mounted to the power plate assembly at two or more orientations.

Abstract: An LED luminaire includes an LED engine system that drives a plurality of interchangeable LED modules. The LED engine system may be arranged in a luminaire housing. The LED engine system includes a power plate assembly and a plurality of LED modules that are removable and interchangeable with respect to the power plate assembly. The LED engine system is customizable or modifiable to vary the light output therefrom, in that various types of LED modules may be utilizable therewith and one or more of the LED modules may be mounted to the power plate assembly at two or more orientations.

Abstract: A lighting array assembly has a plurality of support members facing different directions and on which emitters are mounted. Each support member has an emitter circuit thereon in operative association with at least one emitter and has a lighting center point. The emitters on each support member are positioned together around the lighting center point. The number of emitters mounted on each of the outer surfaces is determined by the light specified in each direction to meet the desired lighting distribution configuration in each direction. A method of configuring an emitter lighting array assembly includes selecting the desired lighting distribution configuration to achieve a desired lighting distribution.

Abstract: A lighting array assembly has a plurality of support members facing different directions and on which emitters are mounted. Each support member has an emitter circuit thereon in operative association with at least one emitter and has a lighting center point. The emitters on each support member are positioned together around the lighting center point. The number of emitters mounted on each of the outer surfaces is determined by the light specified in each direction to meet the desired lighting distribution configuration in each direction. A method of configuring an emitter lighting array assembly includes selecting the desired lighting distribution configuration to achieve a desired lighting distribution.

Abstract: A baffle assembly is provided for use with a lighting fixture having light emitting diodes or emitters as a source of light. The baffle assembly has baffles with an emitter aperture there between. The emitters are mounted in the emitter apertures and the baffles control the light from the emitter into the desired lighting configuration. In one design, a portion of the light is radiated into a first zone that is closest to the fixture, another portion of the light is radiated into a second zone which is at least in part outwardly away from the first zone, and yet another portion of light is radiated with substantially no reflection by the baffles into a third zone, which is at least in part outwardly away from the second zone.