Patents by Inventor Michael R. Schrimpf

Michael R. Schrimpf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diazahomoadamantane derivatives and methods of use thereof
    Patent number: 8846661
    Abstract: The invention relates to compounds that are diazahomoadamantane derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: September 30, 2014
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Kevin B. Sippy
  • Substituted octahydrocyclopenta[c]pyrroles as calcium channel modulators
    Patent number: 8796470
    Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein ?, R1, R2, R3, and R4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: August 5, 2014
    Assignee: AbbVie Inc.
    Inventors: Xenia B. Searle, Ming C. Yeung, Michael R. Schrimpf
  • AZA-bridged ring-fused indoles and indolines
    Patent number: 8778959
    Abstract: The present application relates to indole and indoline derivatives of formula (I) wherein a, R1, R2, R3, h, i, j, m, n, L, Q, and X are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: July 15, 2014
    Assignee: AbbVie Inc.
    Inventors: Lei Shi, William H. Bunnelle, Tao Li, Marc J. Scanio, Michael R. Schrimpf, Chih-Hung Lee
  • AGENTS FOR TREATING PAIN AND USES THEREOF
    Publication number: 20140171423
    Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 19, 2014
    Applicant: ABBVIE INC.
    Inventors: Pramila A. Bhatia, John T. Randolph, Michael R. Schrimpf, Quinwei I. Zhang
  • Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers
    Patent number: 8669255
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: March 11, 2014
    Assignee: AbbVie Inc.
    Inventors: Tao Li, Sachin V. Patel, Richard J. Perner, John T. Randolph, Michael R. Schrimpf, Kevin R. Woller, Zhiren Xia, Qingwei Zhang
  • Substituted octahydropyrrolo[1,2-]pyrazine sulfonamides as calcium channel blockers
    Patent number: 8648074
    Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z?, Z?, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: February 11, 2014
    Assignee: AbbVie Inc.
    Inventors: Tao Li, Sachin V. Patel, Richard J. Perner, John T. Randolph, Michael R. Schrimpf, Kevin R. Woller, Zhiren Xia, Qingwei Zhang
  • Amino-aza-adamantane derivatives and methods of use
    Patent number: 8586746
    Abstract: The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evaluating the binding affinity to ?7 nicotinic acetylcholine receptors also are described.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 19, 2013
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Kevin B. Sippy, David J. Anderson, William H. Bunnelle, Diana L. Nersesian
  • Amide derivatives as positive allosteric modulators and methods of use thereof
    Patent number: 8536221
    Abstract: The invention relates to novel amide derivatives that are PAMs of neuronal nicotinic receptors, compositions comprising the same, processes for preparing such compounds, and methods for using such compounds and compositions.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: September 17, 2013
    Assignee: AbbVie Inc.
    Inventors: Kathleen H. Mortell, Diana L. Nersesian, Michael R. Schrimpf, Chih-Hung Lee, Murali Gopalakrishnan
  • Bridgehead amine ring-fused indoles and indolines
    Patent number: 8524703
    Abstract: The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R2, R3, h, k, m, n, L, Q, X, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 3, 2013
    Assignee: AbbVie Inc.
    Inventors: Lei Shi, William H. Bunnelle, Tao Li, Marc J. Scanio, Michael R. Schrimpf, Chih-Hung Lee
  • Azaadamantane derivatives and methods of use
    Patent number: 8314119
    Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: November 20, 2012
    Assignee: AbbVie Inc.
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Marc Scanio, Lei Shi, Chih-Hung Lee, William H. Bunnelle, Geoff G. Z. Zhang, Paul J. Brackemeyer, Shuang Chen, Rodger F. Henry
  • 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
    Patent number: 8268853
    Abstract: Compounds of formula (I) are useful in treating conditions or disorders ameliorated by ?4?2 positive allosteric modulators. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: September 18, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Chih-Hung Lee, Ramin Faghih, Gregory A. Gfesser
  • DIAZABICYCLIC CENTRAL NERVOUS SYSTEM ACTIVE AGENTS
    Publication number: 20120208820
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Application
    Filed: January 31, 2012
    Publication date: August 16, 2012
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • AZAADAMANTANE ESTER AND CARBAMATE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20120190704
    Abstract: The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: March 23, 2012
    Publication date: July 26, 2012
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Lei Shi
  • ACETAMIDE AND CARBOXAMIDE DERIVATIVES OF AZAADAMANTANE AND METHODS OF USE THEREOF
    Publication number: 20120190706
    Abstract: The invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: March 23, 2012
    Publication date: July 26, 2012
    Inventors: Marc J.C. Scanio, Lei Shi, William H. Bunnelle, Michael R. Schrimpf
  • Azaadamantane ester and carbamate derivatives and methods of use thereof
    Patent number: 8163916
    Abstract: The invention relates to compounds that are substituted azaadamantane ester and carbamate derivatives, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: April 24, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Diana L. Nersesian, Kevin B. Sippy, Jianguo Ji, Tao Li, Lei Shi
  • Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof
    Patent number: 8163914
    Abstract: The invention relates to compounds that are acetamide and carboxamide derivatives of azaadamantane, compositions comprising such compounds, and methods of using such compounds and compositions.
    Type: Grant
    Filed: March 20, 2008
    Date of Patent: April 24, 2012
    Assignee: Abbott Laboratories
    Inventors: Marc J. C. Scanio, Lei Shi, William H. Bunnelle, Michael R. Schrimpf
  • SPIROCYCLIC AZAADAMANTANE DERIVATIVES AND METHODS OF USE
    Publication number: 20120065219
    Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Application
    Filed: November 15, 2011
    Publication date: March 15, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Jianguo Ji, Michael R. Schrimpf, Kevin B. Sippy, Tao Li, Chih-Hung Lee
  • Diazabicyclic central nervous system active agents
    Patent number: 8119635
    Abstract: Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: February 21, 2012
    Assignee: Abbott Laboratories
    Inventors: Michael R. Schrimpf, Karin R. Tietje, Richard B. Toupence, Jianguo Ji, Anwer Basha, William H. Bunnelle, Jerome F. Daanen, Jennifer M. Frost, Kevin B. Sippy
  • Spirocyclic azaadamantane derivatives and methods of use
    Patent number: 8076350
    Abstract: The invention relates to compounds that are spirocyclic azaadamantane derivatives derivatives, particularly spirocyclic azaadamantanyl ether or amine derivatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: December 13, 2011
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, Michael R. Schrimpf, Kevin B. Sippy, Tao Li, Chih-Hung Lee
  • SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS
    Publication number: 20110294854
    Abstract: The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein a, R1, R2, R3, and R4 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
    Type: Application
    Filed: May 24, 2011
    Publication date: December 1, 2011
    Applicant: ABBOTT LABORATORIES
    Inventors: Xenia B. Searle, Ming C. Yeung, Michael R. Schrimpf