Abstract: Provided herein are methods and corresponding compounds for treating fibrotic disease by administering to a subject a compound of Formula I or pharmaceutically acceptable salt thereof, which inhibits phosphorylation of Smad2/3, according to Phospho-Smad2/3 Inhibition Assay, including compounds that are active according to MAPK p38 Activation Assay; or a compound of Formula II or III. Also provided are methods and corresponding compounds for treating cancers, inflammatory diseases, rasopathies and autoimmune leukoproliferative disorders.

Abstract: Cartilage fibers and implants made therefrom are disclosed, with and without cartilage particles. Methods for making the cartilage fibers and the implants containing them are also disclosed. The implants may be pre-shaped, may be reshapable and, when implanted in a cartilage defect, the implants have good shape retention, little swelling, completely fill the cartilage defect and resist migration from the defect upon irrigation.

Abstract: A tension sensor includes a planar tab having a first and second side, first and second end sections and an aperture through each of the end sections. A first strain gage is attached to the first side of the tab. The first strain gage has a tension grid aligned to a longitudinal axis of the tab and a cross-tension grid perpendicular to the tension grid. A second strain gage is attached to the second side of the tab. The second strain gage has a tension grid aligned to the longitudinal axis of the tab and a cross-tension grid perpendicular to the tension grid. The first strain gage and second strain gage are wired in a Wheatstone bridge in which the tension grid and the cross-tension grid of the first strain gage form one side and the tension grid and the cross-tension grid of the second strain gage form another side.

Abstract: A covered hopper railcar includes a roof portion and a plurality of side portions coupled to the roof portion. The plurality of side portions and the roof portion at least partially define a longitudinal centerline axis and a transverse centerline axis that is substantially perpendicular to the longitudinal centerline axis. The covered hopper railcar also includes a bottom assembly coupled to the side portions. The bottom assembly includes a plurality of bottom side sheets and a trough assembly coupled to the plurality of bottom side sheets. The trough assembly is substantially parallel to and substantially aligned with the longitudinal centerline axis.

Abstract: A covered hopper railcar includes a roof portion and a plurality of side portions coupled to the roof portion. The plurality of side portions and the roof portion at least partially define a longitudinal centerline axis and a transverse centerline axis that is substantially perpendicular to the longitudinal centerline axis. The covered hopper railcar also includes a bottom assembly coupled to the side portions. The bottom assembly includes a plurality of bottom side sheets and a trough assembly coupled to the plurality of bottom side sheets. The trough assembly is substantially parallel to and substantially aligned with the longitudinal centerline axis.

Abstract: A strength member sewing machine is provided which comprises upper and lower feeder spools, a collection spool and idlers positioned on a support structure. A cord supply, a fabric shaper, a speed control and a pressure foot lift are positioned on the structure. Fabric from the spools is kept in tension with the idlers while moving toward the fabric shaper. The fabric from the upper spool is crimped while the fabric from the lower spool remains flat underneath the shaper. Between the fabric layers, pull cords are pulled through from the cord supply thru the fabric shaper. The fabric with crimps and with the pull cords inside the crimps is sewn to the fabric from the lower spool to create casings with a pull cord in the internal space of each casing. The joined fabrics with the pull cords are collected by the collection spool as a finished product.

Abstract: Populating a well log. At least some of the illustrative embodiments are methods including: performing a well logging operation at a physical location of a wellbore, the performing by: positioning a logging system proximate to the physical location of the wellbore; determining, by a computer system associated with the logging system, a physical location of the logging system; reading, by the computer system, from a third party source, information related to the physical location of the logging system; populating, by the computer system, a header section of a well log report, the populating based on information from the third party source; and performing the well logging operation.

Abstract: A covered hopper railcar includes a roof portion and a plurality of side portions coupled to the roof portion. The plurality of side portions and the roof portion at least partially define a longitudinal centerline axis and a transverse centerline axis that is substantially perpendicular to the longitudinal centerline axis. The covered hopper railcar also includes a bottom assembly coupled to the side portions. The bottom assembly includes a plurality of bottom side sheets and a trough assembly coupled to the plurality of bottom side sheets. The trough assembly is substantially parallel to and substantially aligned with the longitudinal centerline axis.

Abstract: A system and method for managing a herd of animals possibly requiring medical treatment, such as cows in a feedlot. The animals are herded individually into a chute, where identification data is collected from a tag, and core temperature data is collected using a special non-contacting core temperature sensor. The animal is tagged with a color coded tag representing a range of temperatures into which that animal's temperature falls. The animal is then delivered to a pen corresponding to that range of temperatures, where appropriate medicinal treatment is automatically dosed and applied to the animal.

Abstract: A covered hopper railcar includes a roof portion and a plurality of side portions coupled to the roof portion. The plurality of side portions and the roof portion at least partially define a longitudinal centerline axis and a transverse centerline axis that is substantially perpendicular to the longitudinal centerline axis. The covered hopper railcar also includes a bottom assembly coupled to the side portions. The bottom assembly includes a plurality of bottom side sheets and a trough assembly coupled to the plurality of bottom side sheets. The trough assembly is substantially parallel to and substantially aligned with the longitudinal centerline axis.

Abstract: Generally, the present disclosure is directed to systems that may be used to facilitate the retrieval and/or replacement of production and/or processing equipment that may be used for subsea oil and gas operations. In one illustrative embodiment, a method is disclosed that includes, among other things, removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment (100) while the subsea equipment (100) is connected to a subsea equipment installation (185) in a subsea environment (180), and storing at least the removed portion of the trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 132) that is positioned in the subsea environment (180). Additionally, the disclosed method also includes disconnecting the subsea equipment (100) from the subsea equipment installation (185) and retrieving the subsea equipment (100) from the subsea environment (180).

Abstract: Generally, the present disclosure is directed to systems that may be used to facilitate the retrieval and/or replacement of production and/or processing equipment that may be used for subsea oil and gas operations. In one illustrative embodiment, a method is disclosed that includes, among other things, removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment (100) while the subsea equipment (100) is connected to a subsea equipment installation (185) in a subsea environment (180), and storing at least the removed portion of the trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 132) that is positioned in the subsea environment (180). Additionally, the disclosed method also includes disconnecting the subsea equipment (100) from the subsea equipment installation (185) and retrieving the subsea equipment (100) from the subsea environment (180).

Abstract: Generally, the present disclosure is directed to systems that may be used to facilitate the retrieval and/or replacement of production and/or processing equipment that may be used for subsea oil and gas operations. In one illustrative embodiment, a method is disclosed that includes, among other things, removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment (100) while the subsea equipment (100) is connected to a subsea equipment installation (185) in a subsea environment (180), and storing at least the removed portion of the trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 132) that is positioned in the subsea environment (180). Additionally, the disclosed method also includes disconnecting the subsea equipment (100) from the subsea equipment installation (185) and retrieving the subsea equipment (100) from the subsea environment (180).

Abstract: Populating a well log. At least some of the illustrative embodiments are methods including: performing a well logging operation at a physical location of a wellbore, the performing by: positioning a logging system proximate to the physical location of the wellbore; determining, by a computer system associated with the logging system, a physical location of the logging system; reading, by the computer system, from a third party source, information related to the physical location of the logging system; populating, by the computer system, a header section of a well log report, the populating based on information from the third party source; and performing the well logging operation.

Abstract: Generally, the present disclosure is directed to systems that may be used to facilitate the retrieval and/or replacement of production and/or processing equipment that may be used for subsea oil and gas operations. In one illustrative embodiment, a method is disclosed that includes, among other things, removing at least a portion of trapped production fluid (101a, 101b) from subsea equipment (100) while the subsea equipment (100) is connected to a subsea equipment installation (185) in a subsea environment (180), and storing at least the removed portion of the trapped production fluid (101a, 101b) in a subsea containment structure (120, 120a, 120b, 132) that is positioned in the subsea environment (180). Additionally, the disclosed method also includes disconnecting the subsea equipment (100) from the subsea equipment installation (185) and retrieving the subsea equipment (100) from the subsea environment (180).

Abstract: A covered hopper railcar includes a roof portion and a plurality of side portions coupled to the roof portion. The plurality of side portions and the roof portion at least partially define a longitudinal centerline axis and a transverse centerline axis that is substantially perpendicular to the longitudinal centerline axis. The covered hopper railcar also includes a bottom assembly coupled to the side portions. The bottom assembly includes a plurality of bottom side sheets and a trough assembly coupled to the plurality of bottom side sheets. The trough assembly is substantially parallel to and substantially aligned with the longitudinal centerline axis.

Abstract: A solder paste transfer process is provided and includes defining multiple arrangements of solder pad locations on a surface, applying solder paste onto multiple transfer tools coupled to a fixture in a pre-defined configuration reflective of the multiple arrangements, disposing the fixture such that the multiple transfer tools are disposed in an inverted orientation proximate to the surface and reflowing the solder paste to flow from the multiple transfer tools to the solder pad locations.

Abstract: A solder paste transfer process is provided and includes defining multiple arrangements of solder pad locations on a surface, applying solder paste onto multiple transfer tools coupled to a fixture in a pre-defined configuration reflective of the multiple arrangements, disposing the fixture such that the multiple transfer tools are disposed in an inverted orientation proximate to the surface and reflowing the solder paste to flow from the multiple transfer tools to the solder pad locations.

Abstract: A system and method for managing a herd of animals possibly requiring medical treatment, such as cows in a feedlot. The animals are herded individually into a chute, where identification data is collected from a tag, and core temperature data is collected using a special non-contacting core temperature sensor. The animal is tagged with a color coded tag representing a range of temperatures into which that animal's temperature falls. The animal is then delivered to a pen corresponding to that range of temperatures, where appropriate medicinal treatment is automatically dosed and applied to the animal.