Patents by Inventor Michael R. Zile

Michael R. Zile has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PLASMA ANALYTES PREDICT DIAGNOSIS AND PROGNOSIS OF THORACIC AORTIC ANEURYSM
    Publication number: 20150203916
    Abstract: Disclosed are methods and materials for assessing thoracic aortic aneurysm using a combination of protein and microRNA biomarkers. The presence or levels of the biomarkers can be measured in a body fluid, such as plasma and serum, or in cardiac tissue, to predict the presence and severity of TAA in a subject. This can be used to diagnose and monitor TAA, providing early detection of a lethal and silent disease, as well as reduce the frequency of radiological procedures, which are costly and potentially dangerous.
    Type: Application
    Filed: June 27, 2013
    Publication date: July 23, 2015
    Inventors: John S. Ikonomidis, Jeffrey A. Jones, Mukherjee Rupak, Robert E. Stroud, Michael R. Zile
  • Detecting diastolic heart failure by protease and protease inhibitor plasma profiling
    Patent number: 8790871
    Abstract: Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: July 29, 2014
    Assignee: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile
  • Assessing left ventricular remodeling via temporal detection and measurement of microRNA in body fluids
    Patent number: 8592151
    Abstract: Disclosed are methods and materials for assessing cardiac failure, cardiac hypertrophy, and left ventricular remodeling using microRNA levels. The level of microRNAs can be measured in a body fluid, such as plasma and serum.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: November 26, 2013
    Assignee: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Michael R. Zile, Robert E. Stroud
  • Assessing Cardiac Disease Via Detection and Measurement of MicroRNA
    Publication number: 20130289141
    Abstract: Disclosed are methods and materials for assessing cardiac disease, including cardiac failure, cardiac hypertrophy, thoracic aortic aneurysm, left ventricular remodeling using microRNA levels. The level of microRNAs can be measured in a body fluid, such as plasma and serum, or in cardiac tissue.
    Type: Application
    Filed: November 11, 2011
    Publication date: October 31, 2013
    Applicant: Medical University of South Carolina
    Inventors: Francis G. Spinale, Michael R. Zile, Robert E. Stoud, John S. Ikonomidis, Jeffrey A. Jones
  • Predicting heart failure following myocardial infarction by protease and protease inhibitor profiling
    Patent number: 8445222
    Abstract: Disclosed herein are methods of detecting or predicting diastolic heart failure in a subject, comprising identifying a profile of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) from a body fluid of the subject that is associated herein with the existence of likely development of left ventricular dilation (LVD).
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: May 21, 2013
    Assignee: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile
  • DETECTING AND MONITORING LEFT VENTRICULAR HYPERTROPHY AND CONGESTIVE HEART FAILURE BY PROFILING BIOMARKERS
    Publication number: 20120010094
    Abstract: Disclosed herein are methods of detecting, monitoring, and predicting left ventricular hypertrophy, congestive heart failure and related conditions by profiling biomarkers.
    Type: Application
    Filed: November 4, 2009
    Publication date: January 12, 2012
    Applicant: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Michael R. Zile, Robert E. Stroud
  • ASSESSING LEFT VENTRICULAR REMODELING VIA TEMPORAL DETECTION AND MEASUREMENT OF microRNA IN BODY FLUIDS
    Publication number: 20110117560
    Abstract: Disclosed are methods and materials for assessing cardiac failure, cardiac hypertrophy, and left ventricular remodeling using microRNA levels. The level of microRNAs can be measured in a body fluid, such as plasma and serum.
    Type: Application
    Filed: November 11, 2010
    Publication date: May 19, 2011
    Applicant: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Michael R. Zile, Robert E. Stroud
  • Predicting Heart Failure Following Myocardial Infarction by Protease and Protease Inhibitor Profiling
    Publication number: 20100015651
    Abstract: Disclosed herein are methods of detecting or predicting diastolic heart failure in a subject, comprising identifying a profile of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) from a body fluid of the subject that is associated herein with the existence of likely development of left ventricular dilation (LVD).
    Type: Application
    Filed: July 11, 2007
    Publication date: January 21, 2010
    Applicant: MUSC Foundation for Research Development
    Inventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile
  • Detecting Diastolic Heart Failure by Protease and Protease Inhibitor Plasma Profiling
    Publication number: 20090221015
    Abstract: Disclosed herein are methods of detecting and predicting diastolic heart failure and predicting congestive heart failure comprise protease and protease inhibitor profiling.
    Type: Application
    Filed: April 24, 2007
    Publication date: September 3, 2009
    Inventors: Francis G. Spinale, Robert E. Stroud, Michael R. Zile